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Ligand for IL17RA and IL17RC (PubMed:17911633).The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971).
Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732).
|Sequence:||6; NC_000006.12 (52236681..52245689, complement)|
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
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