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- Table of Contents
Angiopoietin-2 Antibodies
AND ANGPT2 ELISA kits, Angiopoietin-2 Proteins
Many biological assays use antibodies to detect Angiopoietin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Angiopoietin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Angiopoietin-2 antibodies...
Designing a Western blot for Angiopoietin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ANGPT2 Western Blot GuideANGPT2 Infographic by Boster Bio
All ANGPT2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0657
96 wells/kit, with removable strips.
Cat # EK0657
96 wells/kit, with removable strips.
Anti-Angiopoietin-2/ANGPT2 Antibody Picoband®
10 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00370-2
100 μg/vial
Cat # A00370-2
100 μg/vial
Mouse Angiopoietin-2 ELISA Kit PicoKine®
5 Citations
Mouse
ELISA
$399
Cat # EK0938
96 wells/kit, with removable strips.
Cat # EK0938
96 wells/kit, with removable strips.
Rat Angiopoietin-2 ELISA Kit PicoKine®
4 Citations
Rat
ELISA
$499
Cat # EK1574
96 wells/kit, with removable strips.
Cat # EK1574
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ0657
For 5 plates, 96 wells each
Cat # EZ0657
For 5 plates, 96 wells each
Human
IHC, WB, ELISA (Cap)
$370
Cat # A00370
100 μg/vial
Cat # A00370
100 μg/vial
Anti-Angiopoietin 2 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00370-1
100 μl/vial
Cat # M00370-1
100 μl/vial
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00370-2
100 μg
Cat # M00370-2
100 μg
Human, Mouse, Rat
IHC, WB
$523
Cat # M00370
100 µl
Cat # M00370
100 µl
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00370-4
100 μg
Cat # M00370-4
100 μg
Dog, Human, Mouse, Rabbit, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00370-3
100 μg
Cat # M00370-3
100 μg
Human
$960
Cat # LS000285
20 µg, 100 µg
Cat # LS000285
20 µg, 100 µg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00370-5
100 μg
Cat # M00370-5
100 μg
ANGPT2 Overview
Facts about Angiopoietin-2.
Angiopoietin-2 (ANGPT2)
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 from the absence of ANGPT1.
In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts can induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Gene Information
| Human | |
|---|---|
| Gene Name: | ANGPT2 |
| Uniprot: | O15123 |
| Entrez: | 285 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand
Molecular Weight
Mass (kDA):
56.919 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (6499632..6563420, complement) |
Subcellular Localizations
Secreted.
Diseases
- Tumor Angiogenesis
- Neoplasms
- Malignant Neoplasms
- Pathologic Neovascularization
- Hypoxia
- Inflammation
- Endometrial Polyp
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Brain Neoplasms
- Tissue Adhesions
Interacting Proteins
- TEK
Pathways
- Angiogenesis
- Pathogenesis
- Cell Proliferation
- Cell Migration
- Reverse Transcription
- Localization
- Ovulation
- Endothelial Cell Migration
- Regulation Of Angiogenesis
- Cell Cycle
- Cell Differentiation
- Luteolysis
- Transport
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANGPT2
bosterbio.com/bosterbio-gene-info-cards/ANGPT2
References
PMID: 9204896 by Maisonpierre P.C., et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
PMID: 9927494 by Tanaka S., et al. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.
20 Publications of Boster Angiopoietin-2 Antibodies & ELISA Kits
- PubMed ID: 10.3980/j.issn.2222-3959.2014.04.11, Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angio...
- PubMed ID: 10.3390/ijms222413410, Plasma Lipid Profiling Contributes to Untangle the Complexity of Moyamoya Arteri...
- PubMed ID: 10.1620/tjem.224.221, Exercise Improves Recovery after Ischemic Brain Injury by Inducing the Expressio...
- PubMed ID: 10.1039/D1TB00515D, Construction of AuHQ nano-sensitizer for enhanced radiotherapy efficacy through ...
- PubMed ID: 10.1039/D1BM00834J, An oxidation responsive nano-radiosensitizer increases radiotherapy efficacy by ...
- PubMed ID: 10.1038/s41598-021-91499-3, Whole blood transfusion improves vascular integrity and increases survival in ar...
- PubMed ID: 10.1016/j.neuropharm.2021.108704, Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder...
- PubMed ID: 10.1016/j.neulet.2016.12.066, Expression of angiopoietins in central nervous system hemangioblastomas is assoc...
- PubMed ID: 10.1016/j.leukres.2017.01.017, Simvastatin ameliorates graft-vs-host disease by regulating angiopoietin-1 and a...
- PubMed ID: 10.1016/j.ejogrb.2006.09.018, Expression of heparanase and angiopoietin-2 in patients with endometriosis
- PubMed ID: 10.1007/s11064-015-1684-0, Vascular Endothelial Growth Factor Enhanced the Angiogenesis Response of Human U...
- PubMed ID: 10.1007/s00198-014-2992-y, Local renin-angiotensin system is associated with bone mineral density of glucoc...
- PubMed ID: -, Zhang, P., Peng, J., Ren, Y., Zheng, H., & Yan, H.(2021).Dexmedetomidine protect...
- PubMed ID: 28122283 , Simvastatin ameliorates graft-vs-host disease by regulating angiopoietin-1 and a...
- PubMed ID: 25395699, Benefical Therapeutic Effect of Chinese Herbal Xinji'erkang Formula on Hypertens...
- PubMed ID: 27769178, Autonomic remodeling may be responsible for decreased incidence of aortic dissec...
- PubMed ID: 25161936, Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angio...
- PubMed ID: 29399101, Cai W, Zhang Z, Huang Y, Sun H, Qiu L. Exp Ther Med. 2018 Jan;15(1):924-932. doi...
- PubMed ID: 24040410, Li C, Fan J, Song X, Zhang B, Chen Y, Li C, Mi K, Ma H, Song Y, Tao X, Li G. Plo...
- PubMed ID: 24759991, Bai X, Li X, Tian J, Zhou Z. Plos One. 2014 Apr 23;9(4):E96117. Doi: 10.1371/Jou...
*More publications can be found for each product on its corresponding product page