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- Table of Contents
RIPK1 Antibodies
AND RIPK1 ELISA kits, RIPK1 Proteins
Many biological assays use antibodies to detect RIPK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RIPK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RIPK1 antibodies...
Designing an IHC experiment for RIPK1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RIPK1 IHC GuideRIPK1 Infographic by Boster Bio
All RIPK1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00141-3
20μL, 40μL, 100μL, 200μL
Cat # M00141-3
20μL, 40μL, 100μL, 200μL
Anti-RIP RIPK1 Rabbit Monoclonal Antibody
1 Citations
Human
Flow Cytometry, WB
$370
Cat # M00141
100 μl
Cat # M00141
100 μl
RIPK1 Overview
Facts about Receptor-interacting serine/threonine-protein kinase 1.
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Serine-threonine kinase which transduces inflammatory and cell-death signs (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 from the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513).
Phosphorylates DAB2IP in'Ser-728' at a TNF- alpha-dependent fashion, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 through'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which then mediate downstream events such as the activation of genes encoding inflammatory molecules (PubMed:15258597).
Gene Information
| Human | |
|---|---|
| Gene Name: | RIPK1 |
| Uniprot: | Q13546 |
| Entrez: | 8737 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Cell death protein RIP; EC 2.7.11.1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting protein; Receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; RIP; Rip1 kinase; RIP1; RIP-1; RIPFLJ39204; RIPK1; Serine/threonine-protein kinase RIP
Molecular Weight
Mass (kDA):
75.931 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p25.2 |
| Sequence: | 6; NC_000006.12 (3063967..3115187) |
Subcellular Localizations
Cytoplasm. Cell membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Diabetes Mellitus
- Virus Diseases
- Leukemia
- Lymphoma
- Autoimmune Reaction
- Innate Immune Response
- Pancreatitis
- Inflammatory Response
- Malignant Neoplasm Of Lung
- Carcinoma
Interacting Proteins
- ANXA1
- BIRC2
- BIRC3
- CASP10
- CASP8
- CCDC50
- CSNK1A1
- FADD
- IKBKG
- PYCARD
Pathways
- Cell Death
- Necroptosis
- Necrotic Cell Death
- Cell Proliferation
- Autophagy
- Pathogenesis
- Programmed Cell Death
- Cell Activation
- Immune Response
- Cell Cycle
- Inflammatory Response
- Cell Growth
- T Cell Activation
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
Research Areas
- Apoptosis
- Necroptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIPK1
bosterbio.com/bosterbio-gene-info-cards/RIPK1
References
PMID: 8612133 by Hsu H., et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
PMID: 7538908 by Stanger B.Z., et al. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.
5 Publications of Boster RIPK1 Antibodies & ELISA Kits
- PubMed ID: 32135123, Chen H,Tang LJ,Tu H,Zhou YJ,Li NS,Luo XJ,Peng J.Arctiin protects rat heart again...
- PubMed ID: 33675785, Tu H,Zhou YJ,Tang LJ,Xiong XM,Zhang XJ,Ali Sheikh MS,Zhang JJ,Luo XJ,Yuan C,Peng...
- PubMed ID: -, Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Pro...
- PubMed ID: 27464624, Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system ind...
- PubMed ID: 25674205, Chen Yf, Zhao Zq, Wu Zm, Zou Zy, Luo Xj, Li J, Xie C, Liang Y. Int J Clin Exp Pa...
*More publications can be found for each product on its corresponding product page