Bcl-2-interacting killer Antibodies

AND BIK ELISA kits, Bcl-2-interacting killer Proteins

Many biological assays use antibodies to detect Bcl-2-interacting killer, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bcl-2-interacting killer in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bcl-2-interacting killer antibodies...

We validate the specificity of these antibodies to Bcl-2-interacting killer by testing them on tissues known to express BIK positively and negatively. Browse below to find the BIK antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BIK Infographic by Boster Bio

All BIK Products

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Anti-Bik Antibody Picoband®

7 Q&As

Western blot analysis of Bik using anti-Bik antibody (PB9755)

IHC analysis of Bik using anti-Bik antibody (PB9755)

Human, Mouse, Rat

Flow Cytometry, IHC, ICC, WB

$370
Cat # PB9755
100 μg/vial

BIK Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from HuvEc/COLO205

Human

ELISA

$480
Cat # EKC1060
1 kit, containing one 96-well plate and all necessary reagents

BIK (Phospho-Thr33) Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from K562 cells

Human

ELISA

$540
Cat # EKC1971
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-NBK (T33) BIK Antibody

Western blot analysis of lysates from K562 cells, using BIK (Phospho-Thr33) Antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using BIK (Phospho-Thr33) Antibody

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using BIK (Phospho-Thr33) Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A03188T33
100ul

Anti-Phospho-NBK (S35) BIK Antibody

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A03188S35
100ul

Anti-BIK Antibody (Monoclonal, 31B31)

Human

IP, IF, ICC, WB

$370
Cat # M03188
100 μl/vial

BIK Overview

Facts about Bcl-2-interacting killer.

BIK 3D structure. Source: alphafold

Bcl-2-interacting killer (BIK)

Accelerates programmed cell death. Association into the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting action.

Does not interact with BAX. .

Gene Information

Human
Gene Name:	BIK
Uniprot:	Q13323
Entrez:	638

Family

Belongs to:

No superfamily

Alternative Names

Apoptosis inducer NBK; BCL2-interacting killer (apoptosis-inducing); bcl-2-interacting killer; BIK; BIP1; BP4; NBK; NBKapoptosis-inducing NBK

Molecular Weight

Mass (kDA):
18.016 kDA

Genomic Context


Human

Location:	22q13.2
Sequence:	22; NC_000022.11 (43110750..43129712)

Subcellular Localizations

Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Around the nuclear envelope, and in cytoplasmic membranes.

Diseases

Malignant Neoplasms
Neoplasms
Lymphoma
Carcinoma
Malignant Neoplasm Of Breast
Mammary Neoplasms
Malignant Tumor Of Colon
Colonic Neoplasms
Neoplasm Metastasis
Malignant Paraganglionic Neoplasm
Multiple Myeloma
Leukemia

Prostatic Neoplasms
B-cell Lymphomas
Malignant Neoplasm Of Lung
Malignant Neoplasm Of Prostate
Liver Carcinoma
Virus Diseases
Endoplasmic Reticulum Stress

Interacting Proteins

BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2

FATE1

Pathways

Cell Death
Cell Cycle
Induction Of Apoptosis
Localization
Cell Proliferation
Programmed Cell Death
Methylation
Dna Methylation
Translation
Autophagy
Cell Cycle Arrest
Cell Growth
Release Of Cytochrome C From Mitochondria

Drug Resistance
Rna Interference
Secretion
Histone Acetylation
Cell Differentiation
Dna Repair
Mitochondrial Fission

PTMs

Cleavage
Phosphorylation
Methylation
Acetylation
Deacetylation

Demethylation
Biotinylation
Hydroxylation
Glycosylation
Dephosphorylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIK

References

PMID: 7478623 by Boyd J.M., et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

PMID: 8816500 by Han J., et al. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.