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Product Info Summary
| SKU: | M01944 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Primate |
| Host: | Mouse |
| Application: | IHC-P, WB |
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Product info
Product Name
Anti-HLA-E Purified Monoclonal Antibody
SKU/Catalog Number
M01944
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-HLA-E Purified Monoclonal Antibody (Catalog# M01944). Tested in WB, IHC-P application(s). This antibody reacts with Human, Primate.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-HLA-E Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01944)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
MEM-E/02
Isotype
Mouse IgG1
Immunogen
Recombinant human HLA-E denaturated heavy chain. The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M01944 is reactive to HLA-E in Human, Primate
Applications
M01944 is guaranteed for IHC-P, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
40.058kDa
Background of HLA-E
HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (paraffin sections): 5-10 μg/ml; positive control: human placenta; heat antigen retrieval (sodium citrate), incubation with mAb: 1 hour / RT, detection DAB.
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For HLA-E (Source: Uniprot.org, NCBI)
Gene Name
HLA-E
Full Name
HLA class I histocompatibility antigen, alpha chain E
Weight
40.058kDa
Superfamily
MHC class I family
Alternative Names
Clone OX18; DKFZp686P19218; EA1.2; EA2.1; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; HLAE; lymphocyte antigen; major histocompatibility complex, class I, E; MHC class I antigen E; MHC Class I RT1-A; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; OX18; QA1; RT1-A (OX18); RT1-A HLA-E HLA-6.2, QA1 major histocompatibility complex, class I, E HLA class I histocompatibility antigen, alpha chain E|MHC class I antigen E|MHC class Ib antigen
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HLA-E, check out the HLA-E Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HLA-E: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HLA-E Purified Monoclonal Antibody (M01944)
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No publications found for M01944
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