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Facts about Advanced glycosylation end product-specific receptor.
Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and specifically as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Human | |
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Gene Name: | AGER |
Uniprot: | Q15109 |
Entrez: | 177 |
Belongs to: |
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No superfamily |
advanced glycosylation end product-specific receptor; AGER; RAGE isoform delta; RAGE isoform sRAGE-delta; RAGE; Receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products; SCARJ1
Mass (kDA):
42.803 kDA
Human | |
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Location: | 6p21.32 |
Sequence: | 6; NC_000006.12 (32180968..32184380, complement) |
Endothelial cells.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane; Single-pass type I membrane protein.
The AGER Marker is a great option for cancer research. This marker can measure absorption at about 450nm. This product is compatible with samples ranging from 0.5 milliliters to 1 ml in size. Multichannel pipettes are recommended for larger samples. The company also provides credit for the product to share your results. Read on to learn more about this tool and how it can help you.
Boster Bio makes high-specificity, high sensitivity antibodies that are high-specific, high-sensitivity and high-specific. Their research has been validated against more than 29,000 scientific publications. They can detect biomarkers in the development and neuroscience, as well as inflammation at the level of a picogram. Boster Bio offers their immunological reagents through tebu-bio. Find out more on their products. Customers who have used Boster Bio products have written reviews.
The company also sells a high-performance monoclonal antibodies (boster Bio Anti-His Tag Antibody Pioband) that reacts with all species. The antibody can be stored at -20degC for a year or frozen for up to six months. The company also has an anti-GAPDH blocking protein, which is available at a cost of around $100.
The company's anti-GAPDH ELISA system also allows the use of Boster Bio's bGapDH antibody that is a powerful inhibitor of the c-reactive protein. FDA has approved the new product. It is available in powder and liquid forms. The manufacturer claims that the product is effective in fighting many diseases. For more information about the side effects of Boster Bio Anti-GAPDH Antibody Picoband contact us.
Boster Bio is a global company that is specialized in high-specificity, sensitive antibodies. The company was founded by Steven Xia, Boster Bio has spent more than two decades perfecting their methods and technology. More than 29,000 scientific papers have referenced their antibodies. Each antibody has been tested for flow cytometry, WB, ELISA and IHC.
This antibody recognizes glycophorin A an abundant membrane protein found in red blood cells. The antibody was generated using the antigen GYPA and is useful for immunohistochemistry. Because glycophorin A binds to human RBCs, it is useful in the development and research of erythroid cells. This monoclonal antibody can react with GYPA cell lines and Human cells.
As an anti-GlycophorinA /CD235a monoclonal antibody, Boster Bio is a good choice. It has been flow tested and is unconjugated. This antibody reacts with both Human and Mouse. You can also purchase blocking peptides for use with this antibody. These monoclonal antibody are available in a variety of sizes, and are ideal for research applications.
It is essential to fix the tissue prior to staining. Formalin-fixed tissue should be heated for 45 min at 95C and then cool at RT until it is at 20 minutes. The specific application should determine the correct titration for the antibody. Due to post-translational changes or cleavages, the molecular weight of the protein may differ from the predicted molecular. If stored at -20C, the antibody will remain stable for approximately 24 months.
The anti-Glycophorin/CD235a Monoclonal Antibody is stable in storage at 4°C during short-term usage and -20°C long-term usage. After thawing, anti-CD235ab antibody must be centrifuged in order to ensure maximum recovery. Small amounts of antibody might be trapped within the seal of the vial during storage.
The antibody was examined in a research study to assess the apoptotic capacity of CD235a-nucleated blood cells. The results were used to determine the degree of apoptosis within CD235a+ nucleated blood cells. The protein was expressed in the apoptis related gene messenger RNA.
For qPCR, the anti-GlycophorinA /CD235a monoclonal antibody can be used to detect the presence of CD235a-positive nucleated blood cells. Qiagen synthesized primers for qPCR and Glyceraldehyde 3-Phosphate Dehydrogenase was used as an internal test. The qPCR reaction was performed in a 20-ml volume using a Tiangen super real-fluorescence quantitative kit.
A second study examined the blood of patients suffering from CMS to healthy controls. The CMS group had significantly lower levels of caspase-3, Mcl-1, and Bax than the group of controls. The CMS group also had higher levels of Bcl-2 and Bcl-xl and Bcl-2 than the control group. These results are not statistically significant.
PMID: 1378843 by Neeper M., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
PMID: 7835890 by Sugaya K., et al. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.
*More publications can be found for each product on its corresponding product page