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- Table of Contents
Cyclin-dependent kinase 6 Antibodies
AND CDK6 ELISA kits, Cyclin-dependent kinase 6 Proteins
Many biological assays use antibodies to detect Cyclin-dependent kinase 6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-dependent kinase 6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-dependent kinase 6 antibodies...
Designing a Western blot for Cyclin-dependent kinase 6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CDK6 Western Blot GuideDesigning an IHC experiment for Cyclin-dependent kinase 6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CDK6 IHC GuideCDK6 Infographic by Boster Bio
All CDK6 Products
Product
Figures
Specificity
Applications
Price
Anti-CDK6 Rabbit Monoclonal Antibody
2 Citations
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00358
100 μl
Cat # M00358
100 μl
Human, Mouse, Rat
WB
$370
Cat # PA2125-2
100 μg/vial
Cat # PA2125-2
100 μg/vial
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00358-2
20μL, 40μL, 100μL, 200μL
Cat # M00358-2
20μL, 40μL, 100μL, 200μL
CDK6 Overview
Facts about Cyclin-dependent kinase 6.
Cyclin-dependent kinase 6 (CDK6)
Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase in G1 to form a pRB/RB1 kinase and controls the entry into the cell cycle.
Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is necessary for the proliferation of specific cell types (e.g.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK6 |
| Uniprot: | Q00534 |
| Entrez: | 1021 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Cell division protein kinase 6; cyclin-dependent kinase 6; EC 2.7.11; EC 2.7.11.22; PLSTIREMGC59692; Serine/threonine-protein kinase PLSTIRE
Molecular Weight
Mass (kDA):
36.938 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q21.2 |
| Sequence: | 7; NC_000007.14 (92604921..92836573, complement) |
Tissue Specificity
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
Subcellular Localizations
Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663).
Diseases
- Malignant Neoplasms
- Neoplasms
- Retinoblastoma
- Carcinoma
- Cell Transformation, Neoplastic
- Leukemia
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Growth Arrest
- Lymphoma
- Melanoma
- Malignant Squamous Cell Neoplasm
Interacting Proteins
- CCND1
- CCND3
- CCNH
- CDC37
- CDKN1A
- CDKN1B
- CDKN2A
- CDKN2B
- CDKN2C
- CDKN2D
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Cycle Arrest
- G1 Phase
- Cell Growth
- S Phase
- Cell Death
- Cell Division
- Senescence
- Pathogenesis
- Localization
- Induction Of Apoptosis
- Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Dephosphorylation
- Acetylation
- Ubiquitination
Research Areas
- Cell Cycle and Replication
- Ovarian Carcinoma Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK6
bosterbio.com/bosterbio-gene-info-cards/CDK6
References
PMID: 1639063 by Meyerson M., et al. A family of human cdc2-related protein kinases.
PMID: 8114739 by Meyerson M., et al. Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
7 Publications of Boster Cyclin-dependent kinase 6 Antibodies & ELISA Kits
- PubMed ID: 10.1186/s13046-016-0297-z, Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulat...
- PubMed ID: 34144025, Sun D,Zhao T,Long K,Wu M,Zhang Z.Triclosan down-regulates fatty acid synthase th...
- PubMed ID: 27065079, TALENs-directed?knockout?of the?full-length?transcription?factor?Nrf1? that?repr...
- PubMed ID: 26822763, Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulat...
- PubMed ID: 28081541, Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R, Guo J. Br J Cancer. 2017 Feb 28;...
- PubMed ID: 25734831, Ren J, Huang Q, Xu Y, Yang M, Yang J, Hu K. Anticancer Drugs. 2015 Jul;26(6):599...
- PubMed ID: 25431082, Zhou R, Lu Z, Liu K, Guo J, Liu J, Zhou Y, Yang J, Mi M, Xu H. Curr Cancer Drug ...
*More publications can be found for each product on its corresponding product page