Product Info Summary
SKU: | A08939 |
---|---|
Size: | 100μl |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, IHC, WB |
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Product info
Product Name
Anti-Gremlin-2 GREM2 Antibody
View all PRDC/GREM2 Antibodies
SKU/Catalog Number
A08939
Size
100μl
Form
Liquid
Description
Boster Bio Anti-Gremlin-2 GREM2 Antibody catalog # A08939. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Gremlin-2 GREM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08939)
Host
Rabbit
Contents
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Clonality
Polyclonal
Clone Number
3D5B1
Isotype
IgG
Immunogen
Synthetic peptide from human protein at AA range: 71-120.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A08939 is reactive to Grem2 in Human, Mouse
Applications
A08939 is guaranteed for ELISA, IF, IHC, WB Boster Guarantee
Observed Molecular Weight
39 kDa
Calculated molecular weight
19.334kDa
Background of PRDC/GREM2
APC11 is also known as Anaphase promoting complex subunit 11, APC11, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, and HSPC214. APC11 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC11 may function to recruit the E2 ubiquitin-conjugating enzymes to the complex. APC11 interacts with the cullin domain of ANAPC2 and also interacts with UBE2D2. APC11 shows both a cytoplasmic and nuclear localization. APC11 is expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. APC11 is a member of the RING-type zinc finger family and is auto-ubiquitinylated.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-2000
IHC-P 1:500-200
ELISA 1:10000-20000
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of mouse kidney, 293T mouse lung lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000.
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Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200.
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Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200.
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Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200.
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Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200.
Protein Target Info & Infographic
Gene/Protein Information For Grem2 (Source: Uniprot.org, NCBI)
Gene Name
Grem2
Full Name
Gremlin-2
Weight
19.334kDa
Superfamily
DAN family
Alternative Names
CKTSF1B2; CKTSF1B2FLJ21195; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; DAND3; DAND3Prdc; GREM2; gremlin 2; gremlin 2, cysteine knot superfamily, homolog; gremlin-2; PRDC; PRDCgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); Protein related to DAN and cerberus Grem2|Gremlin2, Pr, Prdc|gremlin 2, DAN family BMP antagonist|gremlin-2|Gremlin1|cysteine knot superfamily 1, BMP antagonist 2|gremlin 2 homolog, cysteine knot superfamily|protein related to DAN and cerberus
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Grem2, check out the Grem2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Grem2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Gremlin-2 GREM2 Antibody (A08939)
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No publications found for A08939
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Customer Reviews
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Customer Q&As
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5 Customer Q&As for Anti-Gremlin-2 GREM2 Antibody
Question
We need to test anti-Gremlin-2 antibody A08939 on mouse brain for research purposes, then I may be interested in using anti-Gremlin-2 antibody A08939 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2020-03-06
Answer
The products we sell, including anti-Gremlin-2 antibody A08939, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2020-03-06
Question
We are currently using anti-Gremlin-2 antibody A08939 for human tissue, and we are satisfied with the IHC results. The species of reactivity given in the datasheet says human, mouse. Is it possible that the antibody can work on feline tissues as well?
Verified Customer
Verified customer
Asked: 2020-02-20
Answer
The anti-Gremlin-2 antibody (A08939) has not been tested for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-02-20
Question
Is there a BSA free version of anti-Gremlin-2 antibody A08939 available?
Verified Customer
Verified customer
Asked: 2019-12-11
Answer
Thank you for your recent telephone inquiry. I can confirm that some lots of this anti-Gremlin-2 antibody A08939 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.
Boster Scientific Support
Answered: 2019-12-11
Question
Is this A08939 anti-Gremlin-2 antibody reactive to the isotypes of GREM2?
Verified Customer
Verified customer
Asked: 2019-08-29
Answer
The immunogen of A08939 anti-Gremlin-2 antibody is Synthetic peptide from human protein at AA range: 71-120. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2019-08-29
Question
I have attached the WB image, lot number and protocol we used for brain using anti-Gremlin-2 antibody A08939. Please let me know if you require anything else.
R. Krishna
Verified customer
Asked: 2018-06-08
Answer
Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.
Boster Scientific Support
Answered: 2018-06-08