Protein kinase C beta type (PRKCB)

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a crucial role in B-cell activation by regulating BCR-induced NF-kappa-B activation.

Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at'Ser-559','Ser-644' and'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruiting of the BCL10-MALT1 complex in addition to MAP3K7/TAK1, which then activates IKK complex, leading to nuclear translocation and activation of NFKB1.