Transforming growth factor beta-1 proprotein (TGFB1)

Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors.

It plays an important role in bone remodeling as it's a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in dedicated osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401).