Advanced glycosylation end product-specific receptor (AGER)

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins that accumulate in vascular tissue in aging and at an accelerated rate in diabetes.

Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and specifically as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.