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CMV MAPK and AKT Pathway Posters downloadable now! Get your technical resources for these important cell signaling maps plus available related products.
BosterBio | Antibodies, ELISA Kits, Detection Kits
November 10, 2017
Dr. Booster
CMV MAPK & AKT

Greetings Earthling,

Using your alphabet soup as a study tool...feasible, but it could be a long lunch break... Click the images below to download pathway maps!

See related pathway antibodies in recommended products below!

alphabet soup
CMV and MAPK Pathway
The binding of cytomegalovirus (CMV), a herpes virus, to a cellular receptor stimulates a series of cellular responses involved in transcriptional regulation, taking advantage of signalling pathways to allow and enhance viral gene replication. One of the major pathways the CMV utilizes is the MAPK pathway. CMV initiates a succession of direct phosphorylation events of small GTPases and protein kinases, and, ultimately, MAPKs (ERK 1/2, p38, JNK). Following activation, MAPKs phosphorylate many cytoplasmic substrates that modulate transcription and gene expression.

In addition to the MAPK pathway, CMV can also activate the Akt and NF-κB signalling pathways.
CMV MAPK Pathway
AKT Signaling Pathway
The Akt/PKB Signaling Pathway is activated by extracellular signals, most commonly a type of growth factor, that phosphorylates PI3K, leading to the production of PIP3. The pleckstrin homology (PH) domain of Akt (Protein Kinase B) possesses a high affinity for PIP3, causing Akt to favorably bind with PIP3. When Akt is completely activated, it is capable of inhibiting or activating up to 100 substrates through phosphorylation, triggering various downstream effects that promote cell survival, growth, and proliferation. The pathway is highly involved in cross-talk with other signalling pathways. Mutations of the pathway may result in higher signalling activity that develop problems with glycogen metabolism and angiogenesis, which are associated with a variety of diseases, such as Type 2 diabetes and cancer. Akt Signaling Pathway

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Anti-MDM2 Antibody (PA1378-1)
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Review : "I've been looking at downstream products of AKT and mTOR transcriptional regulation. I tried several anti-MDM2 antibodies from other companies with either ambiguous or negative results (in Western blots of human cancer cell line lysates) and Boster's is the only one that gave me strong bands at the two expected sizes. I would recommend this product. The bad: Having to resuspend and freeze in tiny aliquots was not my favorite part of using this. The bottom line: I would absolutely buy it again."
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