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The formation of this receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 that dissociates from the receptor and interacts with SMAD4.
|protein kinase superfamily|
|Sequence:||3; NC_000003.12 (30606472..30694142)|
Cell membrane; Single-pass type I membrane protein. Membrane raft.
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