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- Table of Contents
SRY Antibodies
AND SRY ELISA kits, SRY Proteins
Many biological assays use antibodies to detect SRY, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRY in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRY antibodies...
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SRY Infographic by Boster Bio
All SRY Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1778
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1778
1 kit, containing one 96-well plate and all necessary reagents
SRY Overview
Facts about Sex-determining region Y protein.
Sex-determining region Y protein (SRY)
Transcriptional regulator which controls a genetic switch in male development. It's necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli as opposed to granulosa cells (By similarity).
In male mature brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation such as promoter activation or repression (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SRY |
| Uniprot: | Q05066 |
| Entrez: | 6736 |
Family
| Belongs to: |
|---|
| SRY family |
Alternative Names
essential protein for sex determination in human males; sex determining region Y; sex-determining region on Y; sex-determining region Y protein; TDFsex determining region protein; TDY; Testis-determining factor
Molecular Weight
Mass (kDA):
23.884 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Yp11.2 |
| Sequence: | Y; NC_000024.10 (2786855..2787682, complement) |
Subcellular Localizations
Nucleus speckle. Cytoplasm. Nucleus. Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880). Colocalizes with SOX6 in speckles (PubMed:11818535). Colocalizes with CAML in the nucleus (PubMed:15746192). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity).
Diseases
- Disorders Of Sex Development
- Congenital Abnormality
- Gonadal Dysgenesis
- Embryonic Mosaic
- Sex Chromosome Aberrations
- Xx Male
- Neoplasms
- Xy Female
- Infertility
- Turner Syndrome
- True Hermaphroditism (disorder)
- Hermaphroditism
- Ambiguous Genitalia
Pathways
- Sex Determination
- Sex Differentiation
- Spermatogenesis
- Male Sex Determination
- Cell Differentiation
- Localization
- Meiosis
- Gonad Development
- Sertoli Cell Differentiation
- Cell Migration
- Fertilization
- Cell Proliferation
- Metaphase
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Acetylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRY
bosterbio.com/bosterbio-gene-info-cards/SRY
References
PMID: 1695712 by Sinclair A.H., et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.
PMID: 8434602 by Su H., et al. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach.