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- Table of Contents
TNFSF10 Antibodies
AND TNFSF10 ELISA kits, TNFSF10 Proteins
Many biological assays use antibodies to detect TNFSF10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFSF10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFSF10 antibodies...
Designing a Western blot for TNFSF10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TNFSF10 Western Blot GuideTNFSF10 Infographic by Boster Bio
All TNFSF10 Products
Product
Figures
Specificity
Applications
Price
Human TRAIL / CD253 ELISA Kit PicoKine®
8 Citations
Human
ELISA
$499
Cat # EK0532
96 wells/kit, with removable strips.
Cat # EK0532
96 wells/kit, with removable strips.
Anti-TRAIL/TNFSF10 Antibody Picoband®
6 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # A00466-1
100 μg/vial
Cat # A00466-1
100 μg/vial
Human
ELISA
$500
Cat # EZ0532
For 5 plates, 96 wells each
Cat # EZ0532
For 5 plates, 96 wells each
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00469-1
100 μg/vial
Cat # A00469-1
100 μg/vial
SDS-PAGE, Bioactivity
$251
Cat # PROTP50591
Starting from 10ug
Cat # PROTP50591
Starting from 10ug
Mouse
Cell Culture
$77
Cat # PROTP50592-2
5ug,20ug,100ug
Cat # PROTP50592-2
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTP50591-6
5ug,20ug,100ug
Cat # PROTP50591-6
5ug,20ug,100ug
TNFSF10 Overview
Facts about Tumor necrosis factor ligand superfamily member 10.
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and Maybe also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis.Its activity could be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG which can't induce apoptosis. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFSF10 |
| Uniprot: | P50591 |
| Entrez: | 8743 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
Apo-2 ligand; APO2L; Apo-2Ltumor necrosis factor (ligand) family, member 10; APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta; CD253 antigen; CD253; Protein TRAIL; TL2; TNF-related apoptosis-inducing ligand; TNFSF10; TRAIL; TRAILTNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand superfamily member 10
Molecular Weight
Mass (kDA):
32.509 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.31 |
| Sequence: | 3; NC_000003.12 (172505508..172523430, complement) |
Tissue Specificity
Widespread; most predominant in spleen, lung and prostate.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Secreted. Exists both as membrane-bound and soluble form.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Mammary Neoplasms
- Malignant Tumor Of Colon
- Colonic Neoplasms
- Liver Carcinoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- CUL3
- TNFRSF10A
- TNFRSF10B
Pathways
- Cell Death
- Sensitization
- Induction Of Apoptosis
- Pathogenesis
- Cell Cycle
- Cell Growth
- Cell Proliferation
- Immune Response
- Programmed Cell Death
- Secretion
- Cell Killing
- Rna Interference
- Localization
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Dephosphorylation
- Demethylation
- Ubiquitination
- Acetylation
- Reduction
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Death Receptor Signaling Pathway
- Signal Transduction
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFSF10
bosterbio.com/bosterbio-gene-info-cards/TNFSF10
References
PMID: 8777713 by Wiley S.R., et al. Identification and characterization of a new member of the TNF family that induces apoptosis.
PMID: 8663110 by Pitti R.M., et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
13 Publications of Boster TNFSF10 Antibodies & ELISA Kits
- PubMed ID: 10.4161/cbt.8.10.8117, Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene...
- PubMed ID: 10.1186/s13287-019-1194-0, Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suic...
- PubMed ID: 10.1093/jnen/nlz016, Transforming Growth Factor-β Promotes Homing and Therapeutic Efficacy of Human ...
- PubMed ID: 10.1042/BSR20160556, AAV-iRFP labelling of human mesenchymal stem cells for near-infrared fluorescenc...
- PubMed ID: 10.1039/D0NR03698F, Outer membrane vesicles derived from E. coli as novel vehicles for transdermal a...
- PubMed ID: 10.1021/acs.molpharmaceut.6b00964, Conjugation to 10 kDa Linear PEG Extends Serum Half-Life and Preserves the Recep...
- PubMed ID: , Multifunctional cationic polymer decorated and drug intercalated layered silicat...
- PubMed ID: , Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for p...
- PubMed ID: 28377479, AAV-iRFP labelling of human mesenchymal stem cells for near-infrared fluorescenc...
- PubMed ID: 26298772, A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell kil...
- PubMed ID: 29556305, Sun X, Cui M, Wang D, Guo B, Zhang L. Oncol Lett. 2018 Apr;15(4):5744-5750. doi:...
- PubMed ID: 21367858, Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, He Q, Deng M, Liu X, Li G, Li Y, Zh...
- PubMed ID: 24487000, Duan Y, Gu X, Zhu D, Sun W, Chen J, Feng J, Song K, Xu F, He X, He X. Int J Para...
*More publications can be found for each product on its corresponding product page