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- Table of Contents
Prothrombin Antibodies
AND F2 ELISA kits, Prothrombin Proteins
Many biological assays use antibodies to detect Prothrombin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prothrombin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prothrombin antibodies...
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F2 Infographic by Boster Bio
All F2 Products
Product
Figures
Specificity
Applications
Price
Anti-Prothrombin/F2 Antibody Picoband®
2 Citations 16 Q&As
Human
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A00044
100 μg/vial
Cat # A00044
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1668
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1668
1 kit, containing one 96-well plate and all necessary reagents
Human
IHC, WB
$370
Cat # M00044-2
100 μg/vial
Cat # M00044-2
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M00044-3
100 μg/vial
Cat # M00044-3
100 μg/vial
F2 Overview
Facts about Prothrombin.
Prothrombin (F2)
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | F2 |
| Uniprot: | P00734 |
| Entrez: | 2147 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
coagulation factor II (thrombin) receptor-like 2; Coagulation factor II receptor-like 2 (protease-actovated receptor 3); Coagulation factor II receptor-like 2; Coagulation Factor II; F2; PAR-3; PAR3proteinase-activated receptor 3; protease-activated receptor 3; proteinase-activated receptor-3; PT; serine protease; Thrombin receptor-like 2; Thrombin
Molecular Weight
Mass (kDA):
70.037 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (46719201..46739506) |
Tissue Specificity
Expressed by the liver and secreted in plasma.
Subcellular Localizations
Secreted, extracellular space.
Diseases
- Hypertensive Disease
- Pathologic Vasoconstriction
- Neoplasms
- Fibrosis
- Observation Of Neuromuscular Block
- Liver Cirrhosis
- Hemorrhage
- Hepatitis
- Diabetes Mellitus
- Inflammation
- Plant Diseases
- Malignant Neoplasms
- Endometrial Polyp
Interacting Proteins
- THBD
Pathways
- Secretion
- Mating
- Luteolysis
- Ovulation
- Estrus
- Parturition
- Pathogenesis
- Excretion
- Vasoconstriction
- Transport
- Lactation
- Localization
- Vasodilation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Oxidation
- Methylation
- Reduction
- Deglycosylation
- Nitration
- Hydroxylation
- Iodination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F2
bosterbio.com/bosterbio-gene-info-cards/F2
References
PMID: 2825773 by Degen S.J.F., et al. Nucleotide sequence of the gene for human prothrombin.
PMID: 14962227 by Wang W., et al. Prothrombin Shanghai: hypoprothrombinaemia caused by substitution of Gla29 by Gly.
2 Publications of Boster Prothrombin Antibodies & ELISA Kits
- PubMed ID: 10.3389/fonc.2021.621806, Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biolo...
- PubMed ID: 21642433, Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b
*More publications can be found for each product on its corresponding product page