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- Table of Contents
LCK Antibodies
AND LCK ELISA kits, LCK Proteins
Many biological assays use antibodies to detect LCK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LCK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LCK antibodies...
Designing a Western blot for LCK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LCK Western Blot GuideLCK Infographic by Boster Bio
All LCK Products
Product
Figures
Specificity
Applications
Price
Anti-SQSTM1/p62 Antibody Picoband®
37 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9444
100 μg/vial
Cat # PB9444
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00300-1
100 μg/vial
Cat # M00300-1
100 μg/vial
Anti-p62/SQSTM1 Rabbit Monoclonal Antibody
12 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00300
100 μl
Cat # M00300
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00327-2
100 μg/vial
Cat # M00327-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1955
100 μg/vial
Cat # PA1955
100 μg/vial
Anti-SQSTM1 / p62 Rabbit Monoclonal Antibody
4 Citations
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00300-3
100 μl/vial
Cat # M00300-3
100 μl/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9808
100 μg/vial
Cat # PB9808
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00425-1
20μL, 40μL, 100μL, 200μL
Cat # M00425-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2450
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2450
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2085
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2085
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2084
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2084
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1338
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1338
1 kit, containing one 96-well plate and all necessary reagents
LCK Overview
Facts about Tyrosine-protein kinase Lck.
Tyrosine-protein kinase Lck (LCK)
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the role of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways.
Constitutively linked to the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the related LCK protein to the area of the TCR/CD3 complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | LCK |
| Uniprot: | P06239 |
| Entrez: | 3932 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.2; Hck-3; Lck; Lcktkr; Leukocyte C-terminal Src kinase; LSK; LSTRA; Lymphocyte cell-specific protein-tyrosine kinase; lymphocyte-specific protein tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; p56lck; p56-LCK; pp58lck; Protein YT16; Proto-oncogene Lck; proto-oncogene tyrosine-protein kinase LCK; T cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; tyrosine-protein kinase Lck; YT16
Molecular Weight
Mass (kDA):
58.001 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.2 |
| Sequence: | 1; NC_000001.11 (32251265..32286167) |
Tissue Specificity
Expressed specifically in lymphoid cells.
Subcellular Localizations
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Present in lipid rafts in an inactive form.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Lymphoma
- Tissue Adhesions
- Hiv Infections
- Immunologic Deficiency Syndromes
- Autoimmune Reaction
- Leukemia, T-cell
- Cell Transformation, Neoplastic
- Carcinoma
- Inflammation
- Chimera Disorder
Interacting Proteins
- ADAM15
- AR
- BCL3
- CD4
- CDKAL1
- FLT3
- GAB1
- GATA3
- HSP90AB1
- KHDRBS1
Pathways
- Cell Activation
- T Cell Activation
- Localization
- Cell Development
- Cell Proliferation
- Immune Response
- T Cell Proliferation
- Cell Death
- Pathogenesis
- Secretion
- Cell Growth
- Lymphocyte Activation
- Cytokine Production
PTMs
- Phosphorylation
- Dephosphorylation
- Palmitoylation
- Myristoylation
- Cleavage
- Acylation
- Ubiquitination
- Methylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LCK
bosterbio.com/bosterbio-gene-info-cards/LCK
References
PMID: 3493153 by Koga Y., et al. A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
PMID: 3265417 by Perlmutter R.M., et al. Structure and expression of lck transcripts in human lymphoid cells.
18 Publications of Boster LCK Antibodies & ELISA Kits
- PubMed ID: PMID:27293989, Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.3390/ijms19123948, Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gen...
- PubMed ID: 10.1093/jnen/nlaa007, Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/se...
- PubMed ID: 10.1089/ars.2017.7044, Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Iso...
- PubMed ID: -, Zhiwei Liao,Suyun Li,Rong Liu,Xiaobo Feng,Yunsong Shi,Kun Wang,Shuai Li,Yukun Zh...
- PubMed ID: -, Zhang Tao,Xiaoqing Zhou,Yan Zhang,Wenfeng Pu,Yi Yang,Fuxia Wei,Qian Zhou,Lin Zha...
- PubMed ID: -, Liu, J.,Qin, X.,Ma, W.,Jia, S.,Zhang, X.,Yang, X. ... Jin, F. (2021). Corilagin ...
- PubMed ID: 32098126, Zhong W,Tang X,Liu Y,Zhou C,Liu P,Li E,Zhong P,Lv H,Zou Q,Wang M.Benzoxazole Der...
- PubMed ID: 32425551, Liu X,Feng C,Wei G,Kong W,Meng H,Du Y,Li J.Mitofusin1 Is a Major Mediator in Glu...
- PubMed ID: 32015954, Yuan H,Wang Y,Chen H,Cai X.Protective effect of flavonoids from Rosa roxburghii ...
- PubMed ID: 31900522, Song L,Yao L,Zhang L,Piao Z,Lu Y.Schizandrol A protects against Aβ1-42-induced ...
- PubMed ID: 29085598, Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduce...
- PubMed ID: 28266555, Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia...
- PubMed ID: 27383629, Nrf2 signalling andautophagyare involved in diabetes mellitus-induced defects in...
- PubMed ID: 26228022, Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock?19/+ ...
- PubMed ID: 26120766, Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitocho...
- PubMed ID: 29052054, Song J, Hu Y, Li J, Zheng H, Wang J, Guo L, Shi H, Liu L. Arch Virol. 2018 Jan;1...
*More publications can be found for each product on its corresponding product page