Anti-PKA II alpha reg PRKAR2A Antibody

Product Name

Anti-PKA II alpha reg PRKAR2A Antibody

View all PKA R2 Antibodies

SKU/Catalog Number

A03911-1

Size

100μl

Form

Liquid

Description

Boster Bio Anti-PKA II alpha reg PRKAR2A Antibody catalog # A03911-1. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PKA II alpha reg PRKAR2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03911-1)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

9G7F12; 7G6D7

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human Cdc27. at AA rangle: 330-410

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03911-1 is reactive to PRKAR2A in Human

Applications

A03911-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

45.518kDa

Background of PKA R2

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Chong J.A.et.al. (1995)Cell 80:949-957
Schoenherr C.J.et.al.(1995)Science 267:1360-1363
Scholl T.et.al.(1996)J. Immunol. 156:1448-1457
Lunyak V.V.et.al. (2002)Science 298:1747-1752

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of 293 cells using PKA IIalpha reg Polyclonal antibody.

Gene/Protein Information For PRKAR2A (Source: Uniprot.org, NCBI)

Alternative Names

protein kinase, cAMP-dependent, regulatory, type II, alpha; RII-alpha subunit PRKAR2A PKR2, PRKAR2 protein kinase cAMP-dependent type II regulatory subunit alpha cAMP-dependent protein kinase type II-alpha regulatory subunit|cAMP-dependent protein kinase regulatory subunit RII alpha|protein kinase A, RII-alpha subunit|protein kinase, cAMP-dependent, regulatory subunit type II alpha

For more info on PRKAR2A, check out the PRKAR2A Infographic

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In this infographic, you will see the following information for PRKAR2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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