Amyloid-beta precursor protein (APP)

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.

Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity).