Anti-DNM1L Antibody (C-term)

Product Name

Anti-DNM1L Antibody (C-term)

View all DRP1 Antibodies

SKU/Catalog Number

M00556

Size

80 µl

Description

Boster Bio Anti-DNM1L Antibody (C-term) (Catalog # M00556). Tested in WB application(s). This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-DNM1L Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00556)

Host

Rabbit

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

This DNM1L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DNM1L.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00556 is reactive to DNM1L in Human, Mouse, Rat

Applications

M00556 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

81.877kDa

Background of DRP1

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:8000

Validation Images & Assay Conditions

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All lanes : Anti-DNM1L Antibody (C-term) at 1:8000 dilution
Lane 1: PC-12 whole cell lysates
Lane 2: human skeletal muscle lysates
Lane 3: Hela whole cell lysates
Lane 4: NIH/3T3 whole cell lysates
Lane 5: LNCaP whole cell lysates
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size : 82 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Gene/Protein Information For DNM1L (Source: Uniprot.org, NCBI)

Alternative Names

DLP1; DRP1Dnm1p/Vps1p-like protein; DVLPEC 3.6.5.5; Dymple; DYMPLEDYNIV-11; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; dynamin-1-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-like protein; Dynamin-related protein 1; FLJ41912; HDYNIV; VPS1 DNM1L DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5 dynamin 1 like dynamin-1-like protein|Dnm1p/Vps1p-like protein|dynamin family member proline-rich carboxyl-terminal domain less|dynamin-like protein 4|dynamin-like protein IV|dynamin-related protein 1

For more info on DNM1L, check out the DNM1L Infographic

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In this infographic, you will see the following information for DNM1L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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