Anti-Collagen I/COL1A1 Antibody

COL1A1 antibody

Boster Bio Anti-Collagen I/COL1A1 Antibody catalog # PA2140-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse Cited in 10 publication(s).

Product Info Summary

SKU: PA2140-1
Size: 100 μg/vial
Reactive Species: Human, Mouse
Host: Rabbit
Application: IHC, WB

Product Name

Anti-Collagen I/COL1A1 Antibody

View all COL1A1 Antibodies

SKU/Catalog Number

PA2140-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Collagen I/COL1A1 Antibody catalog # PA2140-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse

Storage & Handling

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Cite This Product

Anti-Collagen I/COL1A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2140-1)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen I, different from the related rat and mouse sequences by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2140-1 is reactive to COL1A1 in Human, Mouse

Applications

PA2140-1 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

180-200 kDa

Calculated molecular weight

138.941kDa

Background of COL1A1

Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5μg/ml, Human, Mouse
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, By Heat

Validation Images & Assay Conditions

Gene/Protein Information For COL1A1 (Source: Uniprot.org, NCBI)

Gene Name

COL1A1

Full Name

Collagen alpha-1(I) chain

Weight

138.941kDa

Superfamily

fibrillar collagen family

Alternative Names

Alpha-1 type I collagen; COL1A1; Collagen 1 alpha 1; Collagen 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain; Collagen I alpha 1; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; Collagen1; Collagen-1; OI4; pro-alpha-1 collagen type 1 COL1A1 CAFYD, EDSARTH1, EDSC, OI1, OI2, OI3, OI4 collagen type I alpha 1 chain collagen alpha-1(I) chain|alpha-1 type I collagen|alpha1(I) procollagen|collagen alpha 1 chain type I|collagen alpha-1(I) chain preproprotein|collagen of skin, tendon and bone, alpha-1 chain|collagen, type I, alpha 1|pro-alpha-1 collagen type 1|type I proalpha 1|type I procollagen alpha 1 chain

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on COL1A1, check out the COL1A1 Infographic

COL1A1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for COL1A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA2140-1 has been cited in 10 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Low expression of collagen type-1 in sacrouterine ligament as risk factor of stage III–IV uterine prolapse

Li X,Bu X,Yan F,Wang F,Wei D,Yuan J,Zheng W,Su J,Yuan J.Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis in a murine unilateral ureteral obstruction model.Ren Fail.2019 Nov;41(1):481-488.doi:10.1080/0886022X.2019.1621759.PMID:31169440;PMCID:PMC6567249.
Species: Mouse
PA2140-1 usage in article: APP:WB, SAMPLE:KIDNEY TISSUE, DILUTION:NA

Feng Y,Dong H,Sun B,Hu Y,Yang Y,Jia Y,Jia L,Zhong X,Zhao R.METTL3/METTL14 transactivation and m6A-dependent TGF-β1 translation in activated Kupffer cells.Cell Mol Gastroenterol Hepatol.2021 May 13:S2352-345X(21)00096-5.doi:10.1016/j.jcmgh.2021.05.007.Epub ahead of print.PMID:33992834.
Species: Human,Mouse,Rat
PA2140-1 usage in article: APP: WB, SAMPLE:LIVER TISSUE, DILUTION:1:500

Jiang Y,Liu JM,Huang JP,Lu KX,Sun WL,Tan JY,Li BX,Chen LL,Wu Y. Regeneration potential of decellularized periodontal ligament cell sheets combined with 15-Deoxy-Δ12,14-prostaglandin J2nanoparticles in a rat periodontal defect. Biomed Mater.2021 Mar 12.doi:10.1088/1748-605X/abee61.Epub ahead of print.PMID:33711827.
Species: Human,Rat
PA2140-1 usage in article: APP:IHC, SAMPLE:MANDIBLES, DILUTION:1:100

Lombardi, F.; Augello, F.R.; Palumbo, P.; Mollsi, E.; Giuliani, M.; Cimini, A.M.; Cifone, M.G.; Cinque, B. Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-β1-Induced Intestinal Fibrosis on CCD-18Co Cells. Nutrients 2021,13,882. https://doi.org/10.3390/nu13030882
Species: Human
PA2140-1 usage in article: APP:WB, SAMPLE:HUMAN INTESTINAL FIBROBLAST CELL, DILUTION:1:1000

Zhou J,Li R,Liu Q,Zhang J,Huang H,Huang C,Zhang G,Zhao Y,Wu T,Tang Q,Huang Y,Zhang Z,Li Y,He J. Blocking 5-LO pathway alleviates renal fibrosis by inhibiting the epithelial-mesenchymal transition. Biomed Pharmacother. 2021 Mar 12;138:111470.doi:10.1016/j.biopha.2021.111470.Epub ahead of print.PMID:33721755.
Species: Human,Mouse
PA2140-1 usage in article: APP:WB, SAMPLE:KIDNEY TISSUE AND TCMK-1 CELL, DILUTION:NA

Lan Chen,Xiaofang Ji,Manni Wang et al.Involvement of TLR4 Signaling Regulated-COX2/PGE2 Axis in Liver Fibrosis Induced by Schistosoma japonicum Infection, 06 January 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs
Species: Human,Mouse
PA2140-1 usage in article: APP:IHC, SAMPLE:LIVER TISSUE, DILUTION:1:400

Ma XL,Ding Y,Wu LM,Wang YX,Yao Y,Wang YX,Zhang YG,Niu JQ,He XX,Wang YQ.The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice.Peptides.2021 Jan 12;137:170481.doi:10.1016/j.peptides.2020.170481.Epub ahead of print.P
Species: Mouse
PA2140-1 usage in article: APP:WB, SAMPLE:IUA TISSUE, DILUTION:1:1000

Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins. Xin Zhen,Shaowu Zhang,Feifei Xie,Miaomiao Zhou,Zheng Hu,Fengxin Zhu,Jing Nie
Species: Mouse
PA2140-1 usage in article: APP:WB, SAMPLE:KIDNEY TISSUE AND PTCS, DILUTION:NA

Francesca Lombardi,Paola Palumbo,Francesca Rosaria Augello,Ilaria Giusti,Vincenza Dolo,Luca Guerrini,Maria Grazia Cifone,Maurizio Giuliani,Benedetta Cinque,"Type I Collagen Suspension Induces Neocollagenesis and Myodifferentiation in Fibroblasts In Vitro"
Species: Mouse
PA2140-1 usage in article: APP:IF, SAMPLE:NIH 3T3 CELL, DILUTION:1:250

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Order DetailsPrice
PA2140-1

100μg

$370
PA2140-1-10ug

10μg sample (liquid)

$99
PA2140-1-Biotin

100 μg Biotin conjugated

$570
PA2140-1-Cy3

100 μg Cy3 conjugated

$570
PA2140-1-Dylight488

100 μg Dylight488 conjugated

$570
PA2140-1-Dylight550

100 μg Dylight550 conjugated

$570
PA2140-1-Dylight594

100 μg Dylight594 conjugated

$570
PA2140-1-FITC

100 μg FITC conjugated

$570
PA2140-1-HRP

100 μg HRP conjugated

$570
PA2140-1-APC

100 μg APC conjugated

$670
PA2140-1-PE

100 μg PE conjugated

$670
PA2140-1-carrier-free

Carrier Free

$370

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PA2140-1
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