Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody
Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 4(TIMP4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody
See all TIMP-4 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TIMP-4/TIMP4 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. TIMP-4/TIMP4 information: Molecular Weight: 25503 MW; Subcellular Localization: Secreted; Tissue Specificity: Abundant in heart and present at low levels in many other tissues.|
|Cite This Product||Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1078)|
|Similar Products From
|Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody may replace the following items: sc 30076|sc 9374|sc 9375.|
|Reactivity/Species||Human, Mouse, Rat|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4(208-224aa YRGHLPLRKEFVDIVQP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TIMP4 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||7079|
|Species Of This Entry||Human|
|Protein Name||Metalloproteinase inhibitor 4|
|Superfamily||protease inhibitor I35 (TIMP) family|
|Alternative Names||TIMP-4|metalloproteinase inhibitor 4; TIMP metallopeptidase inhibitor 4; TIMP4; TIMP-4; tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4|
|Post Tranlational Modifications||Methylation; Sulphation; Phosphorylation; Oxidation; Dephosphorylation; Acylation|
|Gene Location||3p25.2, on Chromasome 3, gene sequence: NC_000003.12 (12153068..12158912, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TIMP4 (Source: Uniprot.org, NCBI)
|Protein Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.|
|Tissue Specificity||Abundant in heart and present at low levels in many other tissues.|
|Related Diseases||Neoplasms; Malignant Neoplasms; Inflammation; Hypertrophy; Fibrosis; Degenerative Polyarthritis; Cell Invasion; Tissue Adhesions; Neoplasm Metastasis; Neoplasm Invasiveness; Carcinoma; Heart Failure; Malignant Paraganglionic Neoplasm; Myocardial Infarction; Atherosclerosis; Diabetes Mellitus; Tumor Angiogenesis; Rheumatoid Arthritis; Osteoarthritis Of Hip; Arthritis|
|Related Pathways||Pathogenesis; Cell Proliferation; Localization; Cell Adhesion; Proteolysis; Methylation; Angiogenesis; Cell Migration; Gene Silencing; Osteoblast Differentiation; Cellular Homeostasis; Aging; Zymogen Activation; Lung Development; Reverse Transcription; Cell Cycle; Cell Differentiation; Cell Development; Ovulation; Senescence|
|Background||Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. And this gene is mapped to chromosome 3p25. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.|
|Scientific References||PMID: 8939999 by Greene J., et al. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.|
PMID: 9693046 by Olson T.M., et al. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.
Our Boster Quality Guarantee for Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti TIMP4 (PA1078) at 0.5ug/ml
Lane 1: Rat Kidney Tissue Lysate at 50ug
Lane 2: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 25KD
Observed bind size: 25KD
IHC(P): Rat Kidney Tissue
IHC(P): Human Mammary Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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