Many biological assays use antibodies to detect Complement C3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Complement C3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Complement C3 antibodies...
We validate the specificity of these antibodies to Complement C3 by testing them on tissues known to express C3 positively and negatively. Browse below to find the C3 antibody that suites your experiment. We have 59 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.
After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or resistant aggregates. .
Gene Information
Human
Gene Name:
C3
Uniprot:
P01024
Entrez:
718
Family
Belongs to:
No superfamily
Alternative Names
AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; complement C3; complement component 3; complement component C3; CPAMD1acylation-stimulating protein cleavage product
Molecular Weight
Mass (kDA): 187.148 kDA
Genomic Context
Human
Location:
19p13.3
Sequence:
19; NC_000019.10 (6677704..6720650, complement)
Tissue Specificity
Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
Subcellular Localizations
Secreted.
Diseases
Glomerulonephritis
Lupus Erythematosus, Systemic
Kidney Diseases
Inflammation
Proteinuria Of Undiagnosed Cause
Neoplasms
Nephritis
Malignant Neoplasms
Autoimmune Reaction
Infective Disorder
Hemolysis (disorder)
Arthritis
Rheumatoid Arthritis
Pain
Tissue Adhesions
Edema
Autoimmune Diseases
Glomerulonephritis, Membranoproliferative
Kidney Failure
Fracture
Interacting Proteins
CFB
CFH
Pathways
Complement Activation
Pathogenesis
Phagocytosis
Immune Response
Localization
Secretion
Opsonization
Transport
Inflammatory Response
Photosynthesis
Coagulation
Cell Proliferation
Excretion
Virulence
Hypersensitivity
Regeneration
Chemotaxis
Cell Death
Proteolysis
Cell Activation
PTMs
Cleavage
Phosphorylation
Ribosylation
Oxidation
Reduction
Glycosylation
Carboxylation
Methylation
Hydroxylation
Acylation
Geranylgeranylation
Decarboxylation
Prenylation
Acetylation
Dephosphorylation
Biotinylation
Nitration
Iodination
Amidation
Amination
Research Areas
Immunology
Innate Immunity
Neuronal Cell Markers
Neuroscience
For details, visit: bosterbio.com/bosterbio-gene-info-cards/C3
References
PMID: 2579379 by de Bruijn M.H.L., et al. Human complement component C3: cDNA coding sequence and derived primary structure.
PMID: 8376604 by Baldo A., et al. The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis.
7 Publications of Boster Complement C3 Antibodies & ELISA Kits
PubMed ID: 10.5713/ajas.19.0295, Effects of Astragalus membranaceus roots supplementation on growth performance, ...
PubMed ID: 10.1016/j.msec.2021.111932, Osteoclast differentiation and formation induced by titanium implantation throug...
PubMed ID: 10.1016/j.jtcvs.2018.09.017, Effect of preoperative inhaled budesonide on pulmonary injury after cardiopulmon...
PubMed ID: 10.1016/j.bbrc.2016.10.049, Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated t...