NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

NAD-dependent protein deacetylase that joins transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, resulting in transcriptional repression.

Deacetylates a broad assortment of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH that's altered by glucose deprivation and metabolic changes associated with caloric restriction.