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Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and reduces its export to the cell surface (total protein levels do not change), likely resulting in defects in class I antigen presentation (PubMed:25356553).
|Sequence:||15; NC_000015.10 (44711492..44718877)|
Secreted. Cell surface. Detected in serum and urine (PubMed:1336137, PubMed:7554280).; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).