Integrin alpha-M Antibodies

Integrin alpha-M (ITGAM)

It's identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b.

Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Gene Information

Human
Gene Name:	ITGAM
Uniprot:	P11215
Entrez:	3684

Family

Belongs to:
integrin alpha chain family

Alternative Names

antigen CD11b (p170); CD11 antigen-like family member B; CD11b antigen; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; Complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; CR3AMGC117044; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; MAC 1; MAC1; MAC-1; Mac1, alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha polypeptide; Mo1, alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; Neutrophil adherence receptor; SLEB6

Molecular Weight

Mass (kDA):
127.179 kDA

Genomic Context

Human
Location:	16p11.2
Sequence:	16; NC_000016.10 (31259975..31332877)

Tissue Specificity

Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.

Diseases

• Tissue Adhesions
• Inflammation
• Lupus Erythematosus, Systemic
• Leukemia
• Neoplasms
• Malignant Neoplasms
• Atherosclerosis
• Inflammatory Response
• Autoimmune Reaction
• Autoimmune Diseases
• Arthritis
• Acute Promyelocytic Leukemia
• Leukemia, Myelocytic, Acute

• Myeloid Leukemia
• Pain
• Gliosis
• Infective Disorder
• Melanoma
• Hyperalgesia
• Obesity

Pathways

• Pathogenesis
• Inflammatory Response
• Cell Adhesion
• Neutrophil Activation
• Immune Response
• Chemotaxis
• Monocyte Activation
• Cell Differentiation
• Phagocytosis
• Secretion
• Cell Cycle
• Platelet Activation
• Leukocyte Activation

• Cell Proliferation
• Cell Activation
• Angiogenesis
• Cell Migration
• Hypersensitivity
• Respiratory Burst
• Neutrophil Chemotaxis

PTMs

• Phosphorylation
• Cleavage
• Reduction
• Oxidation

• Nitration
• Carboxylation
• Acetylation
• Dephosphorylation

• Myristoylation

Research Areas

• Breast Cancer
• Cancer
• Cell Biology
• Cellular Markers
• Glia Markers

• Hematopoietic Stem Cell Markers
• Immunology
• Innate Immunity
• Microglia Markers
• Myeloid Cell Markers

• Neuroscience
• Signal Transduction
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGAM

Best Uses Of The ITGAM Marker

Anti-ITGAM antibodies are available from a variety of suppliers. They are a well-documented marker for microglia. People with large samples should make use of multichannel pipettes. If you wish to share your results with colleagues You can request product credits from Boster Bio. Listed below are some of the most beneficial uses for this marker. Keep reading to learn more. This article will assist you in understanding the best uses of the ITGAM marker prior to you purchase antibodies.

Anti-ITGAM antibodies can be purchased from many suppliers

Anti-ITGAM antigens, monoclonal proteins that react with the human Integrin subunit M are monoclonal proteins. This protein weighs approximately 127.2 Kilodaltons. This protein is a common marker for microglia. Many vendors offer anti-ITGAM antigens. Suppliers can also provide comprehensive information on the product.

These antibodies can be used for a variety of purposes. They can be utilized in immunohistochemistry for the identification of endothelial cells in KD cells, or in the control of KD cells. They can also be used to detect specific proteins using the qPCR. To identify specific proteins, we used primers against Il6, Gapdh, and Il10.

They are a well-documented identifier for microglia

Numerous studies have documented the presence of ITGAM markers in human brains. These molecules are also referred to by many other names, like CD68, CD14 and IBA-1. These molecules are employed as the primary markers used in the study of brain microglia. There isn't consensus on their function. A variety of factors can contribute to their expression. These factors are described below.

IBA1 is a protein that can be found in brains , however it is only expressed in microglia. It is also a marker for microglia and shows a decline after activation. Zrzavy T et al. identified resting and homeostatic microglia within the white matter and cortices and Cserep showed that P2RY12 is vital in the development of somatic microglia-neuron junctions.

We utilized a bioinformatics-based technique to discover new translational microglia markers for ITGAM markers in human brain tissue. We tested these markers in vitro and ex vivo, using mouse and human brain samples. A PET tracer which targets microglia was created, which gives quantitative measures of activation. These findings will be used in the development of non-invasive microglia markers that can be used in preclinical as well as clinical studies.

The ITGAM markers are used as a microglia-specific document. They are found in many morphologies including amoeboid microglia rounded, as well as macrophages with foamy morphology. However, there is a debate as to whether they are a reliable microglia marker. In the meantime, the evidence suggests that ITGAM markers can be a useful tool in studying the function of microglia in brain.

CD45 is an inhibitor of protein tyrosinephosphatase also known as PTP. This PTP receptor regulates a number of biological processes. CD45 is found in all human hematopoietic cells. It is among the most well-known microglia markers. In addition it has been proven to increase the number of AD-associated microglia. It has been utilized in the study on human microglia.

The study revealed that the levels of ITGAM mRNA expression were 35-fold greater in microglia than in other brain cells. After rIL4 injection the expression of Calcrl increased 1.51-fold in microglia. Although microglia are an important target for a variety of neurological and mental illnesses, there isn't conclusive evidence that they play a part in.

They can be combined with DyLight(r) 488

Boster Bio Anti-human CD11b Itgam monoclonal antibody is flow tested and reacts with Human. It is obtainable at 4degC and can be stored for a year. In conjunction with ITGAM, blocking peptides are offered separately. There are many companies that offer antibodies against ITGAM protein. The antibody recognizes integrin M, also referred to by macrophage-1 antigen or cluster of differentiation molecule 11.B. It is a subunit of a protein that is involved in blood vessel repair after mechanical arterial injury. The protein recognizes the R-G-D peptide in C3b and acts as a receptor for fibrinogen, factor X and ICAM1.

They are available from Boster Bio

If you're looking for high-quality antibodies, ELISA kits, and buffers, you can count on Boster Bio. Boster Bio's product range includes more than 16,000 different antibodies that are approved for use in WB and FC. Boster provides free secondary antibodies and rabbit polyclonal antibody when you purchase an antibody that is the primary one. Boster also produces its own ELISA kits and antibodies to ensure the highest quality. Boster Bio offers high-quality lysis buffers that guarantee the most efficient results. Apart from providing high-quality antibodies Boster Bio also provides high-quality buffers that ensure that your experiments will be successful and reduce cross-linking intensities.

Steven Xia (an immunologist) was the founder of Boster Bio in 1993. Boster Bio manufactures high-sensitivity and targeted antibodies. Their products for antibodies have been thoroughly tested and referenced in more than 29,000 scientific publications. Additionally, they have been optimized for ELISA and WB applications. The Boster Quality Guarantee guarantees that each antibody will perform according to the specifications. Boster Bio products have been trusted by researchers and scientists around the world.

The company also offers ELISA kits to detect multiple kinds of proteins, cytokines, and antigens. Boster has over 20 years of expertise and the trust of more than 10,000 scientists. Picokine ELISA kit allows scientists to speed up scientific discovery by allowing them to perform up to 96 tests. They can also be tested for various samples. Boster offers immunological reagents with tebu bio in addition to the Picokine ELISA kit.