Anti-JAM-B JAM2 Antibody

JAM-B/VE-JAM antibody

Boster Bio Anti-JAM-B JAM2 Antibody catalog # A04298-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A04298-1
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, IHC, WB

Product Name

Anti-JAM-B JAM2 Antibody

View all JAM-B/VE-JAM Antibodies

SKU/Catalog Number

A04298-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-JAM-B JAM2 Antibody catalog # A04298-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-JAM-B JAM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04298-1)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human JAM-B.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04298-1 is reactive to JAM2 in Human, Mouse, Rat

Applications

A04298-1 is guaranteed for ELISA, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

33.207kDa

Background of JAM-B/VE-JAM

Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.

Ortega A., J. Biol. Chem. 278:3040-3047(2003).
Nagase T., DNA Res. 2:37-43(1995).
Mungall A.J., Nature 425:805-811(2003).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000

Validation Images & Assay Conditions

Gene/Protein Information For JAM2 (Source: Uniprot.org, NCBI)

Gene Name

JAM2

Full Name

Junctional adhesion molecule B

Weight

33.207kDa

Superfamily

immunoglobulin superfamily

Alternative Names

C21orf43; CD322 antigen; CD322; JAM2; JAMB; JAM-B; JAM-BJAM-IT/VE-JAM; junctional adhesion molecule 2JAM-2; junctional adhesion molecule B; PRO245; Vascular endothelial junction-associated molecule; VE-JAM; VE-JAMVEJAMCD322 JAM2 C21orf43, CD322, IBGC8, JAM-B, JAMB, PRO245, VE-JAM, VEJAM junctional adhesion molecule 2 junctional adhesion molecule B|JAM-2|JAM-IT/VE-JAM|vascular endothelial junction-associated molecule

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on JAM2, check out the JAM2 Infographic

JAM2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for JAM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A04298-1-100ul

100ul

$380

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A04298-1
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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