This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Krueppel-like factor 1.
Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Moreover, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes.
| Human | |
|---|---|
| Gene Name: | KLF1 |
| Uniprot: | Q13351 |
| Entrez: | 10661 |

| Belongs to: |
|---|
| krueppel C2H2-type zinc-finger protein family |

EKLFerythroid-specific transcription factor EKLF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; HBFQTL6; INLU; Krueppel-like factor 1; Kruppel-like factor 1 (erythroid); monoclonal A3D8
Mass (kDA):
38.221 kDA

| Human | |
|---|---|
| Location: | 19p13.13 |
| Sequence: | 19; NC_000019.10 (12884422..12887201, complement) |
Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
Nucleus. Colocalizes with SUMO1 in nuclear speckles.






PMID: 8924208 by Bieker J.J.; Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF).
PMID: 9119377 by van Ree J.H., et al. The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.