Anti-MRC2/Endo180 Antibody

Product Name

Anti-MRC2/Endo180 Antibody

View all MRC2 Antibodies

SKU/Catalog Number

A04070

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-MRC2/Endo180 Antibody (Catalog # A04070). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MRC2/Endo180 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04070)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human MRC2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04070 is reactive to MRC2 in Human, Mouse, Rat

Applications

A04070 is guaranteed for IF, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

166.674kDa

Background of MRC2

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Behrendt N., J. Biol. Chem. 275:1993-2002(2000).
Sheikh H., J. Cell Sci. 113:1021-1032(2000).
Howard M.J., J. Biol. Chem. 277:32320-32331(2002).<

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Validation Images & Assay Conditions

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Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRC2 antibody A04070.

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Western blot analysis of extracts from 293 cells, using MRC2 antibody A04070.

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Immunofluorescence analysis of HepG2 cells, using MRC2 antibody A04070.

Gene/Protein Information For MRC2 (Source: Uniprot.org, NCBI)

Alternative Names

CD280 antigen; CD280; CD280C-type mannose receptor 2; CLEC13E; CLEC13EUPAR-associated protein; Endo180; ENDO180C-type lectin domain family 13 member E; Endocytic receptor 180; KIAA0709FLJ35911; Macrophage mannose receptor 2; mannose receptor, C type 2; Mrc2; uPARAP; UPARAPendocytic receptor (macrophage mannose receptor family); urokinase plasminogen activator receptor-associated protein; Urokinase receptor-associated protein; Urokinase-type plasminogen activator receptor-associated protein MRC2 CD280, CLEC13E, ENDO180, UPARAP mannose receptor C type 2 C-type mannose receptor 2|C-type lectin domain family 13 member E|UPAR-associated protein|endocytic receptor (macrophage mannose receptor family)|endocytic receptor 180|macrophage mannose receptor 2|urokinase-type plasminogen activator receptor-associated protein

For more info on MRC2, check out the MRC2 Infographic

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In this infographic, you will see the following information for MRC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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