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- Table of Contents
Prominin-1 Antibodies
AND PROM1 ELISA kits, Prominin-1 Proteins
Many biological assays use antibodies to detect Prominin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prominin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prominin-1 antibodies...
Designing a Western blot for Prominin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PROM1 Western Blot GuidePROM1 Infographic by Boster Bio
All PROM1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01767-3
100 μg/vial
Cat # A01767-3
100 μg/vial
Human, Mouse
Flow Cytometry, WB
$370
Cat # M01767-3
100 μg/vial
Cat # M01767-3
100 μg/vial
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M01767-7
20μL, 40μL, 100μL, 200μL
Cat # M01767-7
20μL, 40μL, 100μL, 200μL
PROM1 Overview
Facts about Prominin-1.
Prominin-1 (PROM1)
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells.
During early retinal development functions as a key regulator of disc morphogenesis. Involved in regulation of MAPK and Akt signaling pathways.
Gene Information
| Human | |
|---|---|
| Gene Name: | PROM1 |
| Uniprot: | O43490 |
| Entrez: | 8842 |
Family
| Belongs to: |
|---|
| prominin family |
Alternative Names
AC133 Stargardt disease 4 (autosomal dominant); AC133; CD133 retinal 2; CD133; PROM1; prominin (mouse)-like 1; Prominin 1; PROML1
Molecular Weight
Mass (kDA):
97.202 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p15.32 |
| Sequence: | 4; NC_000004.12 (15968226..16084059, complement) |
Tissue Specificity
Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
Diseases
- Malignant Neoplasms
- Neoplasms
- Retinitis Pigmentosa
- Malignant Tumor Of Colon
- Colorectal Cancer
- Neoplasm Metastasis
- Age Related Macular Degeneration
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Cell Invasion
- Dystrophy
- Colonic Neoplasms
Interacting Proteins
- Cdhr1
- HDAC6
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Development
- Neurogenesis
- Localization
- Cell Growth
- Cell Adhesion
- Cell Dedifferentiation
- Cell Migration
- Fertilization
- Brain Development
- Glycosylation
- Methylation
PTMs
- Phosphorylation
- Glycosylation
Research Areas
- Cellular Markers
- Core ESC-Like Genes
- Hematopoietic Stem Cell Markers
- Neuronal Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PROM1
bosterbio.com/bosterbio-gene-info-cards/PROM1
References
PMID: 9389721 by Miraglia S., et al. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning.
PMID: 12042327 by Yu Y., et al. AC133-2, a novel isoform of human AC133 stem cell antigen.
22 Publications of Boster Prominin-1 Antibodies & ELISA Kits
- PubMed ID: PMID:30210698, Identification and differentiation therapy strategy of pterygium in vitro
- PubMed ID: 10.7150/thno.13532, Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Effi...
- PubMed ID: 10.5114/fn.2018.76615, The impact of bone marrow-derived mesenchymal stem cells on neovascularisation i...
- PubMed ID: 10.3892/or_00000761, Characterization of primary ovarian cancer cells in different culture systems
- PubMed ID: 10.3892/ijo.2014.2448, β-elemene inhibits stemness, promotes differentiation and impairs chemoresistan...
- PubMed ID: 10.1371/journal.pone.0084358, Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human En...
- PubMed ID: 10.1016/j.tranon.2016.12.002, Immunotherapy with Dendritic Cells Modified with Tumor-Associated Antigen Gene D...
- PubMed ID: 10.1016/j.jocn.2018.07.011, Endothelial progenitor cells improve functional recovery in focal cerebral ische...
- PubMed ID: 10.1016/j.canlet.2017.11.033, Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding ...
- PubMed ID: , Multifunctional liposomes loaded with paclitaxel and artemether for treatment of...
- PubMed ID: , Untangling the response of bone tumor cells and bone forming cells to matrix sti...
- PubMed ID: , Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1 �...
- PubMed ID: 31147892, Yawata T,Higashi Y,Kawanishi Y,Nakajo T,Fukui N,Fukuda H,Ueba T.CD146 is highly ...
- PubMed ID: 32410622, Wang X,Zhou W,Li X,Ren J,Ji G,Du J,Tian W,Liu Q,Hao A. Graphene oxide suppresses...
- PubMed ID: 29196129 , Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding ...
- PubMed ID: 27486877, A three-dimensional collagen scaffold cell culture system for screening anti-gli...
- PubMed ID: 26563263, Reversion of malignant phenotypes of human glioblastoma cells by ?-elemene throu...
- PubMed ID: 26355082, Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepa...
- PubMed ID: 26877777, Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Effi...
- PubMed ID: 24392129, Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human En...
- PubMed ID: 27991692, Man S1, Li J1, Qiu P1, Liu J1, Liu Z1, Ma L1, Gao W2.Mol Carcinog. 2016 Dec 19. ...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page