Anti-Cytochrome P450 2E1 CYP2E1 Antibody

Cytochrome P450 2E1 antibody

Boster Bio Anti-Cytochrome P450 2E1 CYP2E1 Antibody catalog # A00672-2. Tested in WB,ICC applications. This antibody reacts with Human,Mouse,Rat. Cited in 1 publication(s).

Product Info Summary

SKU: A00672-2
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ICC, WB

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Product Name

Anti-Cytochrome P450 2E1 CYP2E1 Antibody

View all Cytochrome P450 2E1 Antibodies

SKU/Catalog Number

A00672-2

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Cytochrome P450 2E1 CYP2E1 Antibody catalog # A00672-2. Tested in WB,ICC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Cytochrome P450 2E1 CYP2E1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00672-2)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human p68 RNA Helicase around the phosphorylation site of Y593.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A00672-2 is reactive to CYP2E1 in Human, Mouse, Rat

Applications

A00672-2 is guaranteed for ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

56.849kDa

Background of Cytochrome P450 2E1

Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and Anti diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements. Anti-Ppar Antibody is useful for research interested in transcription and metabolic pathways.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1000
ICC: 1:50-1:200

Validation Images & Assay Conditions

Gene/Protein Information For CYP2E1 (Source: Uniprot.org, NCBI)

Gene Name

CYP2E1

Full Name

Cytochrome P450 2E1

Weight

56.849kDa

Superfamily

cytochrome P450 family

Alternative Names

4-nitrophenol 2-hydroxylase; CPE1; CYP2Ecytochrome P450 2E1; CYPIIE1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-J; EC 1.14.13.-; EC 1.14.13.n7; EC 1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450C2E; P450-J; xenobiotic monooxygenase CYP2E1 CPE1, CYP2E, P450-J, P450C2E cytochrome P450 family 2 subfamily E member 1 cytochrome P450 2E1|4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450, family 2, subfamily E, polypeptide 1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CYP2E1, check out the CYP2E1 Infographic

CYP2E1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CYP2E1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

A00672-2 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Zhai T,Xu W,Liu Y,Qian K,Xiong Y,Chen Y.Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway.Oxid Med Cell Longev.2020 Nov 27;2020:2313641.doi:10.1155/2020/231
Species: Mouse
A00672-2 usage in article: APP:WB, SAMPLE:LIVER TISSUE, DILUTION:NA

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Order DetailsPrice
A00672-2-100ul

100ul

$405

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