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- Table of Contents
MMP12 Antibodies
AND MMP12 ELISA kits, MMP12 Proteins
Many biological assays use antibodies to detect MMP12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMP12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMP12 antibodies...
Designing a Western blot for MMP12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MMP12 Western Blot GuideMMP12 Infographic by Boster Bio
All MMP12 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA, WB
$370
Cat # RP1089
100 μg/vial
Cat # RP1089
100 μg/vial
MMP12 Overview
Facts about Macrophage metalloelastase.
Macrophage metalloelastase (MMP12)
May be involved in tissue injury and remodeling. Has significant elastolytic activity.
Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred in the P1 site, with small hydrophobic residues (preferably alanine) inhabiting P3.
Gene Information
| Human | |
|---|---|
| Gene Name: | MMP12 |
| Uniprot: | P39900 |
| Entrez: | 4321 |
Family
| Belongs to: |
|---|
| peptidase M10A family |
Alternative Names
EC 3.4.24; hME; HMEEC 3.4.24.65; Macrophage elastase; macrophage metalloelastase; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); Matrix metalloproteinase-12; ME; MGC138506; MME; MMP12; MMP-12
Molecular Weight
Mass (kDA):
54.002 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.2 |
| Sequence: | 11; NC_000011.10 (102862736..102874982, complement) |
Tissue Specificity
Found in alveolar macrophages but not in peripheral blood monocytes.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Inflammation
- Lung Diseases
- Malignant Neoplasms
- Neoplasms
- Pulmonary Emphysema
- Chronic Obstructive Airway Disease
- Lung Diseases, Obstructive
- Carcinoma
- Cell Invasion
- Neoplasm Metastasis
- Fibrosis
- Tumor Angiogenesis
- Atherosclerosis
Pathways
- Pathogenesis
- Angiogenesis
- Inflammatory Response
- Tissue Remodeling
- Proteolysis
- Localization
- Secretion
- Cell Migration
- Cell Proliferation
- Macrophage Activation
- Immune Response
- Wound Healing
- Cell Adhesion
PTMs
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP12
bosterbio.com/bosterbio-gene-info-cards/MMP12
References
PMID: 8226919 by Shapiro S.D., et al. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
PMID: 9115292 by Gronski T.J. Jr., et al. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase.
16 Publications of Boster MMP12 Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2017.7012, Elastin‑derived peptides are involved in the processes of human temporomandibu...
- PubMed ID: 10.1378/chest.14-2868, Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan...
- PubMed ID: 10.1155/2019/7142438, Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Brea...
- PubMed ID: 10.1152/ajplung.00214.2019, ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocy...
- PubMed ID: 10.1128/JVI.02534-15, Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the L...
- PubMed ID: 10.1111/jcmm.13057, Concomitant elevations of MMP‐9, NGAL, proMMP‐9/NGAL and neutrophil elastase...
- PubMed ID: 10.1007/s10238-021-00692-1, Impact of cathepsin D activity and C224T polymorphism (rs17571) on chronic obstr...
- PubMed ID: 10.1002/jgm.2999, MMP‐3 (–1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metallo...
- PubMed ID: 33611777, Bchir S,Boumiza S,Ben Nasr H,Garrouch A,Kallel I,Tabka Z,Chahed K.Impact of cath...
- PubMed ID: 33545548, Li J,Xie Y,Zhao P,Qin Y,Oliver BG,Tian Y,Li S,Wang M,Liu X. A chinese herbal for...
- PubMed ID: 28714016, Elastin-derived peptides are involved in the processes of human temporomandibula...
- PubMed ID: 28004483, Concomitant elevations of MMP?9, NGAL, proMMP?9/NGAL and neutrophil elastase in ...
- PubMed ID: 26676790, Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the L...
- PubMed ID: 26126526, Acute exacerbations of COPD are associated with significant activation of matrix...
- PubMed ID: 28393366, Narimiya T, Wada S, Kanzaki H, Ishikawa M, Tsuge A, Yamaguchi Y, Nakamura Y. J P...
- PubMed ID: 25489966, Vaz M, Rajasekaran S, Potteti Hr, Reddy Sp. Am J Respir Cell Mol Biol. 2015 Jul;...
*More publications can be found for each product on its corresponding product page