Product Info Summary
SKU: | A01344-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, ICC, WB |
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Product info
Product Name
Anti-Furin Antibody
SKU/Catalog Number
A01344-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Furin Antibody catalog # A01344-1. Tested in WB,IHC,ICC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Furin Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01344-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Cdc25C around the phosphorylation site of T48.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01344-1 is reactive to FURIN in Human, Mouse, Rat
Applications
A01344-1 is guaranteed for IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
86.678kDa
Background of FURIN
The NCOA3 (also known as nuclear receptor coactivator 3 isoform a) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions in a hormone-dependent fashion. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. NCOA3 probably acts via remodeling of chromatin and is involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). NCOA3 is also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. NCOA3 may be associated with diseases such as breast cancer and meningothelial meningioma. Anti-NCOA3 Antibody is useful for researchers interested in cancer research, chromatin binding, transcription coactivator activity, Immunology, and Nuclear Signaling research.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1,000
IHC: 1:50
ICC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of FURIN using Anti-Furin Antibody (A01344-1).
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Furin antibody. Counter stained with hematoxylin.For more protocol information of IHC
Click image to see more details
Figure 1. Western blotting validation for Anti-Furin Antibody A01344-1
Western blot analysis of Furin on different cell lysates using anti-Furin antibody at 1/500 dilution.Positive control:
Lane 1: HepG2
Lane 2: Hela
Lane 3: Hela
Lane 4: MCF-7
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For FURIN (Source: Uniprot.org, NCBI)
Gene Name
FURIN
Full Name
Furin
Weight
86.678kDa
Superfamily
peptidase S8 family
Alternative Names
Dibasic-processing enzyme; EC 3.4.21; EC 3.4.21.75; FUR; FURdibasic processing enzyme; furin (paired basic amino acid cleaving enzyme); Furin; furin, membrane associated receptor protein; PACE; PACEFES upstream region; paired basic amino acid cleaving enzyme (furin, membrane associated receptorprotein); Paired basic amino acid residue-cleaving enzyme; PC; PCSK3; PCSK3furin; proprotein convertase subtilisin/kexin type 3; SPC1 FURIN FUR, PACE, PCSK3, SPC1 furin, paired basic amino acid cleaving enzyme furin|FES upstream region|dibasic processing enzyme|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin 3|proprotein convertase subtilisin/kexin type 3|subtilisin-like proprotein convertase 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FURIN, check out the FURIN Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FURIN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Furin Antibody (A01344-1)
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No publications found for A01344-1
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Customer Reviews
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