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- Table of Contents
MMP2 Antibodies
AND MMP2 ELISA kits, MMP2 Proteins
Many biological assays use antibodies to detect MMP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMP2 antibodies...
Designing a Western blot for MMP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MMP2 Western Blot GuideMMP2 Infographic by Boster Bio
All MMP2 Products
Product
Figures
Specificity
Applications
Price
Anti-MMP2 Antibody Picoband®
86 Citations
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00286-2
100 μg/vial
Cat # A00286-2
100 μg/vial
Human MMP-2 ELISA Kit PicoKine®
45 Citations
Human
ELISA
$499
Cat # EK0459
96 wells/kit, with removable strips.
Cat # EK0459
96 wells/kit, with removable strips.
Mouse MMP-2 ELISA Kit PicoKine®
25 Citations
Mouse
ELISA
$499
Cat # EK0460
96 wells/kit, with removable strips.
Cat # EK0460
96 wells/kit, with removable strips.
Anti-MMP2 Rabbit Monoclonal Antibody
48 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00286-1
100 μl
Cat # M00286-1
100 μl
Rat MMP-2 ELISA Kit PicoKine®
19 Citations
Rat
ELISA
$499
Cat # EK0639
96 wells/kit, with removable strips.
Cat # EK0639
96 wells/kit, with removable strips.
Rat MMP-2 PicoKine® Quick ELISA Kit
3 Citations
Rat
ELISA
$499
Cat # FEK0639
96 wells/kit, with removable strips.
Cat # FEK0639
96 wells/kit, with removable strips.
Mouse MMP-2 PicoKine® Quick ELISA Kit
1 Citations
Mouse
ELISA
$499
Cat # FEK0460
96 wells/kit, with removable strips.
Cat # FEK0460
96 wells/kit, with removable strips.
Human, Mouse, Rat
WB
$370
Cat # PA2212
100 μg/vial
Cat # PA2212
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00286-3
100 μl
Cat # M00286-3
100 μl
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07364-1
100 μg/vial
Cat # A07364-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00286-2
20μL, 40μL, 100μL, 200μL
Cat # M00286-2
20μL, 40μL, 100μL, 200μL
MMP2 Overview
Facts about 72 kDa type IV collagenase.
72 kDa type IV collagenase (MMP2)
Ubiquitinous metalloproteinase that's involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Also as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction.
Also cleaves KISS in a Gly-.
Gene Information
| Human | |
|---|---|
| Gene Name: | MMP2 |
| Uniprot: | P08253 |
| Entrez: | 4313 |
Family
| Belongs to: |
|---|
| peptidase M10A family |
Alternative Names
72 kDa gelatinase; CLG4; CLG4A72 kDa type IV collagenase; collagenase type IV-A; EC 3.4.24; EC 3.4.24.24; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase); matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP2; MMP-2; MMP-II; MONA; neutrophil gelatinase; TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
Molecular Weight
Mass (kDA):
73.882 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q12.2 |
| Sequence: | 16; NC_000016.10 (55478830..55506691) |
Tissue Specificity
Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Subcellular Localizations
[Isoform 1]: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; [Isoform 2]: Cytoplasm. Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Carcinoma
- Tissue Adhesions
- Tumor Angiogenesis
- Inflammation
- Fibrosis
- Malignant Paraganglionic Neoplasm
- Pathologic Neovascularization
Interacting Proteins
- APP
- COL5A1
- PCSK9
- SCUBE3
- TIMP2
Pathways
- Angiogenesis
- Cell Proliferation
- Cell Migration
- Secretion
- Pathogenesis
- Cell Adhesion
- Cell Growth
- Wound Healing
- Cell Cycle
- Localization
- Cell Motility
- Proteolysis
- Tissue Remodeling
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Nitration
- Reduction
- Oxidation
- Demethylation
Research Areas
- Angiogenesis
- Apoptosis
- Cancer
- Cell Biology
- Cellular Markers
- Extracellular Matrix
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP2
bosterbio.com/bosterbio-gene-info-cards/MMP2
References
PMID: 2162831 by Huhtala P., et al. Structure of the human type IV collagenase gene.
PMID: 1851724 by Collier I.E., et al. On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes.
196 Publications of Boster MMP2 Antibodies & ELISA Kits
- PubMed ID: PMID:31312367, Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angio...
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: PMID:28239811, The expression and significance of IL-6, IFN-γ, SM22α, and MMP-2 in rat model ...
- PubMed ID: PMID:25337249, Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value...
- PubMed ID: 10.7717/peerj.11664, Combination of ferulic acid, ligustrazine and tetrahydropalmatine inhibits invas...
- PubMed ID: 10.4314/tjpr.v16i11.13, Prophylactic effects of triptolide on colon cancer development in azoxymethane/d...
- PubMed ID: 10.4149/neo_2016_603, Silencing of ATPase family AAA domain-containing protein 2 inhibits migration an...
- PubMed ID: 10.3892/or_00000631, Hypoxia activates heparanase expression in an NF-κB dependent manner
- PubMed ID: 10.3892/or.2016.4757, SPOCK1 promotes the proliferation, migration and invasion of glioma cells throug...
- PubMed ID: 10.3892/or.2016.4707, NOB1 silencing inhibits the growth and metastasis of laryngeal cancer cells thro...
- PubMed ID: 10.3892/ol.2020.12020, Mechanism of transmembrane and coiled‑coil domain 1 in the regulation of proli...
- PubMed ID: 10.3892/ol.2017.5831, Marsdenia tenacissima extract suppresses tumor growth and angiogenesis in A20 mo...
- PubMed ID: 10.3892/mmr.2021.11938, Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats v...
- PubMed ID: 10.3892/mmr.2021.11833, MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migratio...
- PubMed ID: 10.3892/mmr.2019.10330, Calcium‑sensing receptor promotes high glucose‑induced myocardial fibrosis v...
- PubMed ID: 10.3892/mmr.2015.4449, Suppression of A549 cell proliferation and metastasis by calycosin via inhibitio...
- PubMed ID: 10.3892/ijo.2017.4148, Effects of baicalein on proliferation, apoptosis, migration and invasion of Ewin...
- PubMed ID: 10.3892/ijo.2016.3416, Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest a...
- PubMed ID: 10.3892/ijmm.2019.4237, Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression...
- PubMed ID: 10.3892/etm.2021.10390, FOXP3 facilitates the invasion and metastasis of non‑small cell lung cancer ce...
- PubMed ID: 10.3892/etm.2017.4458, KATP channels in high glucose-induced rat mesangial cell proliferation and relea...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page