Lipase member I Antibodies

AND LIPI ELISA kits, Lipase member I Proteins

Many biological assays use antibodies to detect Lipase member I, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lipase member I in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lipase member I antibodies...

We validate the specificity of these antibodies to Lipase member I by testing them on tissues known to express LIPI positively and negatively. Browse below to find the LIPI antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIPI Infographic by Boster Bio

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Anti-LPD lipase LIPI Antibody

Western Blot analysis of various cells using LPD lipase Polyclonal Antibody

Western blot analysis of lysates from COLO cells, using LIPI Antibody

Western blot analysis of the lysates from HepG2 cells using LIPI antibody

Human

ELISA, IF, IHC, WB

$380
Cat # A08196-1
100ul

LIPI Overview

Facts about Lipase member I.

LIPI 3D structure. Source: alphafold

Lipase member I (LIPI)

Hydrolyzes especially phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Doesn't hydrolyze other phospholipids, such as phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Gene Information

Human
Gene Name:	LIPI
Uniprot:	Q6XZB0
Entrez:	149998

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

Cancer/testis antigen 17; CT17; CT17membrane-associated phospholipase A1 beta; EC 3.1.1; EC 3.1.1.-; EC 3.1.1.3; EC 3.1.1.34; Lipase I; lipase, member I; LIPI; LPD lipase; LPDL; LPDLlipase member I; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta; PRED5

Molecular Weight

Mass (kDA):
52.922 kDA

Genomic Context


Human

Location:	21q11.2
Sequence:	21; NC_000021.9 (14108813..14210955, complement)

Tissue Specificity

Expressed in testis. Expressed exclusively at the connecting piece of the sperm.

Subcellular Localizations

[Isoform 1]: Membrane. Secreted. May associate with lipid draft.; [Isoform 2]: Membrane. Secreted. May associate with lipid draft.

Diseases

Neoplasms
Dyslipidemias
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Coronary Heart Disease
Thyroid Diseases
Bone Neoplasms
Hyperlipoproteinemia Type Iv
Insulin Resistance
Cardiovascular Diseases
Multiple Myeloma
Nervousness

Impaired Glucose Tolerance
Fatty Liver
Hypothyroidism
Atherosclerosis
Hyperthyroidism
Hypertensive Disease

Pathways

Response To Oxidative Stress
Glucose Homeostasis
Coagulation
Pathogenesis

PTMs

Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIPI

References

PMID: 12963729 by Hiramatsu T., et al. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.

PMID: 12719377 by Wen X.-Y., et al. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans.