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Product Info Summary
| SKU: | A00750 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-DISC1 Antibody
SKU/Catalog Number
A00750
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DISC1 Antibody (Catalog # A00750). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
DISC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DISC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00750)
Host
Rabbit
Contents
DISC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DISC1 antibody was raised against an 18 amino acid synthetic peptide from near the center of human DISC1. The immunogen is located within amino acids 350 - 400 of DISC1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of DISC1 are known to exist; this antibody will detect the three longest isoforms.
Reactive Species
A00750 is reactive to DISC1 in Human, Mouse
Applications
A00750 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
93.611kDa
Background of DISC1
Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DISC1 antibody can be used for detection of DISC1 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DISC1 in SK-N-SH cell lysate with DISC1 antibody at (A) 0.5
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Immunocytochemistry of DISC1 in HeLa cells with DISC1 antibody at 5 μg/mL.
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Immunofluorescence of DISC1 in HeLa cells with DISC1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DISC1 (Source: Uniprot.org, NCBI)
Gene Name
DISC1
Full Name
Disrupted in schizophrenia 1 protein
Weight
93.611kDa
Alternative Names
C1orf136; DISC1; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9 DISC1 C1orf136, SCZD9 DISC1 scaffold protein disrupted in schizophrenia 1 protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DISC1, check out the DISC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DISC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DISC1 Antibody (A00750)
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No publications found for A00750
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Customer Reviews
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