This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Cytochrome P450 3A4 Antibodies
AND CYP3A4 ELISA kits, Cytochrome P450 3A4 Proteins
Many biological assays use antibodies to detect Cytochrome P450 3A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 3A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 3A4 antibodies...
Previous: CCN2
Next: CYP3A5
CYP3A4 Infographic by Boster Bio
All CYP3A4 Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$370
Cat # PB10055
100 μg/vial
Cat # PB10055
100 μg/vial
Human
ELISA
$480
Cat # EKC1920
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1920
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00339-2
100 μg/vial
Cat # A00339-2
100 μg/vial
Human
Flow Cytometry, WB
$370
Cat # A00339-3
100 μg/vial
Cat # A00339-3
100 μg/vial
Human
$628
Cat # LS001576
100 µg
Cat # LS001576
100 µg
CYP3A4 Overview
Facts about Cytochrome P450 3A4.
Cytochrome P450 3A4 (CYP3A4)
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.
It performs many different oxidation reactions (e.g.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP3A4 |
| Uniprot: | P08684 |
| Entrez: | 1576 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
Albendazole Monooxygenase; Albendazole Sulfoxidase; CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; Cytochrome P450-PCN1; EC 1.14.13.32; EC 1.14.13.67; EC 1.14.13.97; EC 1.14.14.1; glucocorticoid-inducible P450; HLP; MGC126680; NF-25; Nifedipine oxidase; P450C3; P450-III, steroid inducible; P450PCN1; Quinine 3-
Molecular Weight
Mass (kDA):
57.343 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (99756967..99784184, complement) |
Tissue Specificity
Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Carcinoma
- Malignant Neoplasm Of Breast
- Liver Carcinoma
- Food-drug Interactions
- Immunologic Deficiency Syndromes
- Hypertensive Disease
- Diabetes Mellitus
- Mammary Neoplasms
- Pain
- Depressive Disorder
Pathways
- Transport
- Excretion
- Secretion
- Conjugation
- Demethylation
- Platelet Aggregation
- Intestinal Absorption
- Drug Resistance
- Pathogenesis
- Cell Proliferation
- Drug Transport
- Localization
- Dna Repair
PTMs
- Hydroxylation
- Oxidation
- Demethylation
- Reduction
- Cleavage
- Phosphorylation
- Deacetylation
- Acetylation
- Methylation
- Ubiquitination
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP3A4
bosterbio.com/bosterbio-gene-info-cards/CYP3A4
References
PMID: 3460094 by Molowa D.T., et al. Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
PMID: 3267210 by Gonzalez F.J., et al. Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
1 Publications of Boster Cytochrome P450 3A4 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0238810, Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea bu...
*More publications can be found for each product on its corresponding product page