Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

IL-1 beta/IL-1F2 ELISA kit for Mouse

Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (96 Tests). Quantitate Mouse Il1b in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml. Cited in 538 publication(s). Independently reviewed in 1 review(s).

Product Info Summary

SKU: EK0394
Size: 96 wells/kit, with removable strips.
Reactive Species: Mouse
Application: ELISA
Sample Types: cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

Product Name

Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

View all IL-1 beta/IL-1F2 ELISA kits

SKU/Catalog Number

EK0394

Size

96 wells/kit, with removable strips.

*Question: How many samples can I assay/run in this kit?

Description

Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (96 Tests). Quantitate Mouse Il1b in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml.

Storage & Handling

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Cite This Product

Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (Boster Biological Technology, Pleasanton CA, USA, Catalog # EK0394)

Clonality of Antibodies

See Datasheet for details

Immunogen

Expression system for standard: E.coli; Immunogen sequence: V118-S269

Sensitivity

<1 pg/ml

Assay Range

12.5 pg/ml - 800 pg/ml

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Reactive Species

EK0394 is reactive to Il1b in Mouse samples

Validated Sample Types

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

Application Guarantee

EK0394 is guaranteed for ELISA in Mouse by Boster Guarantee

See how Boster Bio validate our ELISA kits: ELISA Validation Information

Background of IL-1 beta/IL-1F2

Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone1. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells3. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture4. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.

Kit Components

Catalog Number Description Quantity
EK0394-CAP Anti-Mouse Il1b Pre-coated 96-well strip microplate 1
EK0394-ST Mouse Il1b Standard 2 vials, 10 ng/tube
EK0394-DA Mouse Il1b Biotinylated antibody (100x) 100ul
AR1103 Avidin-Biotin-Peroxidase Complex (100x) 100ul
AR1106-1 Sample Diluent 30ml
AR1106-2 Antibody Diluent 12ml
AR1106-3 Avidin-Biotin-Peroxidase Diluent 12ml
AR1104 Color Developing Reagent (TMB) 10ml
AR1105 Stop Solution 10ml
AR1106-5 Wash Buffer (25x) 20ml
PLA-SEA Adhesive plate sealers 4

*The kit components are not available for individual purchase.

Materials Required But Not Included In Kit

  • Microplate Reader capable of reading absorbance at 450nm.
  • Automated plate washer (optional).
  • Pipettes and pipette tips capable of precisely dispensing 0.5 µl through 1 ml volumes of aqueous solutions.
  • Multichannel pipettes are recommended for large amount of samples.
  • Deionized or distilled water.
  • 500ml graduated cylinders.
  • Test tubes for dilution.

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Validation Standard Curve O.D. At 450nm

Concentration (pg/ml)012.52550100200400800
O.D.0.0300.0650.1230.2120.3360.6091.0311.898

Data Example Images

Recommended Sample Dilution Ratios

According to our internal validation assays using this ELISA kit, to detect IL-1 beta/IL-1F2, Dilution ratio of 1:1, concentration in serum is target in serum is below detection limit..

Some articles we found to cite concentrations of IL-1 beta/IL-1F2 in samples: 23025713 (Pubmed IDs).

Intra Assay Consistency & Inter Assay Consistency

We measured random samples of Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® within the same batch/lot to ensure the consistency of the kits' performances. ELISA intra assay consistency is measured using wells from the same plate/assay kit. ELISA inter assay consistency is measured using wells from different plates from the same batch production/lot.

Intra-Assay PrecisionInter-Assay Precision
Sample123123
n161616242424
Mean (pg/ml)3321148336217481
Standard deviation1.7410.3334.292.1914.7535.59
CV (%)5.3%4.9%7.1%6.1%6.8%7.4%

Reproducibility

We ensure reproducibility by testing three samples with differing concentrations of IL-1 beta/IL-1F2 in ELISA kits from four different production batches/lots.

LotsLot 1 (pg/ml)Lot 2 (pg/ml)Lot 3 (pg/ml)Lot 4 (pg/ml)Mean (pg/ml)Standard DeviationCV (%)
Sample 133343132321.113.4%
Sample 22112062032082072.911.4%
Sample 348345243343044921.14.6%
*number of samples for each test n=16.

Gene/Protein Information For Il1b (Source: Uniprot.Org, NCBI)

Uniprot ID

P10749

Gene ID

16176

Gene Name

Il1b

Full Name

Interleukin-1 beta

Weight

30.931kDa

Superfamily

IL-1 family

Alternative Names

catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta Il1b|IL-, IL-1beta, Il-1b|interleukin 1 beta|interleukin-1 beta|IL-1 beta

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Il1b, check out the Il1b Infographic

Il1b infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for Il1b: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

EK0394 has been cited in 538 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264.7 cells

Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis.

Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase

Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment

The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling

Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

The Anti-inflammatory Effects of Heat Shock Protein 72 Involve Inhibition of High-Mobility-Group Box 1 Release and Proinflammatory Function in Macrophages

Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer

Ginsenoside Rg1 improves pathological damages by activating the p21‑p53‑STK pathway in ovary and Bax‑Bcl2 in the uterus in premature ovarian insufficiency mouse models

Exopolysaccharide from Paecilomyces lilacinus modulates macrophage activities through the TLR4/NF‑κB/MAPK pathway

Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways

MicroRNA‑124‑3p attenuates severe community‑acquired pneumonia progression in macrophages by targeting tumor necrosis factor receptor‑associated factor 6

Exclusive enteral nutrition protects against inflammatory bowel disease by inhibiting NF‑κB activation through regulation of the p38/MSK1 pathway

LncRNA uc.48+ is involved in the diabetic immune and inflammatory responses mediated by P2X7 receptor in RAW264.7 macrophages

Programmed cell death‑1/programmed cell death‑ligand 1 inhibitors exert antiapoptosis and antiinflammatory activity in lipopolysaccharide stimulated murine alveolar macrophages

lncRNA uc.48+ regulates immune and inflammatory reactions mediated by the P2X7 receptor in type 2 diabetic mice

Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice

Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury

Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis

Therapeutic effects of four strains of probiotics on experimental colitis in mice

Immune-Enhancing Activity of Aqueous Extracts from Artemisia rupestris L. via MAPK and NF-kB Pathways of TLR4/TLR2 Downstream in Dendritic Cells

Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study

Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson’s Disease May Be Related to its Anti-Inflammatory Action

5-Hydroxymethylfurfural Mitigates Lipopolysaccharide-Stimulated Inflammation via Suppression of MAPK, NF-κB and mTOR Activation in RAW 264.7 Cells

Heterophyllin B Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages by Suppressing the PI3K/Akt Pathways

Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

Anthocyanin Extract from Purple Sweet Potato Exacerbate Mitophagy to Ameliorate Pyroptosis in Klebsiella pneumoniae Infection

Anti-Oxidation and Anti-Inflammatory Potency Evaluation of Ferulic Acid Derivatives Obtained through Virtual Screening

Polysulfide and Hydrogen Sulfide Ameliorate Cisplatin-Induced Nephrotoxicity and Renal Inflammation through Persulfidating STAT3 and IKKβ

In Vitro Immunomodulation of the Polysaccharides from Yam (Dioscorea opposita Thunb.) in Response to a Selenylation of Lower Extent

TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

Hepatoprotective Effect of the Ethanol Extract of Illicium henryi against Acute Liver Injury in Mice Induced by Lipopolysaccharide

Protective Effect of Oxytocin on Ventilator-Induced Lung Injury Through NLRP3-Mediated Pathways

Anthocyanin Protects Cardiac Function and Cardiac Fibroblasts From High-Glucose Induced Inflammation and Myocardial Fibrosis by Inhibiting IL-17

Toxicity and Immunogenicity of a Tardigrade Cytosolic Abundant Heat Soluble Protein in Mice

Qiang Xin 1 Formula Suppresses Excessive Pro-Inflammatory Cytokine Responses and Microglia Activation to Prevent Cognitive Impairment and Emotional Dysfunctions in Experimental Sepsis

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

Deep rTMS Mitigates Behavioral and Neuropathologic Anomalies in Cuprizone-Exposed Mice Through Reducing Microglial Proinflammatory Cytokines

Sleep Deprivation Induces Cognitive Impairment by Increasing Blood-Brain Barrier Permeability via CD44

BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway

Effects of Recombinant Toxoplasma gondii Citrate Synthase I on the Cellular Functions of Murine Macrophages In vitro

TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps via Interaction With SYK in Experimental Subarachnoid Hemorrhage

IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration

Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Curcumin Modulates the Crosstalk Between Macrophages and Bone Mesenchymal Stem Cells to Ameliorate Osteogenesis

Grape seed proanthocyanidin extract supplementation affects exhaustive exercise-induced fatigue in mice

Influence of miR-155 on behaviors of depression mice through regulating Wnt/β-catenin signaling pathway.

Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal Pathway

The atheroprotective roles of heart-protecting musk pills against atherosclerosis development in apolipoprotein E-deficient mice

Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis

Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells

Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes

LL202 protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting MAPK/AP-1 signaling

Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction

The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways

CD36 Participates in PrP106–126-Induced Activation of Microglia

IP3-Mediated Calcium Signaling Is Involved in the Mechanism of Fractalkine-Induced Hyperalgesia Response

Whey Acidic Protein/Four-Disulfide Core Domain 21 Regulate Sepsis Pathogenesis in a Mouse Model and a Macrophage Cell Line via the Stat3/Toll-Like Receptor 4 (TLR4) Signaling Pathway

Astragaloside IV ameliorates cognitive impairment and neuroinflammation in an oligomeric Aβ induced Alzheimers disease mouse model via inhibition of microglial activation and NADPH oxidase expression

Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice

LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation

Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

Involvement of tumor necrosis factor-α in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori

Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice:

Chrysene accelerates the proceeding of chronic obstructive pulmonary disease with the aggravation of inflammation and apoptosis in cigarette smoke exposed mice:

Paraquat-induced inflammatory response of microglia through HSP60/TLR4 signaling:

Honokiol Attenuates Oligomeric Amyloid β1-42-Induced Alzheimer’s Disease in Mice Through Attenuating Mitochondrial Apoptosis and Inhibiting the Nuclear Factor Kappa-B Signaling Pathway

Irisin Rescues Blood-Brain Barrier Permeability following Traumatic Brain Injury and Contributes to the Neuroprotection of Exercise in Traumatic Brain Injury

Propofol Attenuates Hypoxia-Induced Inflammation in BV2 Microglia by Inhibiting Oxidative Stress and NF-κB/Hif-1α Signaling

Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation

Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway

Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M2 Polarization

Quercetin and Quercitrin Attenuates the Inflammatory Response and Oxidative Stress in LPS-Induced RAW264.7 Cells: In Vitro Assessment and a Theoretical Model

Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation

Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice

Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo

Comparison of Inhibitory Effects of Safflower Decoction and Safflower Injection on Protein and mRNA Expressions of iNOS and IL-1β in LPS-Activated RAW264.7 Cells

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet

Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways

Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway

The role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia–reperfusion injury

Taurine Alleviates Schistosoma-Induced Liver Injury by Inhibiting the TXNIP/NLRP3 Inflammasome Signal Pathway and Pyroptosis

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-κB Inhibition

Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Structural characterization and immunoregulatory activity of polysaccharides from Dendrobium officinale leaves

Attenuation of intestinal inflammation of polysaccharides from the seeds of Plantago asiatica L. as affected by ultrasonication

Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid‐induced biochemical alteration in mice

ING4 alleviated lipopolysaccharide‐induced inflammation by regulating the NF‐κB pathway via a direct interaction with SIRT1

Omentin‐1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high‐fat diet‐induced obese mice

Cathepsin B regulates non‐canonical NLRP3 inflammasome pathway by modulating activation of caspase‐11 in Kupffer cells

4‐Sulfonyloxy/alkoxy benzoxazolone derivatives with high anti‐inflammatory activities: Synthesis, biological evaluation, and action mechanism via p38/ERK‐NF‐κB/iNOS pathway

Scorpion venom peptide SVHRSP ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: potential role of Nav1.6 inhibition in microglia

Epigallocatechin‐3‐Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF‐κB and Nrf2/HO‐1 Signalling Pathway Regulation

Chalcone Derivative L6H21 Reduces EtOH + LPS‐Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation

Estrogen reverses nicotine‐induced inflammation in chondrocytes via reducing the degradation of ECM

Mung Bean Protein Hydrolysate Modulates the Immune Response Through NF‐κB Pathway in Lipopolysaccharide‐Stimulated RAW 264.7 Macrophages

MiR‐342 attenuates lipopolysaccharide‐induced acute lung injury via inhibiting MAPK1 expression

GYY4137 exhibits anti‐atherosclerosis effect in apolipoprotein E (−/−) mice via PI3K/Akt and TLR4 signalling

MiR‐30a‐5p ameliorates spinal cord injury‐induced inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling

Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium‐induced colitis in mice

MiR-155 Alleviates Septic Lung Injury by Inducing Autophagy Via Inhibition of Transforming Growth Factor-β-Activated Binding Protein 2

ANGIOGENESIS INHIBITOR ENDOSTATIN PROTECTS MICE WITH SEPSIS FROM MULTIPLE ORGAN DYSFUNCTION SYNDROME

HSF-1 is Involved in Attenuating the Release of Inflammatory Cytokines Induced by LPS Through Regulating Autophagy

Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of estimated glomerular filtration rate and interleukin-1β

Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor–Deficient Mice

Protective Effects of Aqueous Extract of Radix Isatidis on Lipopolysaccharide-Induced Sepsis in C57BL/6J Mice

Polysaccharide from the Seeds of Plantago asiatica L. Protect Against Lipopolysaccharide-Induced Liver Injury

Circular RNA Expression Profiles Following Negative Pressure Wound Therapy in Burn Wounds with Experimental Pseudomonas aeruginosa Infection

Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-κB signaling pathway to attenuate ulcerative colitis

Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway

β-Sitosterol modulates macrophage polarization and attenuates rheumatoid inflammation in mice

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

In vitro immuno-modulatory ability of tryptic caseinate hydrolysate affected by prior caseinate glycation using the Maillard reaction or transglutaminase

Immunomodulatory potentials of the water-soluble yam (Dioscorea opposita Thunb) polysaccharides for the normal and cyclophosphamide-suppressed mice

Tamoxifen Attenuates Lipopolysaccharide/Galactosamine-induced Acute Liver Failure by Antagonizing Hepatic Inflammation and Apoptosis

Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPARγ after experimental subarachnoid hemorrhage

Protective effect of Cordyceps sinensis extract on lipopolysaccharide-induced acute lung injury in mice

Role of genistein on the yield, structure and immunomodulatory activity of Monascus exopolysaccharide

Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet

A Ganoderma atrum polysaccharide alleviated DSS-induced ulcerative colitis by protecting the apoptosis/autophagy-regulated physical barrier and the DC-related immune barrier

Polysaccharides from fermented Asparagus officinalis with Lactobacillus plantarum NCU116 alleviated liver injury via modulation of glutathione homeostasis, bile acid metabolism, and SCFA production

A “sandwich” cell culture platform with NIR-responsive dynamic stiffness to modulate macrophage phenotypes

In vitro and in vivo osteogenesis up-regulated by two-dimensional nanosheets through a macrophage-mediated pathway

Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model

Anti-Alzheimers disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge

Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation

High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage

Effect of Different Titanium Surfaces on Maturation of Murine Bone Marrow-Derived Dendritic Cells

Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infection

Cathelicidin- derived PR39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine

Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice

The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

Intermedin 1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway

Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress

CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways

Hemp (Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice

Lung-Targeting Lysostaphin Microspheres for Methicillin-Resistant Staphylococcus aureus Pneumonia Treatment and Prevention

Discovery of a New Pterocarpan-Type Antineuroinflammatory Compound from Sophora tonkinensis through Suppression of the TLR4/NFκB/MAPK Signaling Pathway with PU.1 as a Potential Target

Multistep Instead of One-Step: A Versatile and Multifunctional Coating Platform for Biocompatible Corrosion Protection

Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure–Activity Relationships to Enhance Bactericidal Efficiency

Near-Infrared-Triggered Dynamic Surface Topography for Sequential Modulation of Macrophage Phenotypes

Integrated Endotoxin Adsorption and Antibacterial Properties of Cationic Polyurethane Foams for Wound Healing

Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after Pulmonary Administration

A Novel Nanomedicine Ameliorates Acute Inflammatory Bowel Disease by Regulating Macrophages and T-Cells

Phenolic C-Glycosides and Aglycones from Marine-Derived Aspergillus sp. and Their Anti-Inflammatory Activities

Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor

l-Arginine Ameliorates Lipopolysaccharide-Induced Intestinal Inflammation through Inhibiting the TLR4/NF-κB and MAPK Pathways and Stimulating β-Defensin Expression in Vivo and in Vitro

Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects

Oral Administration of Bovine Lactoferrin-Derived Lactoferricin (Lfcin) B Could Attenuate Enterohemorrhagic Escherichia coli O157:H7 Induced Intestinal Disease through Improving Intestinal Barrier Function and Microbiota

Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages

Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+

In vivo and in vitro anti-sepsis effects of physcion 8-O-β-glucopyranoside extracted from Rumex japonicus

CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart

Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages

Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5

The inhibitory effect of saPLIγ, a snake sourced PLA2 inhibitor on carrageenan-induced inflammation in mice

Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury

Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways

Toll-like receptor 4 is involved in myocardial damage following paraquat poisoning in mice

VX-765 prevents intestinal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia

A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

FCPR16, a novel phosphodiesterase 4 inhibitor, produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress

Mangiterpenes A–C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene–shikimate–conjugated spirocyclic meroterpenoids from Guignardia mangiferae

Macranthol attenuates lipopolysaccharide-induced depressive-like behaviors by inhibiting neuroinflammation in prefrontal cortex

Anti-inflammatory effects of 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) in vivo and in vitro as a novel NSAIDs lead compound

Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway

Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments

Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer’s disease via activation of adenosine A1 receptor

An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage

Curcumin promotes the spinal cord repair via inhibition of glial scar formation and inflammation

Inhibitory potency of 4- substituted sampangine derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimers disease

Azilsartan, an angiotensin II type 1 receptor blocker, attenuates tert-butyl hydroperoxide-induced endothelial cell injury through inhibition of mitochondrial dysfunction and anti-inflammatory activity

USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells

Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways

IL-33 protects murine viral fulminant hepatitis by targeting coagulation hallmark protein FGL2/fibroleukin expression

A new pleuromutilin candidate with potent antibacterial activity against Pasteurella multocida

Multiple amino acid substitutions involved in enhanced pathogenicity of LPAI H9N2 in mice

Oil-in-water camellia seeds oil nanoemulsions via high pressure microfluidization: Formation and evaluation

Sulforaphane mitigates LPS-induced neuroinflammation through modulation of Cezanne/NF-κB signalling

Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice

Titanium dioxide nanoparticle stimulating pro-inflammatory responses in vitro and in vivo for inhibited cancer metastasis

IGF-1-Expressing Placenta-Derived Mesenchymal Stem Cells Promote Scalding Wound Healing

Neuroprotective Effect of Vaccination with Autoantigen-Pulsed Dendritic Cells After Spinal Cord Injury

Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model

Antinociceptive and anti-inflammatory activities of ethanol-soluble acidic component from Ganoderma atrum by suppressing mannose receptor

Crude polysaccharides from Cistanche deserticola Y.C. Ma as an immunoregulator and an adjuvant for foot-and-mouth disease vaccine

Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice

Ameliorative effect of low molecular weight peptides from the head of red shrimp (Solenocera crassicornis) against cyclophosphamide-induced hepatotoxicity in mice

Indirectly stimulation of DCs by Ganoderma atrum polysaccharide in intestinal-like Caco-2/DCs co-culture model based on RNA-seq

The beneficial effects of dietary grape supplementation on improving cognitive deficits in APP/PS1 double transgenic mice

Ethanol extract of Atractylodis macrocephalae Rhizoma ameliorates insulin resistance and gut microbiota in type 2 diabetic db/db mice

Intervention of probiotic L. reuteri fermented milk as an adjuvant to combat protein energy malnourishment induced gut disturbances in albino mice

Protective effect of Diao Xinxuekang capsule against doxorubicin-induced chronic cardiotoxicity

Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice

Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway

Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway

Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation

Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models

Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis

Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4/NF-κB/MLCK pathway

Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha

Protection from diclofenac-induced liver injury by Yulangsan polysaccharide in a mouse model

Sequential delivery for hepatic fibrosis treatment based on carvedilol loaded star-like nanozyme

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine

The −172 A-to-G variation in ADAM17 gene promoter region affects EGR1/ADAM17 pathway and confers susceptibility to septic mortality with sepsis-3.0 criteria

Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions

miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway

Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/ Nrf-2 crosstalk in mice

The potential protective effects of miR-497 on corneal neovascularization are mediated via macrophage through the IL-6/STAT3/VEGF signaling pathway

Co-expression network analysis identifies innate immune signatures for Albizia julibrissin saponin active fraction-adjuvanted avian influenza vaccine

MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-κB signaling via targeting TRIM8

Inhibition of miR-429 improves neurological recovery of traumatic brain injury mice and attenuates microglial neuroinflammation

Scutellarin suppresses cartilage destruction in osteoarthritis mouse model by inhibiting the NF-κB and PI3K/AKT signaling pathways

Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome

Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis

Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway

Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in mice

STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer’s disease mice via inhibition of ERK1/2 pathway

Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice

Protective effects of polysaccharides from Atractylodes macrocephalae Koidz. against dextran sulfate sodium induced intestinal mucosal injury on mice

An antigen display system of GEM nanoparticles based on affinity peptide ligands

Structure and immunomodulatory activity of a water-soluble α-glucan from Hirsutella sinensis mycelia

Structural characteristics and immunopotentiation activity of two polysaccharides from the petal of Crocus sativus

Novel sampangine derivatives as potent inhibitors of Cu2+-mediated amyloid-β protein aggregation, oxidative stress and inflammation

Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota

Physicochemical characterization and immunomodulatory activity of sulfated Chinese yam polysaccharide

Structure, antioxidant and immunomodulatory activity of a polysaccharide extracted from Sacha inchi seeds

Sulfated modification, characterization, immunomodulatory activities and mechanism of the polysaccharides from Cyclocarya paliurus on dendritic cells

The structural characteristics, antioxidant and hepatoprotection activities of polysaccharides from Chimonanthus nitens Oliv. leaves

Physicochemical, antioxidant properties of giant croaker (Nibea japonica) swim bladders collagen and wound healing evaluation

Comprehensive analysis of lncRNA and mRNA expression profiles in macrophages activated by Actinidia eriantha polysaccharide

Effect of Bacillus sp. DU-106 fermentation on Dendrobium officinale polysaccharide: Structure and immunoregulatory activities

Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation

Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect

Characterizations and hepatoprotective effect of polysaccharides from Mesona blumes against tetrachloride-induced acute liver injury in mice

Extraction, partial characterization and bioactivity of polysaccharides from Senecio scandens Buch.-Ham

Molecular characterization and functional analysis of MyD88 in Chinese soft-shelled turtle Trionyx sinensis

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinsons disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells aga

Effect of Antarctic Krill Phospholipid (KOPL) on High Fat Diet-Induced Obesity in Mice

Structural characterization and immunomodulatory activity of a heterogalactan from Panax ginseng flowers

Structural characterization and immunostimulatory activity of a glucan from natural Cordyceps sinensis

Structure elucidation and immunomodulatory activity of a β-glucan derived from the fruiting bodies of Amillariella mellea

New bioactive secondary metabolites from the Anoectochilus roxburghii endophytic fungus Aspergillus versicolor

Krüppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages

Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model

Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice

Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice

Genetic inactivation of adenosine A2A receptors attenuates acute traumatic brain injury in the mouse cortical impact model

Co-exposures of TiO2 nanoparticles and cadmium ions at non-lethal doses aggravates liver injury in mice with ConA-induced hepatitis

Protective effects of HY1702 on lipopolysaccharide-induced mild acute respiratory distress syndrome in mice

NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-κB and NLRP3 inflammasome

Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4/2 signaling pathway in APP/PS1 mice

rhIL-1Ra reduces hepatocellular apoptosis in mice with acute liver failure mainly by inhibiting the activities of Kupffer cells

The effect of memantine on trinitrobenzene sulfonic acid-induced ulcerative colitis in mice

Stephanthraniline A suppressed CD4+ T cell-mediated immunological hepatitis through impairing PKCθ function

Chronic or high dose acute caffeine treatment protects mice against oleic acid-induced acute lung injury via an adenosine A2A receptor-independent mechanism

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities

Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimers disease

Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency

Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota

Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells

Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis

Neutrophilic granule protein (NGP) attenuates lipopolysaccharide-induced inflammatory responses and enhances phagocytosis of bacteria by macrophages

Propofol participates in gastric mucosal protection through inhibiting the toll-like receptor-4/nuclear factor kappa-B signaling pathway

Myeloid-derived suppressor cells accumulate among myeloid cells contributing to tumor growth in matrix metalloproteinase 12 knockout mice

Biomimetic and responsive nanoparticles loading JQ1 for dual-targeting treatment of vascular restenosis via multiple actions

Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration

The influence of titanium dioxide nanoparticles on their cellular response to macrophage cells

Arabinogalactans from Larix principis-rupprechtii: An investigation into the structure-function contribution of side-chain structures

A novel linear 3-O-methylated galactan isolated from Cantharellus cibarius activates macrophages

Structural characterization and macrophage activation of a hetero-galactan isolated from Flammulina velutipes

Sulfated polysaccharide from Cyclocarya paliurus enhances the immunomodulatory activity of macrophages

Exopolysaccharide from Trichoderma pseudokoningii induces macrophage activation

Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation

Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3

Cotinine ameliorates memory and learning impairment in senescent mice

Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1

Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice

Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner

Inhibition of adenosine monophosphate-activated protein kinase reduces glial cell-mediated inflammation and induces the expression of Cx43 in astroglias after cerebral ischemia

Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1

Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI)

Intraperitoneal supplementation of iron alleviates dextran sodium sulfate-induced colitis by enhancing intestinal barrier function

Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss

CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling

Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β

Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation

Involvement of the TGFβ1- ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy

Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway

Synthesis and biological evaluation of novel 8- substituted sampangine derivatives as potent inhibitor of Zn2+-Aβ complex mediated toxicity, oxidative stress and inflammation

Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury

Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice

Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation

Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome

Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia

Bruceine D elevates Nrf2 activation to restrain Parkinson’s disease in mice through suppressing oxidative stress and inflammatory response

Protective effects of pentadecapeptide derived from Cyclaina sinensis against cyclophosphamide-induced hepatotoxicity

Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway

Cav-1 promotes atherosclerosis by activating JNK-associated signaling

The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response

Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo

Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress

The cystathionine β-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia

Angiopoietin-1 aggravates atherosclerosis by inhibiting cholesterol efflux and promoting inflammatory response

AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice

Knockdown of Long Noncoding RNAs of Maternally Expressed 3 Alleviates Hyperoxia-Induced Lung Injury via Inhibiting Thioredoxin-Interacting Protein–Mediated Pyroptosis by Binding to miR-18a

Macrophage membrane-functionalized nanofibrous mats and their immunomodulatory effects on macrophage polarization

Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-κB inactivation

Mycophenolate mofetil attenuates concanavalin A-induced acute liver injury through modulation of TLR4/NF-κB and Nrf2/HO-1 pathways

A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway

Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway

PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells

Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice

Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment

Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway

MSCs-Derived Extracellular Vesicles Carrying miR-212-5p Alleviate Myocardial Infarction-Induced Cardiac Fibrosis via NLRC5/VEGF/TGF-β1/SMAD Axis

Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury

Alismol, a Sesquiterpenoid Isolated from Vladimiria souliei , Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated Microglia

Effect of the Zn Supplementation on Immuno-Modulatory Activities of Bovine Lactoferrin in the Murine Splenocytes and RAW264.7 Macrophages

Modulatory Effect of the Supplemented Copper Ion on In Vitro Activity of Bovine Lactoferrin to Murine Splenocytes and RAW264.7 Macrophages

Adenosine Promotes the Recovery of Mice from the Cuprizone-Induced Behavioral and Morphological Changes while Effecting on Microglia and Inflammatory Cytokines in the Brain

Hydroxysafflor Yellow A Inhibits Aβ1–42-Induced Neuroinflammation by Modulating the Phenotypic Transformation of Microglia via TREM2/TLR4/NF-κB Pathway in BV-2 Cells

Tolfenamic Acid Attenuates 3-Nitropropionic Acid-Induced Biochemical Alteration in Mice

Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome

A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures

Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo

Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice

Pseudoginsenoside-F11 Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Neutrophil Infiltration and Accelerating Neutrophil Clearance

Evodiamine Inhibits Zymosan-Induced Inflammation In Vitro and In Vivo : Inactivation of NF-κB by Inhibiting IκBα Phosphorylation

The P2X7 Receptor Involved in gp120-Induced Cell Injury in BV2 Microglia

Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway

Human umbilical cord mesenchymal stem cell exosomes alleviate sepsis-associated acute kidney injury via regulating microRNA-146b expression

Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice

Attenuation of the inflammatory response and polarization of macrophages by photobiomodulation

Effect of fermentation times and extracting solvents on the in vitro immune potentials of the soluble extracts of mucor-fermented Mao-tofu

MiR-129-5p prevents depressive-like behaviors by targeting MAPK1 to suppress inflammation

The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression

Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice

Cardioprotective effects of irbesartan in polymicrobial sepsis

Lactobacillus acidophilus Alleviated Salmonella‐Induced Goblet Cells Loss and Colitis by Notch Pathway

Polymeric Nanoparticles Induce NLRP3 Inflammasome Activation and Promote Breast Cancer Metastasis

Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury possibly by regulating Nrf2/HO-1 and TLR4/NF-κB signaling pathways

N‐acetylcysteine attenuates the cuprizone‐induced behavioral changes and oligodendrocyte loss in male C57BL/7 mice via its anti‐inflammation actions

Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss

LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO‐1 pathway

Possible protective effects of CO Q10 against vincristine-induced peripheral neuropathy: Targeting oxidative stress, inflammation, and sarmoptosis

Clopidogrel reduces lipopolysaccharide‐induced inflammation and neutrophil‐platelet aggregates in an experimental endotoxemic model

Three New Indole Diketopiperazine Alkaloids from Aspergillus ochraceus

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

Colloidal Surface Engineering: Growth of Layered Double Hydroxides with Intrinsic Oxidase‐Mimicking Activities to Fight Against Bacterial Infection in Wound Healing

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

Colloidal Surface Engineering: Growth of Layered Double Hydroxides with Intrinsic Oxidase‐Mimicking Activities to Fight Against Bacterial Infection in Wound Healing

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

Colloidal Surface Engineering: Growth of Layered Double Hydroxides with Intrinsic Oxidase‐Mimicking Activities to Fight Against Bacterial Infection in Wound Healing

Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation

Anti-inflammatory effects of three-dimensional graphene foams cultured with microglial cells
Species: Mouse

In vivo study of immunogenicity and kinetic characteristics of a quantum dot-labelled baculovirus
Species: Mouse

Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K/Akt1/mTOR axis
Species: Mouse

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
Species: Mouse

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages
Species: Mouse

CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation
Species: Mouse

Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD
Species: Mouse

Melatonin alleviates cadmium‐induced liver injury by inhibiting the TXNIP‐NLRP3 inflammasome
Species: Mouse

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR‐223/NLRP3 axis
Species: Mouse

Wei,L.,Liu,Y.,Liu,Z.H.I.P.I.N.G.,Mao,Q.I.C.H.A.O.,Shi,N.,& Yang,J.I.A.N.F.E.I.(2021).Inhibitory Effects of Astragalus Polysaccharide on Myocardial Apoptosis Induced by Hypoxia or Reoxygenation in Rats.Indian Journal of Pharmaceutical Sciences,83(3),614-617.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:MYOCARDIAL CELL, DILUTION:NA

Yanyan Yu,Xiangqian Li,Wenpeng Hu,et al.Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation.Authorea.June 22,2021.
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:PLASMA AND BMDMS, DILUTION:NA

Tawfiq,R.A.,Attia,Y.M.,Nassar,N.N.,Hammam,O.A.,Elmazar,M.M.,& Abdallah,D.M.(2021).Insights into the Impact of FXR Activation on Hepatic Autophagy in a Non-alcoholic Steatohepatitis Model.Bulletin of Pharmaceutical Sciences.Assiut,44(1),265-274.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:LIVER TISSUE, DILUTION:NA

Lv M,Xue G,Cheng H,Meng P,Lian X,Hölscher C,Li D. The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinson‘s disease more effectively than the GLP-1 single-receptor agonist NLY01. Brain Behav. 2021 Jun 14. doi: 10.1002/brb3.2231. Epub ahead of print. PMID: 34125470.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

Xingwei Xiang,Xiaoling Zhou,Wenjie Wang,Yufang Zhou,Xuxia Zhou,Shanggui Deng,Bin Zheng,Zhengshun Wen,Effect of Antarctic Krill Phospholipid (KOPL) on High Fat Diet-Induced Obesity in Mice,Food Research International,2021,110456,ISSN 0963-9969,https://doi.org/10.1016/j.foodres.2021.110456.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Zhang W,Li J,Yao H,Li T.Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6.Nanoscale Res Lett.2021 May 21;16(1):89.doi:10.1186/s11671-021-03534-x.PMID:34019224.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BALF, DILUTION:NA

Li D,Weng Y,Wang G,Zhen G.Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal Pathway.Infect Drug Resist.2021;14:1813-1821https://doi.org/10.2147/IDR.S302853
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Wang Y,Gao Y,Huang Y,Pan Y,Yu Y,Zhou Y,Wan SS,Yang YN.The potential protective effects of miR-497 on corneal neovascularization are mediated via macrophage through the IL-6/STAT3/VEGF signaling pathway.Int Immunopharmacol.2021 May 10;96:107745.doi:10.1016/j.intimp.2021. 107745. Epub ahead of print.PMID:33984719.
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:CORNEAL TISSUE, DILUTION:NA

Ren JL,Chen Y,Zhang LS,Zhang YR,Liu SM,Yu YR,Jia MZ,Tang CS,Qi YF,Lu WW.Intermedin1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages.Cell Death Dis.2021 May 1;12(5):436.doi:10.1038/s41419-021-03712-w.PMID:33934111.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:PLASMA, DILUTION:NA

Ai Z,Cheng C,Zhou L,Yin S,Wang L,Liu Y.Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3.Brain Res Bull.2021 Apr 28:S0361-9230(21)00125-8.doi:10.1016/j.brainresbull.2021.04.022.Epub ahead of print.PMID:33932490.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BMSCS AND BRAIN TISSUE, DILUTION:NA

Yilun Luo,Xiaowen Zheng,Peiqi Yuan,Xingyao Ye,Lie Ma,Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes,Bioactive Materials,Volume 6,Issue 11,2021,Pages 4065-4072,ISSN 2452-199X,https://doi.org/10.1016/j.bioactmat.2021.04.018.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BMDM, DILUTION:NA

Duan Y,Zheng H,Li Z,Yao Y,Ding J,Wang X,Nakkala JR,Zhang D,Wang Z,Zuo X,Zheng X,Ling J,Gao C.Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K/Akt1/mTOR axis.Biomaterials.2020 Jul;246:120012.doi:10.1016/j.biomaterials.2020.120012.Epub 2020 Mar 31.PMID:32276198.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:MACROPHAGES, DILUTION:NA

Zhang Y,Wang R,Shi W,Zhihui Z,Wang X,Li C,Zhang S,Zhang P. Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway.J Ethnopharmacol.2021 Apr 1:114063.doi:10. 1016/j.jep.2021.114063.Epub ahead of print.PMID:33813013.
Species: Mouse,Canine
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Zhu Y,Liang H,Liu X,Wu J,Yang C,Wong TM, Kwan KYH,Cheung KMC,Wu S,Yeung KWK.Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration. Sci Adv.2021 Apr 2;7(14):eabf6654.doi:10. 1126/sciadv.abf6654.PMID:33811079.
Species: Mouse,Rat
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Li Y, Wang N, Ma Z, Wang Y, Yuan Y, Zhong Z, Hong Y, Zhao M. Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways. Int J Mol Med. 2021 May;47(5):86. doi: 10.3892/ijmm. 2021.4919. Epub 2021 Mar 24. PMID: 33760150.
Species: Mouse,Rat
EK0394 usage in article: APP:ELISA, SAMPLE:BALF AND RAW264.7 CELL, DILUTION:NA

Li-Bo Jiang, Sheng-Long Ding, Wang Ding, Di-Han Su, Fang-Xue Zhang, Tai-Wei Zhang, Xiao-Fan Yin, Lan Xiao, Yu-Lin Li, Feng-Lai Yuan, Jian Dong, Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration,Chemical Engineering Journal,2021,129323,ISSN 1385-8947,https://doi.org/10.1016/j.cej.2021.129323.
Species: Mouse,Rat
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Shen R, Yin P, Yao H, Chen L, Chang X, Li H, Hou X. Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway. J Inflamm Res. 2021 Mar 5;14:711-718. doi: 10.2147/JIR.S299163. PMID: 33707964; PMCID: PMC7943540.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:J774A.1 CELL, DILUTION:NA

He Y, Peng H, Zhang H, Liu Y, Sun H. Structural characteristics and immunopotentiation activity of two polysaccharides from the petal of Crocus sativus. Int J Biol Macromol. 2021 Mar 4:S0141-8130(21)00523-7. doi: 10.1016/j.ijbiomac.2021.03. 006. Epub ahead of print. PMID: 33676979.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Yin S, Li L, Tao Y, Yu J, Wei S, Liu M and Li J (2021) The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front. Pharmacol. 12:629798. doi: 10.3389/fphar.2021.629798
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:COLON TISSUE, DILUTION:NA

Jie Cheng, Min Chen, Hui-Qi Wan, Xue-Qin Chen, Cheng-Fu Li, Ji-Xiao Zhu, Qing Liu, Guang-Hui Xu, Li-Tao Yi,Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation,Journal of Ethnopharmacology,2021,114046,ISSN 0378-8741,https://doi.org/10.1016/j.jep.2021.114046.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS TISSUE, DILUTION:NA

Liu Hui,Zhou Chuankun,Qi Dahu,Gao Yutong,Zhu Meipeng,Tao Tenghui,Sun Xuying,Xiao Jun,Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.Frontiers in Cell and Developmental Biology,VOLUME=9,YEAR=2021, PAGES=544, URL=https://www.frontiersin.org/article/10.3389/fcell.2021.640867. DOI=10.3389/fcell.2021.640867,ISSN=2296-634X
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Li ZT,Liu H,Zhang WQ.NLRC3 alleviates hypoxia/reoxygenation induced inflammation in RAW264.7 cells by inhibiting K63-linked ubiquitination of TRAF6.Hepatobiliary Pancreat Dis Int.2020 Oct;19(5):455-460.doi:10.1016/j.hbpd.2020.04.003.Epub 2020 May 3.PMID:3
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Fu DN,Wang Y,Yu LJ, Liu MJ,Zhen D.Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5.Exp Cell Res.2021 Feb 23: 112519.doi:10.1016/j.yexcr.2021.11251
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Natarajan Bhaskaran,Sangeetha Jayaraman,Cheriese Quigley,Prerna Mamileti,Mahmoud Ghannoum,Aaron Weinberg,Jason Thuener,Quintin Pan,Pushpa Pandiyan bioRxiv 2021.02.15.431361;doi: https://doi.org/10.1101/2021.02.15.431361
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:TONGUE TISSUE, DILUTION:NA

Zhang G,Li T,Chang X,Xing J.Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis.Neurochem Res.2021 Feb 20.doi:10.1007/s11064-021-03265-6.Epub ahead of print.PMID:33609254.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BV2 CELL, DILUTION:NA

Liu Y,Qi Y.Vildagliptin, a CD26/DPP4 inhibitor, ameliorates bleomycin-induced pulmonary fibrosis via regulating the extracellular matrix.Int Immunopharmacol.2020 Oct;87:106774.doi:10.1016/j.intimp.2020.106774.Epub 2020 Jul 27. PMID:32731178.
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:PLASMA AND LUNG TISSUE, DILUTION:NA

Liu H,Hu X,Jiang R,Cai J,Lin Q,Fan Z,Zhao P,Wang S,Zou C,Du W,Dong Z,Liu Y.CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice.Inflammation.2021 Feb 2.doi:10.1007/s10753-021-01420-3.Epub ahead of print.PMID:33
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:MICROGLIAL CELL AND BRAIN TISSUE, DILUTION:NA

Zou XY,Xie RR,Li W,Su CL,Chen YS,Tang H.Novel sampangine derivatives as potent inhibitors of Cu2+-mediated amyloid-β protein aggregation, oxidative stress and inflammation.Int J Biol Macromol.2021 Jan 18:S0141-8130(21)00123-9.doi:10.1016/j.ijbiomac.2021.0
Species: Mouse,Worms
EK0394 usage in article: APP:ELISA, SAMPLE:BV2 CELL, DILUTION:NA

Liu Y,Feng M,Cai J,Li S,Dai X,Shan G,Wu S.Repurposing bortezomib for choroidal neovascularization treatment via antagonizing VEGF-A and PDGF-D mediated signaling.Exp Eye Res.2021 Jan 18;204:108446.doi:10.1016/j.exer.2021.108446.Epub ahead of print.PMID:33
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RPE TISSUE, DILUTION:NA

Sharma D,Arora S,Banerjee A,Singh J.Improved insulin sensitivity in obese-diabetic mice via chitosan Nanomicelles mediated silencing of pro-inflammatory Adipocytokines.Nanomedicine.2021 Jan 15:102357.doi:10.1016/j.nano.2020.102357.Epub ahead of print. PMI
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Liu Y,Wang T,Si B,Du H,Liu Y,Waqas A,Huang S,Zhao G,Chen S,Xu A.Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota. EcotoxicolEnviron Saf.2021 Jan 8;210:111903.doi:10.1016/j.eco
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:COLON TISSUE, DILUTION:NA

Zheng Q,Zhang J,Zuo X,Sun J,Liang Z,Hu X,Wang Z,Li K,Song J,Ding T,Shen X,Ma Y,Li P.Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:MACROPHAGES, DILUTION:NA

Li Y,Song W,Tong Y,Zhang X,Zhao J,Gao X,Yong J,Wang H.Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis.J Neuroinflammation.2021 Jan 5;18(1):1.doi:10.1186/s12974-020-02040-8.PMID:33402173;PMCID:PMC7
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM AND HIPPOCAMPUS TISSUE, DILUTION:NA

Chen X,He Y,Zhu Y,Du J,Sun H.linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses.Cell Rep.2021 Jan 5;34(1):108584.doi:10.1016/j.celrep.2020.108584.PMID:33406422.
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Wang W,Xu RL,He P,Chen R.MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.J Inflamm (Lond).2021 Feb 8;18(1):8.doi:10.1186/s12950-021-00271-x
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL, DILUTION:NA

Long-Wei Li,Xiao-Yi Chen,Lan-Cong Liu,Yi Yang,You-Jiao Wu,Gang Chen,Zhi-Feng Zhang,Pei Luo,Oil-in-water camellia seeds oil nanoemulsions via high pressure microfluidization: Formation and evaluation,LWT,2020, 110815,ISSN 0023-6438,https://doi.org/10.1016/
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Mingyue Shen,Xianxiang Chen,Lixin Huang,Qiang Yu,Yi Chen,Jianhua Xie,Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice,Journal of Functional Foods,Volume 76,2021,104321,ISSN 1756-4646,h
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELLS, DILUTION:NA

J. Med.Chem. 2021, 64, 1, 768–781 Publication Date:December 1, 2020
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Xinxin Zhang,Yating Qin,Xiaoning Wan et al. Rosuvastatin Inhibits Atherosclerosis Development by Improving Lipid Accumulation and Polarization Conversion of Macrophages via Regulating Autophagy, 19 November 2020,PREPRINT (Version 1) available at Research
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Wang X,Tong Y,Zhang J,Khan N,Zhang K,Bai H,Zhang Q,Chen Y.Neuroinflammation changes with periodontal inflammation status during periodontitis in wild-type mice.Oral Dis.2020 Aug 20.doi:10.1111/odi.13618.Epub ahead of print.PMID:32815656.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPI, DILUTION:NA

Yang L,Liu G,Fu L,Zhong W,Li X,Pan Q. DNA repair enzyme OGG1 promotes alveolar progenitor cell renewal and relieves PM2.5-induced lung injury and fibrosis. Ecotoxicol Environ Saf.2020 Dec 1;205:111283.doi: 10.1016/j.ecoenv.2020.111283. Epub 2020 Sep 22.PM
Species: Human,Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BALF, DILUTION:NA

Kong Y,Peng Q,Lv N,Yuan J,Deng Z,Liang X,Chen S,Wang L.Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer‘s disease via activation of adenosine A1 receptor. Neurosci Lett.2020 Jun 21;730:135016.doi:10.1016/j.neulet.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS AND CORTEX, DILUTION:NA

Gao Y,Zhou X,Zhou Y,Zhang W,Zhao L.Chrysene accelerates the proceeding of chronic obstructive pulmonary disease with the aggravation of inflammation and apoptosis in cigarette smoke exposed mice.Hum Exp Toxicol.2020 Dec 20:960327120979343.doi:10. 1177/096
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:LUNG TISSUE, DILUTION:NA

Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R. Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation.J Immunol Res.2020 Aug 27;2020:8263598.doi:10.1155/2020/ 8263598.PMID
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:PODOCYTES, DILUTION:NA

Zhou Z,Hou J,Mo Y,Ren M,Yang G,Qu Z,Hu Y.Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4/2 signaling pathway in APP/PS1 mice.Eur J Pharmacol.2020 Feb 15;869:1
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:CORTEX AND HIPPOCAMPUS TISSUE, DILUTION:NA

Li Y,Zheng D,Shen D,Zhang X,Zhao X,Liao H.Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M2 Polarization.J Immunol Res.2020
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:PODOCYTES, DILUTION:NA

Zhu J, Yang LK, Chen WL, Lin W, Wang YH, Chen T. Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits. Front Pharmacol. 2019 Apr 2;10:325. doi: 1
Species: Rabbit
EK0394 usage in article: APP:ELISA, SAMPLE:SPINAL CORD, DILUTION:NA

He L,Wang X,Cheng D,Xiong Z,Liu X. Ginsenoside Rg1 improves pathological damages by activating the p21‑p53‑STK pathway in ovary and Bax‑Bcl2 in the uterus in premature ovarian insufficiency mouse models. Mol Med Rep.2021 Jan;23(1):37.doi:10.3892/mmr.2020.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:OVARY AND UTERUS TISSUE, DILUTION :NA

Zhao S, Fan Z, Hu J, Zhu Y, Lin C, Shen T, Li Z, Li K, Liu Z, Chen Y, Zhang B. The differential effects of isoflurane and sevoflurane on neonatal mice. Sci Rep. 2020 Nov 9;10(1):19345. doi: 10.1038/s41598-020-76147-6. PMID: 33168900; PMCID: PMC7652873.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

Dai Z,Chen XY,An LY,Li CC,Zhao N,Yang F,You ST,Hou CZ,Li K,Jiang C,You QD,Di B,Xu LL. Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis. J Med Chem. 2020 Dec 17.doi: 10.1021/acs.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:THP-M CELL AND SERUM, DILUTION:NA

Zhang Z,Jiang S,Tian H,Zeng Y,He K,Lin L,Yu F. Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models. J Ethnopharmacol. 2020 Dec 15:113698.doi:10.1016/j.je
Species: Mouse, Nymphaea hybrida
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELLS, DILUTION:NA

Zheng B, Ying M, Xie J, Chen Y, Wang Y, Ding X, Hong J, Liao W, Yu Q. A Ganoderma atrum polysaccharide alleviated DSS-induced ulcerative colitis by protecting the apoptosis/autophagy-regulated physical barrier and the DC-related immune barrier. Food Funct
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:COLON TISSUE, DILUTION:NA

Zhou Q, Guo D, Li X, Wang Y, Ye X, Xue S, Wang X. Anti-inflammatory effects of vinpocetine in LPS-stimulated microglia via activation of AMPK. An Acad Bras Cienc. 2020 Nov 20;92(4):e20200241. doi: 10.1590/0001-3765202020200241. PMID: 33237143.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BV2 MICROGLIA, DILUTION:NA

Sun HJ, Xiong SP, Cao X, Cao L, Zhu MY, Wu ZY, Bian JS. Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3. Redox Biol. 2020 Nov 25;38:101813. doi: 10.1016/j.redo
Species: Mouse, Human
EK0394 usage in article: APP:ELISA, SAMPLE:RENAL TISSUE, DILUTION:NA

Du Y, Liu G, Zhao L, Yao R. Protective Effect of miR-204 on Doxorubicin-Induced Cardiomyocyte Injury via HMGB1. Oxid Med Cell Longev. 2020 Nov 19;2020:8819771. doi: 10.1155/2020/8819771. PMID: 33274007; PMCID: PMC7695502.
Species: Mouse, Rat
EK0394 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Huang Y, Tang J, Cai Z, Zhou K, Chang L, Bai Y, Ma Y. Prevotella Induces the Production of Th17 Cells in the Colon of Mice. J Immunol Res. 2020 Nov 1;2020:9607328. doi: 10.1155/2020/9607328. PMID: 33204736; PMCID: PMC7657696.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BMDC CELLS, DILUTION:NA

Cui L, Guan X, Ding W, Luo Y, Wang W, Bu W, Song J, Tan X, Sun E, Ning Q, Liu G, Jia X, Feng L. Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMLE:COLON EXTRACTS, DILUTION:NA

Wu X, Lin L, Wu H. Ferulic acid alleviates lipopolysaccharide-induced acute lung injury through inhibiting TLR4/NF-κB signaling pathway. J Biochem Mol Toxicol. 2020 Nov 2:e22664. doi: 10.1002/jbt.22664. Epub ahead of print. PMID: 33140555.
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:BALF, DILUTION:NA

Liu H,Fan J,Zhang W,Chen Q,Zhang Y,Wu Z.OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6.Biochem Biophys Res Commun.2020 Mar 19;523(4):924-930. doi:10.1016/j.bbrc.2019.12.114.Epub 2020 Jan 19.PMID:
Species: Mouse
EK0394 usage in article: APP:ELISA, SAMPLE:RAW264.7 CELL AND SERUM, DILUTION:NA

Lu, Mengchen, et al. "A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions." Redox Biology (2020): 101565.

Activation of the p38 MAPK/NF-%u03BAB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cells

Trimetazidine attenuates cardiac dysfunction in endotoxemia and sepsis by promoting neutrophil migration

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling %u2026

Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis

Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-%u03BAB and IL-1%u03B2 %u2026

Protection of SAL B with H9C2 cells

Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor%u2013Deficient Mice

HoxA13 Stimulates Myometrial Cells to Secrete IL-1%u03B2 and Enhance the Expression of Contraction-Associated Proteins

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Exclusive enteral nutrition protects against inflammatory bowel disease by inhibiting NF%u2011%u03BAB activation through regulation of the p38/MSK1 pathway

Nobiletin attenuates lipopolysaccharide/D%u2011galactosamine%u2011induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF%u2011%u03BAB %u2026

Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate sodium-induced ulcerative colitis in mice.

Death-associated protein kinase 1 mediates interleukin-1? production through regulating inlfammasome activation in Bv2 microglial cells and mice

Grape seed proanthocyanidin extract supplementation affects exhaustive exercise-induced fatigue in mice

Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer

Toxoplasma gondii excretory/secretory antigens (TgESAs) suppress pro-inflammatory cytokine secretion by inhibiting TLR-induced NF-?B activation in LPS-stimulated murine macrophages

Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury

Effects of Recombinant Toxoplasma gondii Citrate Synthase I on the Cellular Functions of Murine Macrophages In vitro

Evaluation of the chemical composition, antioxidant and anti-inflammatory activities of distillate and residue fractions of sweet basil essential oil

Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-?B and JNK/p38 MAPK Signal Pathways

Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells

High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage

Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet

Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice

Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-?B Signaling Pathway

Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-?B and p38 MAPK

Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes

NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-?B Signaling Pathway

LL202 protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting MAPK/AP-1 signaling

Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

Synergistic Effect of Compounds from a Chinese Herb: Compatibility and Dose Optimization of Compounds from N-Butanol Extract of Ipomoea stolonifera

PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice

Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-?-catenin axis

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase

Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

Effect of Gui Zhi decoction on enteric mucosal immune in mice with collagen-induced arthritis

Li J, Diao B, Guo S, Huang X, Yang C, Feng Z, Yan W, Ning Q, Zheng L, Chen Y, Wu Y. Nat Commun. 2017 Nov 6;8(1):1322. doi: 10.1038/s41467-017-01327-4. VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate met...

Jia YP, Wang K, Zhang ZJ, Tong YN, Han D, Hu CY, Li Q, Xiang Y, Mao XH, Tang B. PLoS One. 2017 Oct 9;12(10):e0186179. doi: 10.1371/journal.pone.0186179. eCollection 2017. TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation ca...

Liu X, Zhang X, Ding Y, Zhou W, Tao L, Lu P, Wang Y, Hu R. Antioxid Redox Signal. 2017 Jan 1;26(1):28-43. doi: 10.1089/ars.2015.6615. Epub 2016 Aug 9. Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibitin...

Chen S, He Y, Hu Z, Lu S, Yin X, Ma X, Lv C, Jin G. J Histochem Cytochem. 2017 Apr;65(4):241-249. doi: 10.1369/0022155417692536. Epub 2017 Feb 7. Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis

Zhou W, Liu X, Zhang X, Tang J, Li Z, Wang Q, Hu R. Oncotarget. 2017 Jul 22;8(35):58903-58917. doi: 10.18632/oncotarget.19440. eCollection 2017 Aug 29. Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome

Lu Y, Zhang XS, Zhang ZH, Zhou XM, Gao YY, Liu GJ, Wang H, Wu LY, Li W, Hang CH. J Neuroinflammation. 2018 Mar 19;15(1):87. doi: 10.1186/s12974-018-1118-4. Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarach...

Zhang Y, Feng J, Cui J, Yang G, Zhu X. Mol Med Rep. 2018 Apr;17(4):5805-5813. doi: 10.3892/mmr.2018.8609. Epub 2018 Feb 15. Pre-B cell leukemia transcription factor 3 induces inflammatory responses in human umbilical vein endothelial cells and mur...

Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B. Cell Death Dis. 2018 Feb 7;9(2):171. doi: 10.1038/s41419-017-0257-3. Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell py...

Zhang BC, Li Z, Xu W, Xiang CH, Ma YF Am J Transl Res. 2018 Jan 15;10(1):265-273. eCollection 2018. Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264.7 cells

Du, J., Chen, X., Wang, C., & Sun, H. (2017). Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha. Journal of Ethnopharmacology. Advance online publication. doi: 1...

Wang, Q., Dong, X., Wang, Y., Liu, M., Sun, A., Li, N.,..., & Li, X. (2017). Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult...

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1 Reviews For Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

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Easy-to-Use Cytokine Quantification--Divya Sharma, NDSU, Pharmaceutical Sciences, Graduate Student

Excellent

Source: Biocompare.com

Application ELISA
Sample Cell culture media
Detection --

"The ELISA kit from Boster Bio was easy to use and gave reproducible results each time. The protocol was well explained and each thing was paid good attention. They also provided tools for data analysis (myassay.com) which I really found useful. The standard plot was as suggested. The cytokines analyzed were comparable to literature reported. Will definitely purchase again. Excellent product." (Customer’s Tip: "Stick to the protocol.")

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19 Customer Q&As for Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

Question

Q: how long can samples (cell cultures, serum, and plasma) be stored and still be stable for analysis IL-1 beta using the EK0394 Mouse IL-1 beta Picokine® ELISA Kit?

T. Li

Verified customer

Asked: 2020-11-21

Answer

A: Boster Bio does not evaluate sample stability. Variations in sample collection, processing, and storage may alter the stabilityof samples. It is recommend to assay sample on priority basis collection when possible, or aliquot into single use volumes and store samples frozen. limit repetitive freeze-thaw cycles with the stored samples to avoid protein degradation.

Boster Scientific Support

Answered: 2020-11-21

Question

What form of the IL1-B is detected by EK0394? Will it detect both forms: before and after cleavage?

Verified customer

Asked: 2020-10-21

Answer

The Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394) detects both forms: before and after cleavage.

Boster Scientific Support

Answered: 2020-10-22

Question

Q: can you tell me how to prepare cell lysates prepared for use in Picokine® ELISA kits?

Verified Customer

Verified customer

Asked: 2020-07-15

Answer

A: in those Picokine® ELISAs where cell or tissue lysate is a validated sample type, sample preparation instructions for lysate are included in the product insert. Components in lysate and lysis buffer may affect immunoreactivity, so if lysate is not a validated sample type, care must be taken in sample preparation and validation.

Boster Scientific Support

Answered: 2020-07-15

Question

Q: how much samples can be assayed in a Picokine® ELISA Kit?

Verified Customer

Verified customer

Asked: 2020-06-24

Answer

A: The Picokine® ELISA Kits will generally run a 7-point standard curve, non-specific binding wells, and 39 samples in duplicate. this may might differ by kit so please refer to each datasheet for details.

Boster Scientific Support

Answered: 2020-06-24

Question

Q: Are Boster Bio recombinant proteins and antibodies sterile?

Verified Customer

Verified customer

Asked: 2020-06-17

Answer

A: although the vials are bottled using aseptic techniques, heat-treated vials, and sterile stock solutions, they are not considered or guaranteed to be sterile. If sterile material is required for an experiment, the material can be filtered through a 0.2 micron filter designed for use with biological fluids.

Boster Scientific Support

Answered: 2020-06-17

Question

Does this Mouse IL-1 Beta ELISA Kit PicoKine detect both pro and mature forms of IL1 beta?

Verified Customer

Verified customer

Asked: 2020-04-03

Answer

The Mouse IL-1 Beta ELISA Kit PicoKine detects only the mature form of IL-1 beta. Detection of the pro form has not been tested.

Boster Scientific Support

Answered: 2020-04-03

Question

Our customer wonder about the "Customer Q&As" of the Mouse IL-1 Beta PicoKine

Verified Customer

Verified customer

Asked: 2019-10-21

Answer

Please see the following answers for the questions. 1) Should we need to centrifuge the homogenates, collect the supernatant for detection? Please centrifuge the homogenates and collect the supernatant for detection. 2) How much of ABC and TMB should be used to mixed with the sample ? Do you have any suggestion ? Please follow the protocol specified on the kit insert without adding the detection antibody. Add 100

Boster Scientific Support

Answered: 2019-10-21

Question

Is there a need to centrifuge the homogenates in collecting supernatant for detection using EK0394 kit?

Verified customer

Asked: 2019-09-06

Answer

For the Mouse IL-1 Beta ELISA Kit PicoKine EK0394, centrifuge the homogenates and collect the supernatant for detection.

Boster Scientific Support

Answered: 2019-09-08

Question

How much of ABC and TMB should be used to mix with the sample using EK0394 kit?

Verified customer

Asked: 2019-09-06

Answer

For the Mouse IL-1 Beta ELISA Kit PicoKine EK0394, add 100 µl of the prepared 1x Avidin-Biotin-Peroxidase Complex and 90 µl of TMB Color Developing Reagent into each well.

Boster Scientific Support

Answered: 2019-09-08

Question

I would like to ask if whether this antibody Mouse IL-1 Beta ELISA Kit PicoKine is suitable for heparin or EDTA and it would not affect the ELISA procedure.

Verified Customer

Verified customer

Asked: 2019-08-23

Answer

The product Mouse IL-1 Beta ELISA Kit PicoKine is compatible with EDTA or heparin.

Boster Scientific Support

Answered: 2019-08-23

Question

Can you confirm if the EK0394 is compatible with ELISA microplate washers?

Verified customer

Asked: 2019-05-30

Answer

Our ELISA kits should be compatible for all ELISA microplate washers as long as it supports a 96 well plate.

Boster Scientific Support

Answered: 2019-05-30

Question

Can the sample diluent buffer, ABC diluent buffer and antibody diluent buffer be used interchangeably between the kit?

Verified customer

Asked: 2019-05-28

Answer

For the Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394), the sample diluent buffer, ABC diluent buffer and antibody diluent buffer can be used interchangeably between the kit. However, the sample diluent buffer can only be used to dilute standards and samples, ABC diluent buffer is used to dilute ABC only and antibody diluent buffer is used to dilute antibody only.

Boster Scientific Support

Answered: 2019-05-29

Question

My plasma samples have been somewhat hemolyzed. Does plasma hemolysis have any effect on ELISA results? Keyword: application, protocol, troubleshooting

Verified Customer

Verified customer

Asked: 2019-03-28

Answer

There will be some unspecific staining in hemolysis samples and make the result inaccurate. We suggest you collect plasma samples again, hemolysis samples are not recommended to use.

Boster Scientific Support

Answered: 2019-03-28

Question

Q: Can IL-1 beta ELISA Kits be used with tissue homogenates (or other non-validated sample types)?

Verified Customer

Verified customer

Asked: 2019-03-17

Answer

A: Unfortunately, Boster Bio has not routinely validated tissue homogenates as a sample type for ELISA kits. This does not mean that ELISA kits are not suitable for other sample types than we have tested: it means further investigation is a must. One will need to perform a spike and recovery study to determine if an unvalidated sample type will work with a particular kit. To perform a spike and recovery experiment, one should divide a sample into two aliquots. In one of the aliquots, the user should spike in a known amount of the kit standard. a dilution series is performed comparing the spiked versus the unspiked sample. Generally, samples with expected recovery and linearity between 80-120% are considered acceptable. This method can be used to validate any sample type that has not been assessd by Boster Bio. for a more detailed spike and recovery protocol, please contact technical support.
Note: acceptable ranges should be determined individually by each laboratory. Additionally, technical support can help determine if a buffer component is not compatible with a given ELISA kit. please view the Citations tab on the product webpage for peer-reviewed papers utilizing a wide range of sample types. We also have an innovator's reward program where if the user validates our ELISA kits in applications or samples previously not validated by Boster Bio or other users, and share such information with us by submit a review, we will reward the user's efforts with a free antibody or ELISA kit from our catalog. Biocompare.com will also give $20 Amazon giftcard as an additional reward, if the review is submitted there as well.

Boster Scientific Support

Answered: 2019-03-17

Question

Q: is there any online tool I can use to streamline the data analysis for my ELISA results?

M. Evans

Verified customer

Asked: 2018-11-18