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- Table of Contents
AGER Antibodies
AND AGER ELISA kits, AGER Proteins
Many biological assays use antibodies to detect AGER, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AGER in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AGER antibodies...
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AGER Infographic by Boster Bio
All AGER Products
Product
Figures
Specificity
Applications
Price
Anti-RAGE/AGER Antibody Picoband®
1 Citations 7 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9469
100 μg/vial
Cat # PB9469
100 μg/vial
Human Rage ELISA Kit PicoKine®
6 Citations 7 Q&As
Human
ELISA
$499
Cat # EK0827
96 wells/kit, with removable strips.
Cat # EK0827
96 wells/kit, with removable strips.
Mouse RAGE ELISA Kit PicoKine®
2 Citations 7 Q&As
Mouse
ELISA
$499
Cat # EK0828
96 wells/kit, with removable strips.
Cat # EK0828
96 wells/kit, with removable strips.
Rat RAGE ELISA Kit PicoKine®
5 Citations 8 Q&As
Rat
ELISA
$499
Cat # EK0971
96 wells/kit, with removable strips.
Cat # EK0971
96 wells/kit, with removable strips.
Anti-RAGE/AGER Antibody Picoband®
2 Citations
Human, Mouse, Rat
IHC, IHC-F, WB
$370
Cat # PA1069
100 μg/vial
Cat # PA1069
100 μg/vial
Anti-RAGE AGER Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A03438
100ul
Cat # A03438
100ul
Anti-RAGE/AGER Antibody Picoband®
6 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03438-1
100 μg/vial
Cat # A03438-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M03438-2
100 μg/vial
Cat # M03438-2
100 μg/vial
Human
ELISA
$499
Cat # FEK0827
96 wells/kit, with removable strips.
Cat # FEK0827
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTQ15109-2
5ug,20ug,100ug
Cat # PROTQ15109-2
5ug,20ug,100ug
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M03438-3
100 μg
Cat # M03438-3
100 μg
AGER Overview
Facts about Advanced glycosylation end product-specific receptor.
Advanced glycosylation end product-specific receptor (AGER)
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins that accumulate in vascular tissue in aging and at an accelerated rate in diabetes.
Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and specifically as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Gene Information
| Human | |
|---|---|
| Gene Name: | AGER |
| Uniprot: | Q15109 |
| Entrez: | 177 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
advanced glycosylation end product-specific receptor; AGER; RAGE isoform delta; RAGE isoform sRAGE-delta; RAGE; Receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products; SCARJ1
Molecular Weight
Mass (kDA):
42.803 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (32180968..32184380, complement) |
Tissue Specificity
Endothelial cells.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane; Single-pass type I membrane protein.
Diseases
- Diabetes Mellitus
- Diabetic Nephropathy
- Diabetes Mellitus, Non-insulin-dependent
- Kidney Diseases
- Inflammation
- Malignant Neoplasms
- Atherosclerosis
- Lung Diseases
- Fibrosis
- Chronic Obstructive Airway Disease
- Lung Diseases, Obstructive
- Dysequilibrium Syndrome
- Malignant Neoplasm Of Pancreas
Interacting Proteins
- DIAPH1
- EGFR
- Egfr
- GRB2
- HMGB1
- MAPKAPK5
- NCK1
- PRKCZ
- RHOA
- S100B
Pathways
- Pathogenesis
- Glycosylation
- Localization
- Secretion
- Transport
- Cell Proliferation
- Cell Killing
- Insulin Secretion
- Immune Response
- Autolysis
- Methylation
PTMs
- Glycosylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AGER
bosterbio.com/bosterbio-gene-info-cards/AGER
References
PMID: 1378843 by Neeper M., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
PMID: 7835890 by Sugaya K., et al. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.
20 Publications of Boster AGER Antibodies & ELISA Kits
- PubMed ID: 10.1186/s12933-020-01068-7, Accumulation of advanced glycation end products (AGEs) is associated with the se...
- PubMed ID: 10.1159/000448141, Accumulation of Advanced Glycation End Products Involved in Inflammation and Con...
- PubMed ID: 10.1016/j.jep.2013.11.015, The anti-inflammation effect of Moutan Cortex on advanced glycation end products...
- PubMed ID: 10.1016/j.etap.2020.103577, Protocatechuic acid improves hepatic insulin resistance and restores vascular ox...
- PubMed ID: 10.1016/j.clnu.2021.02.040, Long lasting protective effects of early l-arginine treatment on endothelium in ...
- PubMed ID: 10.1007/s00210-018-1583-4, Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/P...
- PubMed ID: -, Rui Liu,Ying Shu,Wenhui Qi,Weili Rao,Zihan Fu,Zhenxiao Shi,Zhisheng Zhang,"Prote...
- PubMed ID: 33581205, Lian Y,Zhu M,Chen J,Yang B,Lv Q,Wang L,Guo S,Tan X,Li C,Bu W,Ding W,Jia X,Feng L...
- PubMed ID: -, Yudi Zhang,Chunhe Tao,Donglin Du, et al.Astragaloside IV Protects Against Diabet...
- PubMed ID: 33294466, Liang Q,Lin Q,Li Y,Luo W,Huang X,Jiang Y,Qin C,Nong J,Chen X,Sooranna SR,Pinhu L...
- PubMed ID: 18246495 , Radon-induced proteomic profile of lung tissue in rats
- PubMed ID: 27026909, Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by s...
- PubMed ID: 28223765, Li JY, Lu YH, Zhang LW, Zhou PM, Chen T. Ann Dermatol. 2017 Feb;29(1):121-123. d...
- PubMed ID: 28486941, Wang F, He Q, Wang J, Yuan Q, Guo H, Chai L, Wang S, Hu L, Zhang Y. BMC Compleme...
- PubMed ID: 23442498, Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y. Cardiovasc Diabetol. 2013 Feb 26;12:37...
- PubMed ID: 23875897, Liu J, Wang S, Feng L, Ma D, Fu Q, Song Y, Jia X, Ma S. J Med Food. 2013 Jul;16(...
- PubMed ID: 20100543, Wang L, Zhang X, Liu L, Yang R, Cui L, Li M. Neurosci Lett. 2010 Mar 8;471(3):15...
- PubMed ID: 20043889, Wang L, Zhang X, Liu L, Cui L, Yang R, Li M, Du W. Brain Res. 2010 Mar 19;1321:1...
- PubMed ID: 25279006, Xu L, Zang P, Feng B, Qian Q. Diabetol Metab Syndr. 2014 Sep 23;6(1):102. Doi: 1...
- PubMed ID: 23219582, Feng L, Zhu M, Zhang M, Jia X, Cheng X, Ding S, Zhu Q. Int Immunopharmacol. 2013...
*More publications can be found for each product on its corresponding product page