Apoptosis-inducing factor 1, mitochondrial (AIFM1)

In response to apoptotic stimuli, it's released from the mitochondrion intermembrane space to the cytosol and into the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity.

The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e.