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- Table of Contents
Vinculin Antibodies
AND VCL ELISA kits, Vinculin Proteins
Many biological assays use antibodies to detect Vinculin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Vinculin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Vinculin antibodies...
Designing a Western blot for Vinculin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VCL Western Blot GuideVCL Infographic by Boster Bio
All VCL Products
Product
Figures
Specificity
Applications
Price
Anti-Vinculin/VCL Antibody Picoband®
11 Citations
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01207-1
100 μg/vial
Cat # A01207-1
100 μg/vial
Anti-P2X7/P2RX7 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01208-3
100 μg/vial
Cat # A01208-3
100 μg/vial
Anti-Vinculin VCL Rabbit Monoclonal Antibody
3 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M01207
100 μl
Cat # M01207
100 μl
Anti-Vinculin VCL Antibody
1 Citations
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$335
Cat # A30448
100ul
Cat # A30448
100ul
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01207-3
20μL, 40μL, 100μL, 200μL
Cat # M01207-3
20μL, 40μL, 100μL, 200μL
Chicken, Human, Monkey, Mouse, Rat
IF, IHC-F, ICC, WB
$370
Cat # M01207-4
100 μg/vial
Cat # M01207-4
100 μg/vial
VCL Overview
Facts about Vinculin.
Vinculin (VCL)
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing from the E-cadherin complex.
May also play significant roles in cell morphology and locomotion. .
Gene Information
| Human | |
|---|---|
| Gene Name: | VCL |
| Uniprot: | P18206 |
| Entrez: | 7414 |
Family
| Belongs to: |
|---|
| vinculin/alpha-catenin family |
Alternative Names
CMD1W; CMH15; metavinculin; MVCL; VCL; Vinculin
Molecular Weight
Mass (kDA):
123.799 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.2 |
| Sequence: | 10; NC_000010.11 (73998116..74121363) |
Tissue Specificity
Metavinculin is muscle-specific.
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
Diseases
- Tissue Adhesions
- Male Infertility
- Infertility
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Von Willebrand Disease
- Cardiomyopathies
- Thrombus
- Neoplasm Metastasis
- Headache
- Edema
Interacting Proteins
- ARPC2
- CTNNA1
- TEKT1
Pathways
- Sperm Motility
- Fertilization
- Insemination
- Acrosome Reaction
- Cell Adhesion
- Swimming
- Cell Motility
- Pathogenesis
- Localization
- Secretion
- Platelet Aggregation
- Spermatogenesis
- Cell Proliferation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VCL
bosterbio.com/bosterbio-gene-info-cards/VCL
References
PMID: 2116004 by Weller P.A., et al. Complete sequence of human vinculin and assignment of the gene to chromosome 10.
PMID: 8440716 by Moiseyeva E.P., et al. Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter.
13 Publications of Boster Vinculin Antibodies & ELISA Kits
- PubMed ID: 10.3389/fmolb.2021.725275, Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithe...
- PubMed ID: 10.1016/j.clineuro.2017.04.012, Increased expression of P2X7 receptor in peripheral blood mononuclear cells corr...
- PubMed ID: 10.1016/j.cbi.2016.03.013, Toxicity analysis of various Pluronic F-68-coated carbon nanotubes on mesenchyma...
- PubMed ID: 10.1007/s12010-015-1862-1, Monitoring of TGF-β 1-Induced Human Lung Adenocarcinoma A549 Cells Epithelial-M...
- PubMed ID: 30873379, Wang K,Xing ZH,Jiang QW,Yang Y,Huang JR,Yuan ML,Wei MN,Li Y,Wang ST,Liu K,Shi Z....
- PubMed ID: 32247806, Dong Y,Chen Y,Zhu D,Shi K,Ma C,Zhang W,Rocchi P,Jiang L,Liu X.Self-assembly of a...
- PubMed ID: 29250149, Effects of atorvastatin on porcine aqueous humour outflow and trabecular meshwor...
- PubMed ID: 29312635, Yao Q, An Y, Hou W, Cao YN, Yao MF, Ma NN, Hou L, Zhang H, Liu HJ, Zhang B. Onco...
- PubMed ID: 23444112, Lyu J, Hu Y, Xu X, Zhang H. J Cell Biochem. 2013 Aug;114(8):1744-59. Doi: 10.100...
- PubMed ID: 25820249, Wang H, Wang X, Qu J, Yue Q, Hu Y, Zhang H. J Cell Physiol. 2015 Nov;230(11):272...
- PubMed ID: 24839204, Lyu Z, Wang H, Wang Y, Ding K, Liu H, Yuan L, Shi X, Wang M, Wang Y, Chen H. Nan...
- PubMed ID: 25839041, Shen Z, Lu D, Li Q, Zhang Z, Zhu Y. Biomed Res Int. 2015;2015:871202. Doi: 10.11...
- PubMed ID: 25888745, Su F,, Liu Ss,, Ma Jl, Wang Ds, E Ll, Liu Hc. Stem Cell Res Ther. 2015 Mar 12;6:...
*More publications can be found for each product on its corresponding product page