MED1 Antibodies

Mediator of RNA polymerase II transcription subunit 1 (MED1)

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator acts as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.

Mediator is recruited to promoters by direct interactions with regulatory proteins and functions as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Gene Information

Human
Gene Name:	MED1
Uniprot:	Q15648
Entrez:	5469

Family

Belongs to:
Mediator complex subunit 1 family

Alternative Names

Activator-recruited cofactor 205 kDa component; ARC205; CRSP1TRIP2; CRSP200p53 regulatory protein RB18A; DRIP230; DRIP230PPAR-binding protein; MBD4; MED1; mediator complex subunit 1DRIP205; mediator of RNA polymerase II transcription subunit 1; PBPPPARGBP; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPARBP; PPARBPMGC71488; PPARG binding protein; PPARGBP; RB18ATR-interacting protein 2; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting pro

Molecular Weight

Mass (kDA):
168.478 kDA

Genomic Context

Human
Location:	17q12
Sequence:	17; NC_000017.11 (39404285..39451281, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus. A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Carcinoma
• Microsatellite Instability
• Lung Neoplasms
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate
• Mutation, Out-of-frame
• Liver Carcinoma
• Inflammatory Response
• Cell Invasion

• Alzheimer's Disease
• Stomach Neoplasms
• Inflammation
• Endometrial Polyp
• Nervousness
• Cell Transformation, Neoplastic
• Leukemia

Interacting Proteins

• ESR1
• GATA1
• MED21
• MED7
• RARA

• RXRA
• THRA
• VDR

Pathways

• Mismatch Repair
• Dna Repair
• Methylation
• Cell Cycle
• Cell Proliferation
• Histone Acetylation
• Chromatin Remodeling
• Pathogenesis
• Cell Growth
• Mammary Gland Development
• Gland Development
• Keratinocyte Differentiation
• Inflammatory Response

• Localization
• Fatty Acid Oxidation
• Rna Interference
• Lactation
• Energy Homeostasis
• Transport
• Cell Death

PTMs

• Phosphorylation
• Acetylation
• Methylation
• Deamination

• Oxidation
• Cleavage
• Demethylation
• Reduction

• Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MED1

Boster Bio MED1 Cell-Based ELISA Kit

You've reached the right place if the ELISA kit for MED1 marker is what you're looking. This guide will provide information about the ELISA Kit for MED1 Cell-Based ELISA Kit and how it functions. We will also discuss how Boster scientists may use this product. This marker is suitable for many research purposes. However, before you use the MED1 cell-based ELISA kits to conduct your research you will need to understand the best uses for this marker.

MED1 Cell Based ELISA Kit

The Boster Bio MED1 Cell-Based Elisa Kit is a high-throughput and convenient tool for monitoring the expression of phosphorylation-regulated genes in cells. The kit allows researchers to measure the relative amount of PAK1 in cultured cells and can be used to screen for the effects of drugs and activators. It is easy to use and affordable for researchers.