Product Info Summary
SKU: | A00131-1 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Toll-like receptor 2 TLR2 Antibody
SKU/Catalog Number
A00131-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Toll-like receptor 2 TLR2 Antibody (Catalog # A00131-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
TLR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Toll-like receptor 2 TLR2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00131-1)
Host
Rabbit
Contents
TLR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TLR2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TLR2. The immunogen is located within the first 50 amino acids of TLR2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This polyclonal antibody has no cross response to IKKa or IKKy.
Reactive Species
A00131-1 is reactive to TLR2 in Human, Mouse
Applications
A00131-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
89.838kDa
Background of TLR2
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κB. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins respectively.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TLR2 antibody can be used for detection of TLR2 by Western blot at 1 μg/mL. Despite its predicted molecular weight, TLR2 runs at ~100 kDa in SDS-PAGE. This polyclonal antibody can also detect TLR2 by immunohistochemistry at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of TLR2 in A20 cell lysates with TLR2 antibody at 1 μg/mL in the presence (A) and absence (B) of its blocking peptide.
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Immunohistochemical staining of human spleen cells using TLR2 antibody at 2 μg/mL.
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Immunofluorescence of TLR2 in Human Spleen tissue with TLR2 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TLR2 (Source: Uniprot.org, NCBI)
Gene Name
TLR2
Full Name
Toll-like receptor 2
Weight
89.838kDa
Superfamily
Toll-like receptor family
Alternative Names
CD282 antigen; CD282; TIL4CD282; TLR2; toll/interleukin 1 receptor-like 4; Toll/interleukin-1 receptor-like protein 4; toll-like receptor 2 TLR2 CD282, TIL4 toll like receptor 2 toll-like receptor 2|toll/interleukin-1 receptor-like protein 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TLR2, check out the TLR2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TLR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Toll-like receptor 2 TLR2 Antibody (A00131-1)
Hello CJ!
A00131-1 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Feng S,Ju L,Shao Z,Grzanna M,Jia L,Liu M.Therapeutic Effect of C-C Chemokine Receptor Type 1 (CCR1) Antagonist BX471 on Allergic Rhinitis.J Inflamm Res.2020 Jul 21;13:343-356.doi:10.2147/JIR.S254717.PMID: 32801828;PMCID:PMC7398876.
Species: Mouse
A00131-1 usage in article: APP:WB, SAMPLE:SPLEEN, DILUTION:NA
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