Beta-2-microglobulin Antibodies

Beta-2-microglobulin (B2M)

Part of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and reduces its export to the cell surface (total protein levels do not change), likely resulting in defects in class I antigen presentation (PubMed:25356553).

Gene Information

Human
Gene Name:	B2M
Uniprot:	P61769
Entrez:	567

Family

Belongs to:
beta-2-microglobulin family

Alternative Names

B2M; beta 2Microglobulin; beta 2-Microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin

Molecular Weight

Mass (kDA):
13.715 kDA

Genomic Context

Human
Location:	15q21.1
Sequence:	15; NC_000015.10 (44711492..44718877)

Subcellular Localizations

Secreted. Cell surface. Detected in serum and urine (PubMed:1336137, PubMed:7554280).; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).

Diseases

• Malignant Neoplasms
• Neoplasms
• Multiple Myeloma
• Leukemia
• Kidney Diseases
• Malignant Paraganglionic Neoplasm
• Lymphoma
• Carcinoma
• Inflammation
• Kidney Failure, Chronic
• Hiv Infections
• Diabetes Mellitus
• Immunologic Deficiency Syndromes

• Proteinuria Of Undiagnosed Cause
• Infective Disorder
• Amyloidosis
• Autoimmune Reaction
• Melanoma
• Kidney Failure
• Lymphoid Leukemia

Interacting Proteins

• CD1A
• CD1B
• CD244
• HFE
• HLA-A

• PCNA

Pathways

• Excretion
• Reverse Transcription
• Pathogenesis
• Glomerular Filtration
• Immune Response
• Secretion
• Cell Differentiation
• Transport
• Inflammatory Response
• Localization
• Methylation
• Cell Proliferation
• Aging

• Flight
• Cytokine Production
• Cell Growth
• Angiogenesis
• Histone Acetylation
• Dna Methylation
• Regeneration

PTMs

• Methylation
• Acetylation

• Cleavage
• Glycosylation

Research Areas

• Adaptive Immunity
• Cancer
• Diabetes Research
• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/B2M

Best Uses of the B2M Marker

B2M is an endogenous marker that is used to measure the function of the kidney. You may be wondering what are the most effective uses of this marker? This article will cover the clinical applications and diagnostic tests of this marker. It is a useful tool for researchers, patients, and physicians. Learn more. In the meantime, take a look at the following information:

B2M is an endogenous marker for renal function.

B2M levels in blood and urine are crucial indicators of kidney function. B2M is produced by the kidney and is present in greater quantities in patients suffering from certain types of blood cell cancer. B2M is crucial for diagnosing kidney diseases and distinguishing between glomerular or tubular diseases. It isn't a specific disease marker, but it does provide doctors with additional details on the kidney health of a person and their prognosis.

Beta-2 microglobulin levels are elevated in severe infections, both bacterial and viral inflammation, as well as autoimmune diseases. However this test isn't typically used to determine the severity of any disorder of the immune system. Certain medications can trigger an rise in the levels of beta-2 microglobulin in the blood. Some of these include lithium, cyclosporine, aminogltionsicaltubulau/iotesnd physcarboplns np>

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References

PMID: 3312414 by Guessow D., et al. The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

PMID: 16108498 by He X.H., et al. Cloning of human beta-microglobulin gene and its high expression in Escherichia coli.