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- Table of Contents
CD274 Antibodies
AND CD274 ELISA kits, CD274 Proteins
Many biological assays use antibodies to detect CD274, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD274 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD274 antibodies...
Designing a Western blot for CD274? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CD274 Western Blot GuideCD274 Infographic by Boster Bio
All CD274 Products
Product
Figures
Specificity
Applications
Price
Mouse PD-L1/B7-H1 ELISA Kit PicoKine®
5 Citations
Mouse
ELISA
$499
Cat # EK1450
96 wells/kit, with removable strips.
Cat # EK1450
96 wells/kit, with removable strips.
Human PD-L1/B7-H1 ELISA Kit PicoKine®
1 Citations
Human
ELISA
$499
Cat # EK1449
96 wells/kit, with removable strips.
Cat # EK1449
96 wells/kit, with removable strips.
Anti-PD-L1 (CD274) Rabbit Monoclonal Antibody
7 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00109
100 μl
Cat # M00109
100 μl
Anti-PD-L1/CD274 Antibody Picoband®
1 Citations
Human
Flow Cytometry, WB
$370
Cat # PB9154
100 μg/vial
Cat # PB9154
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC-P, WB
$481
Cat # A00109-1
0.1 mg
Cat # A00109-1
0.1 mg
Human, Mouse
ELISA, IF, IHC-P, ICC, WB
$481
Cat # M00109-3
0.1 mg
Cat # M00109-3
0.1 mg
Human
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$481
Cat # M00109-2
0.1 mg
Cat # M00109-2
0.1 mg
Human
IHC, ICC, WB
$491
Cat # M00109-1
100uL
Cat # M00109-1
100uL
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-6
100 μg
Cat # M00109-6
100 μg
Dog, Human, Mouse, Rabbit, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-7
100 μg
Cat # M00109-7
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-9
100 μg
Cat # M00109-9
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-8
100 μg
Cat # M00109-8
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-10
100 μg
Cat # M00109-10
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-20
100 μg
Cat # M00109-20
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-19
100 μg
Cat # M00109-19
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-18
100 μg
Cat # M00109-18
100 μg
Cynomolgus monkey, Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-17
100 μg
Cat # M00109-17
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-16
100 μg
Cat # M00109-16
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-15
100 μg
Cat # M00109-15
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-14
100 μg
Cat # M00109-14
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-13
100 μg
Cat # M00109-13
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-12
100 μg
Cat # M00109-12
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00109-11
100 μg
Cat # M00109-11
100 μg
CD274 Overview
Facts about Programmed cell death 1 ligand 1.
Programmed cell death 1 ligand 1 (CD274)
Plays a crucial role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and restricts T-cell effector response (PubMed:11015443).
The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
Gene Information
| Human | |
|---|---|
| Gene Name: | CD274 |
| Uniprot: | Q9NZQ7 |
| Entrez: | 29126 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
B7-H; B7H1; B7-H1; B7H1PDCD1L1; CD274 antigenMGC142294; CD274 molecule; CD274; PDCD1L1; PDCD1LG1; PDCD1LG1MGC142296; PDL1; PD-L1; PD-L1B7 homolog 1; PDL1PDCD1 ligand 1; programmed cell death 1 ligand 1; Programmed death ligand 1
Molecular Weight
Mass (kDA):
33.275 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p24.1 |
| Sequence: | 9; NC_000009.12 (5450503..5470567) |
Tissue Specificity
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Endomembrane system; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Autoimmune Reaction
- Carcinoma
- Virus Diseases
- Inflammation
- Infective Disorder
- Autoimmune Diseases
- Tumor Escape
- Hepatitis
- Decreased Immunologic Activity [pe]
- Exhaustion
- Diabetes Mellitus
Interacting Proteins
- CD80
- CMTM4
- CMTM6
- PDCD1
Pathways
- Cytokine Production
- Immune Response
- Cell Activation
- T Cell Activation
- Cell Death
- Cell Proliferation
- Secretion
- Programmed Cell Death
- T Cell Proliferation
- Pathogenesis
- Inflammatory Response
- Cytokine Secretion
- Sensitization
PTMs
- Phosphorylation
- Reduction
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD274
bosterbio.com/bosterbio-gene-info-cards/CD274
References
PMID: 10581077 by Dong H., et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
PMID: 11015443 by Freeman G.J., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.
6 Publications of Boster CD274 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s00005-019-00539-4, PD-L1 Ameliorates Murine Acute Graft-Versus-Host Disease by Suppressing Effector...
- PubMed ID: , FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activati...
- PubMed ID: 33152901, He J,Zhang W,Di T,Meng J,Qi Y,Li G,Zhang Y,Su H,Yan W.Water extract of sporoderm...
- PubMed ID: 30927016 , PD-L1 Ameliorates Murine Acute Graft-Versus-Host Disease by Suppressing Effector...
- PubMed ID: 30359281, CD25 and TGF-%u03B2 blockade based on predictive integrated immune ratio inhibit...
- PubMed ID: 28599483, Liu ZH, Zheng FF, Mao YL, Ye LF, Bian J, Lai DH, Ye YL, Dai YP. Oncol Lett. 2017...
*More publications can be found for each product on its corresponding product page