Product Info Summary
SKU: | A01176-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | Flow Cytometry, IF, IHC, ICC, WB |
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Product info
Product Name
Anti-SERCA2 ATP2A2 Antibody
View all SERCA2 ATPase Antibodies
SKU/Catalog Number
A01176-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-SERCA2 ATP2A2 Antibody catalog # A01176-1. Tested in WB,ICC/IF,IHC,Flow Cytometry applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-SERCA2 ATP2A2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01176-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Hrs around the phosphorylation site of Y334.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01176-1 is reactive to ATP2A2 in Human, Mouse, Rat
Applications
A01176-1 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
114.757kDa
Background of SERCA2 ATPase
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
ShunJiang Yu, J. Biol. Chem., May 2003; 278: 19597 - 19602.
TT Chen, Mol. Cell. Biol., Jun 1997; 17: 3056 - 3064.
Oscar B. Goodman, J. Biol. Chem., Oct 1995; 270: 23768.
Didier Jean, J. Biol. Chem., Jun 1998; 273: 16501
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1,000
ICC: 1:50-1:200
IHC: 1:50-1:200
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunocytochemistry staining of ATP2A2 using Anti-SERCA2 ATP2A2 Antibody (A01176-1).
ICC staining SERCA2 in A549 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 2. Immunocytochemistry staining of ATP2A2 using Anti-SERCA2 ATP2A2 Antibody (A01176-1).
ICC staining SERCA2 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeProtein Target Info & Infographic
Gene/Protein Information For ATP2A2 (Source: Uniprot.org, NCBI)
Gene Name
ATP2A2
Full Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Weight
114.757kDa
Superfamily
cation transport ATPase (P-type) (TC 3.A.3) family
Alternative Names
ATP2BFLJ20293; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletalmuscle isoform; cardiac Ca2+ ATPase; DAR; DD; EC 3.6.3; EC 3.6.3.8; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; FLJ38063; MGC45367; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2DKFZp686P0211; SR Ca(2+)-ATPase 2 ATP2A2 ATP2B, DAR, DD, SERCA2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 sarcoplasmic/endoplasmic reticulum calcium ATPase 2|ATPase Ca++ transporting cardiac muscle slow twitch 2|ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2|SR Ca(2+)-ATPase 2|calcium pump 2|cardiac Ca2+ ATPase|endoplasmic reticulum class 1/2 Ca(2+) ATPase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ATP2A2, check out the ATP2A2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ATP2A2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SERCA2 ATP2A2 Antibody (A01176-1)
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No publications found for A01176-1
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