Androgen receptor Antibodies

Androgen receptor (AR)

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins.

Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

Gene Information

Human
Gene Name:	AR
Uniprot:	P10275
Entrez:	367

Family

Belongs to:
nuclear hormone receptor family

Alternative Names

AIS; Androgen R; androgen receptor; AndrogenR; AR; DHTR; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; NR3C4; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; SMAX1SBMA; spinal and bulbar muscular atrophy

Molecular Weight

Mass (kDA):
99.188 kDA

Genomic Context

Human
Location:	Xq12
Sequence:	X; NC_000023.11 (67544021..67730619)

Tissue Specificity

Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).

Subcellular Localizations

Nucleus. Cytoplasm. Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Prostate
• Prostatic Neoplasms
• Neoplasms
• Carcinoma
• Mammary Neoplasms
• Rhinorrhea
• Malignant Neoplasm Of Breast
• Allergic Rhinitis (disorder)
• Regurgitation
• Inflammation
• Aortic Valve Insufficiency
• Hyperplasia

• Diabetes Mellitus
• Neoplasm Metastasis
• Asthma
• Testicular Feminization
• Adenocarcinoma
• Malignant Paraganglionic Neoplasm
• Neoplasms, Hormone-dependent

Pathways

• Cell Proliferation
• Localization
• Acrosome Reaction
• Cell Growth
• Pathogenesis
• Secretion
• Cell Cycle
• Transport
• Fertilization
• Cell Death
• Spermatogenesis
• Methylation
• Aging

• Sensitization
• Reflex
• Angiogenesis
• Translation
• Sperm Capacitation
• Sperm Motility
• Immune Response

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Oxidation
• Acetylation
• Reduction
• Ubiquitination
• Glycosylation
• Sumoylation
• Carboxylation

• Nitration
• Demethylation
• Hydroxylation
• Dephosphorylation
• Iodination
• Biotinylation
• Deacetylation
• Ribosylation
• Phosphorothioation
• Amidation

Research Areas

• Breast Cancer
• Cancer
• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AR

Best Uses Of The AR Marker

The AR Marker is an extremely versatile tool in molecular biology research. The AR-marker can be employed in a wide variety of experimental settings and its numerous applications in a variety of areas of science have been widely acknowledged and appreciated. Boster offers comprehensive technical information, blogs, disease information, web-based digital tools, and lysis buffers of high-quality that ensure high quality results. In addition Boster's lysis buffers are also distinguished by their ability to reduce cross-linking intensity.

Boster Bio's primary and secondary antibodies are available for research

Boster Bio's antibodies are ideal for studying cell behavior, gene expression and molecular interactions. They are available in a variety formats and can be used for various applications like IHC, WB or FC. Boster Bio also offers rabbit polyclonal antibody as well as a complimentary secondary antibody when you purchase a primary antibody. Furthermore, Boster Bio provides antibodies for human and mouse samples, making it simpler to find the ideal antibody for your research. The quality of the antibodies is guaranteed by a Boster Quality Guarantee, which assures that every product is as good as it claims to be.

Boster provides superior secondary and primary antibodies for research. Boster also offers ELISA kit and phospho-antibodies. ELISA kits are commonly utilized in biochemistry experiments. ELISA kits detect a specific ligand after it has been immobilized onto the polystyrene plate with 96 wells. The antibody is used to identify the ligand. Boster Bio's primary and secondary research antibodies are created using proprietary technology. This ensures high-quality and effectiveness.

Primary antibodies are perfect for experiments that require a single agent and identical results. Furthermore, they have a reduced background staining , and decrease the chance of cross-reactions. Primary antibodies can also detect small differences in an antigen. They are also ideal for detecting biomarkers, which may differ from protein to protein. Before you begin your study, it is important that you know your target.

Global Secondary Antibody Market Report by Mr Accuracy Reports provides comprehensive information about the competitive landscape, which includes the major players, their products , and their value. It also includes a SWOT analysis of companies in order to determine whether they can stay competitive and successfully compete. The report is updated regularly to provide the most up-to-date information. The Global Secondary Antibody Market Report is the most comprehensive guide for scientists and investors.

PICOKINE(tm), ELISA kits

The AR Marker is a biomarker that is highly sensitive and can be used in genetic analyses. This marker is utilized in molecular biology techniques such as DNA manipulation to determine the genetic structure of a particular sample or species. Boster offers a wide range of technical resources, including blogs, information on diseases and digital tools for genetic analysis. Furthermore, Boster offers high-quality lysis buffers for DNA manipulation that can help scientists obtain top-quality results and minimize cross-linking intensity.

For those who are unfamiliar with immunohistochemistry, BosterBio's guide provides step-by-step instructions with illustrations. The guide contains detailed guidelines for preparation of samples as well as a detailed step-by-step process. Boster also provides comprehensive information on disease-related information and tips to troubleshoot any problems with immunostaining. For a comprehensive resource on technical issues read the Boster's blog as well as follow his YouTube channel.

Techniques in molecular biology

The AR marker is a powerful tool for identifying polymorphisms as well as creating genetic maps. These techniques are particularly useful in determining differences between markers for certain traits. Differences between markers are an accurate measure of the genetic determination of traits. They also establish the degree of connection between an QTL and a marker. MAS is costly, but it is worth it for traits that haven't been subjected to traditional selection.

However this marker has a number of disadvantages. Contrary to other techniques which require screening genomic libraries and random amplified DNA for sequences of the AR gene. Furthermore, it is vulnerable to errors and laborious. Researchers do not have any information about the genome, including the percentage of AT/GC bases and the amount of repetitive genes. Thus, it is essential to conduct a comprehensive genome-wide analysis of genetic variation by using genetic markers.

Protein electrophoresis is yet another method that is used to determine the molecular weight. Electrophoresis is the process of moving an array of proteins through the gel. These proteins are known as protein ladders or size standard and are the most mass range. There are numerous types of molecular markers. It is essential to realize that every method has its own limitations. Before you begin the analysis, be sure the protein is of a known mass.

To improve the physical models of complex molecules or proteins, a multi-institutional collaborative project was created. These tools will be included in the PMV-based molecular viewers that allow users to interact with 3D graphic information as well as feedback via haptic. This project will create lessons and analyze their impact on learning for students. The AR marker is vital to molecular biology's future.

In the near future, scientists will be able create replicas of proteins with these methods. These models will be color-coded according to the atom, peptide chain residue, or secondary structure. These models are then put together into larger models such as DNA base assemblies as well as beta strands of protein. These methods can also be used to construct biological models of molecules. It's also an excellent method of analyzing gene expression levels and gene structures.