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Product Info Summary
| SKU: | A02172 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-Mitofusin-1 MFN1 Antibody
View all Mitofusin 1 Antibodies
SKU/Catalog Number
A02172
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Mitofusin-1 MFN1 Antibody (Catalog # A02172). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
MFN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Mitofusin-1 MFN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02172)
Host
Rabbit
Contents
MFN1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1. The immunogen is located within amino acids 20 - 70 of MFN1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.
Reactive Species
A02172 is reactive to MFN1 in Human, Mouse, Rat
Applications
A02172 is guaranteed for ELISA, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
84.16kDa
Background of Mitofusin 1
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MFN1 in A431 cell lysate with MFN1 antibody at 1 μg/ml.
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Immunocytochemistry of MFN1 in A431 cells with MFN1 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For MFN1 (Source: Uniprot.org, NCBI)
Gene Name
MFN1
Full Name
Mitofusin-1
Weight
84.16kDa
Superfamily
TRAFAC class dynamin-like GTPase superfamily
Alternative Names
DKFZp762F247; EC 3.6.5; EC 3.6.5.-; FLJ20693; Fzo homolog; hfzo1; hfzo2; MFN1; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitofusin 1; mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1 MFN1 hfzo1, hfzo2 mitofusin 1 mitofusin-1|fzo homolog|mitochondrial transmembrane GTPase FZO-2|mitochondrial transmembrane GTPase Fzo-1|putative transmembrane GTPase|transmembrane GTPase MFN1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MFN1, check out the MFN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MFN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Mitofusin-1 MFN1 Antibody (A02172)
Hello CJ!
A02172 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Jiao Z,Wu Y,Qu S.Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.Cell Death Discov.2020 Aug 25;6:78.doi:10.1038/s41420-020-00313-y.PMID:32884840;PMCID:PMC7447795.
Species: Mouse
A02172 usage in article: APP:WB, SAMPLE:BRAIN TISSUE, DILUTION:NA
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Customer Reviews
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