Product Info Summary
SKU: | A04298-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-JAM-B JAM2 Antibody
View all JAM-B/VE-JAM Antibodies
SKU/Catalog Number
A04298-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-JAM-B JAM2 Antibody catalog # A04298-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-JAM-B JAM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04298-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human JAM-B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04298-1 is reactive to JAM2 in Human, Mouse, Rat
Applications
A04298-1 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
33.207kDa
Background of JAM-B/VE-JAM
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
Ortega A., J. Biol. Chem. 278:3040-3047(2003).
Nagase T., DNA Res. 2:37-43(1995).
Mungall A.J., Nature 425:805-811(2003).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of JAM2 using Anti-JAM-B JAM2 Antibody (A04298-1).
Immunohistochemistry (IHC) analysis of paraffin-embedded Rat LungClick image to see more details
Figure 3. Immunohistochemistry validation of JAM2 using Anti-JAM-B JAM2 Antibody (A04298-1).
Immunohistochemistry (IHC) analysis of paraffin-embedded Rat LungClick image to see more details
Figure 4. Immunohistochemistry validation of JAM2 using Anti-JAM-B JAM2 Antibody (A04298-1).
Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse LungClick image to see more details
Figure 5. Immunohistochemistry validation of JAM2 using Anti-JAM-B JAM2 Antibody (A04298-1).
Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse LungClick image to see more details
Figure 1. Western blotting validation for Anti-JAM-B JAM2 Antibody A04298-1
Western Blot (WB) analysis of K562 cells using JAM-B polyclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For JAM2 (Source: Uniprot.org, NCBI)
Gene Name
JAM2
Full Name
Junctional adhesion molecule B
Weight
33.207kDa
Superfamily
immunoglobulin superfamily
Alternative Names
C21orf43; CD322 antigen; CD322; JAM2; JAMB; JAM-B; JAM-BJAM-IT/VE-JAM; junctional adhesion molecule 2JAM-2; junctional adhesion molecule B; PRO245; Vascular endothelial junction-associated molecule; VE-JAM; VE-JAMVEJAMCD322 JAM2 C21orf43, CD322, IBGC8, JAM-B, JAMB, PRO245, VE-JAM, VEJAM junctional adhesion molecule 2 junctional adhesion molecule B|JAM-2|JAM-IT/VE-JAM|vascular endothelial junction-associated molecule
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on JAM2, check out the JAM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for JAM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-JAM-B JAM2 Antibody (A04298-1)
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No publications found for A04298-1
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Customer Reviews
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