Activity-regulated cytoskeleton-associated protein (Arc)

Master regulator of synaptic plasticity that self- assembles to virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, in which ARC mRNA can undergo activity-dependent translation (By similarity).

ARC capsids are endocytosed and have the ability to transfer ARC mRNA to the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the creation of long-term memory (PubMed:29264923, PubMed:24094104).