- Table of Contents
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are important integrators of various mitogenenic and antimitogenic signals.
|protein kinase superfamily|
|Sequence:||12; NC_000012.12 (57747727..57752310, complement)|
Cytoplasm. Nucleus. Nucleus membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
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