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- Table of Contents
Integrin alpha-M Antibodies
AND ITGAM ELISA kits, Integrin alpha-M Proteins
Many biological assays use antibodies to detect Integrin alpha-M, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-M in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-M antibodies...
Designing a Western blot for Integrin alpha-M? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGAM Western Blot GuideITGAM Infographic by Boster Bio
All ITGAM Products
Product
Figures
Specificity
Applications
Price
Anti-CD11b ITGAM Rabbit Monoclonal Antibody
33 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00144-1
100 μl
Cat # M00144-1
100 μl
Anti-CD11b/ITGAM Antibody Picoband®
6 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9140
100 μg/vial
Cat # PB9140
100 μg/vial
Anti-P21/CDKN1A Antibody Picoband®
5 Citations
Human
ELISA, IF, IHC, ICC, WB
$370
Cat # A00145-1
100 µg/vial
Cat # A00145-1
100 µg/vial
Anti-CD11b/ITGAM Antibody Picoband®
1 Citations
Human, Mouse
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00144-1
100 μg/vial
Cat # A00144-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00144-5
20μL, 40μL, 100μL, 200μL
Cat # M00144-5
20μL, 40μL, 100μL, 200μL
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00144
100 μl
Cat # M00144
100 μl
Human
IHC, WB
$449
Cat # M00144-2
100uL
Cat # M00144-2
100uL
ITGAM Overview
Facts about Integrin alpha-M.
Integrin alpha-M (ITGAM)
It's identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b.
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGAM |
| Uniprot: | P11215 |
| Entrez: | 3684 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
antigen CD11b (p170); CD11 antigen-like family member B; CD11b antigen; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; Complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; CR3AMGC117044; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; MAC 1; MAC1; MAC-1; Mac1, alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha polypeptide; Mo1, alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; Neutrophil adherence receptor; SLEB6
Molecular Weight
Mass (kDA):
127.179 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (31259975..31332877) |
Tissue Specificity
Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Inflammation
- Lupus Erythematosus, Systemic
- Leukemia
- Neoplasms
- Malignant Neoplasms
- Atherosclerosis
- Inflammatory Response
- Autoimmune Reaction
- Autoimmune Diseases
- Arthritis
- Acute Promyelocytic Leukemia
- Leukemia, Myelocytic, Acute
Pathways
- Pathogenesis
- Inflammatory Response
- Cell Adhesion
- Neutrophil Activation
- Immune Response
- Chemotaxis
- Monocyte Activation
- Cell Differentiation
- Phagocytosis
- Secretion
- Cell Cycle
- Platelet Activation
- Leukocyte Activation
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Oxidation
Research Areas
- Breast Cancer
- Cancer
- Cell Biology
- Cellular Markers
- Glia Markers
- Hematopoietic Stem Cell Markers
- Immunology
- Innate Immunity
- Microglia Markers
- Myeloid Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGAM
bosterbio.com/bosterbio-gene-info-cards/ITGAM
References
PMID: 2457584 by Corbi A.L., et al. The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
PMID: 2833753 by Arnaout M.A., et al. Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.
11 Publications of Boster Integrin alpha-M Antibodies & ELISA Kits
- PubMed ID: PMID:25691929, Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial...
- PubMed ID: 10.1159/000358235, The Neurovascular Protective Effects of Huperzine A on D-Galactose-Induced Infla...
- PubMed ID: 10.1016/j.cellbi.2009.01.008, Rat bone marrow derived mesenchymal progenitor cells support mouse ES cell growt...
- PubMed ID: 10.1007/s12192-010-0203-0, Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes ather...
- PubMed ID: 28100749, Promoted interaction of C/EBP%u03B1 with demethylated Cxcr3 gene promoter contri...
- PubMed ID: 20607472, Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes ather...
- PubMed ID: 20582224, Cloning, characterization, and expression analysis of goat (Capra hircus) phosph...
- PubMed ID: 25491263, Ren B, Zhang Yx, Zhou Hx, Sun Fw, Zhang Zf, Wei Z, Zhang Cy, Si Dw. J Neurol Sci...
- PubMed ID: 23158928, Zhao G, Wang S, Wang Z, Sun A, Yang X, Qiu Z, Wu C, Zhang W, Li H, Zhang Y, Zhao...
- PubMed ID: 25691929, Mu L, Jing C, Guo Z. Iran J Basic Med Sci. 2014 Nov;17(11):874-8. Expressions Of...
- PubMed ID: 22142175, Yuan Y, Su Z, Pu Y, Liu X, Chen J, Zhu F, Zhu Y, Zhang H, He C. Br J Pharmacol. ...
*More publications can be found for each product on its corresponding product page