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Product Info Summary
| SKU: | M01588-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | ELISA, IF, IHC, WB |
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Product info
Product Name
Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody
View all PTH1R/PTHR1 Antibodies
SKU/Catalog Number
M01588-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody catalog # M01588-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01588-1)
Host
Mouse
Contents
Ascitic fluid containing 0.03% sodium azide.
Clonality
Monoclonal
Clone Number
4D2
Isotype
IgG
Immunogen
Purified recombinant fragment of human PTH/PTHrP-R expressed in E. Coli.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01588-1 is reactive to PTH1R in Human
Applications
M01588-1 is guaranteed for ELISA, IF, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
66.361kDa
Background of PTH1R/PTHR1
Bin1 is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, actin organization, programmed cell death, stress responses, and transcriptional control. The first mammalian BAR protein to be discovered, Amphiphysin I (AmphI), was identified in an immunoscreen for proteins associated with the plasma membranes of synaptic neurons, functions in the control of clathrin-dependent synaptic vesicle endocytosis. The mammalian Bin1 gene was first identified in a two hybrid screen for polypeptides that bind to the N-terminal Myc box 1 (MB1) portion of the c-Myc oncoprotein. Bin1 is similar to AmphI in overall structure, with an N-terminal BAR domain and a C-terminal SH3 domain. However, the Bin1 gene is more complex than the AmphI gene, encoding at least seven different splice variants that differ widely in subcellular localization, tissue distribution, and ascribed functions. Alternate splicing of the Bin1 gene results in ten transcript variants encoding different isoform. Bin1 is expressed ubiquitously in mammalian cells. Certain splice variants of Bin1 are expressed in the neurons, muscle cells or tumor cells. Bin1 may act as a cancer suppressor and inhibits malignant cell transformation. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Bin1 has also been implicated in Alzheimer disease and cardiac disease. Defects in Bin1 are the cause of centronuclear myopathy autosomal recessive; also known as autosomal recessive myotubular myopathy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000
Validation Images & Assay Conditions
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Figure 3. Immunofluorescent staining data of PTH1R using Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody (M01588-1).
Immunofluorescence (IF) analysis of SK-BR-3 cells using PTH/PTHrP-R Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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Figure 2. Immunohistochemistry validation of PTH1R using Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody (M01588-1).
Immunohistochemistry (IHC) analysis of paraffin-embedded Human Kidney tissues with DAB staining using PTH/PTHrP-R Monoclonal Antibody.For more protocol information of IHC
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Figure 1. Western blotting validation for Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody M01588-1
Western Blot (WB) analysis using PTH/PTHrP-R Monoclonal Antibody against PTH1R-hIgGFc transfected HEK293 cell lysate.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For PTH1R (Source: Uniprot.org, NCBI)
Gene Name
PTH1R
Full Name
Parathyroid hormone/parathyroid hormone-related peptide receptor
Weight
66.361kDa
Superfamily
G-protein coupled receptor 2 family
Alternative Names
MGC138426; parathyroid hormone 1 receptorMGC138452; parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHRPTHR1parathyroid hormone receptor 1; seven transmembrane helix receptor PTH1R EKNS, PFE, PTHR, PTHR1 parathyroid hormone 1 receptor parathyroid hormone/parathyroid hormone-related peptide receptor|PTH/PTHr receptor|PTH/PTHrP type I receptor|PTH1 receptor|parathyroid hormone receptor 1|parathyroid hormone/parathyroid hormone-related protein receptor|seven transmembrane helix receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PTH1R, check out the PTH1R Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PTH1R: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PTH/PTHrP-R PTH1R Monoclonal Antibody (M01588-1)
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No publications found for M01588-1
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